GB1305820A - - Google Patents
Info
- Publication number
- GB1305820A GB1305820A GB1305820DA GB1305820A GB 1305820 A GB1305820 A GB 1305820A GB 1305820D A GB1305820D A GB 1305820DA GB 1305820 A GB1305820 A GB 1305820A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bis
- prepared
- compounds
- cyclizing
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Abstract
1305820 Bis-kynurenic acids IMPERIAL CHEMICAL INDUSTRIES Ltd 9 Aug 1971 [28 Sept 1970] 46048/70 Heading C2C [Also in Division A5] The invention comprises compounds of formula and their non-toxic pharmaceutically acceptable salts wherein the benzene rings A, B may be substituted by Me, or 1 or 2 halogen atoms and X (linked to positions 6, 6<SP>1</SP> or 8, 8<SP>1</SP>) is a direct link, -(CH 2 ) 2-3 -, -O(CH 2 ) 2-3 O-, -O-, -S-, -NH-, -N=N- or -CONH-; the compound where X is an 8,8<SP>1</SP>-direct link and rings A, B are unsubstituted, is excluded. In examples, these compounds are prepared by cyclizing the corresponding alkyl esters which are in turn prepared by cyclizing the corresponding bis-{iminophenyl) compounds, e.g. of formula [RO 2 CCH 2 C(CO 2 R) :NC 6 H 4 ] 2 X. Intermediates otherwise prepared are 2<SP>1</SP>,6<SP>1</SP>- dichloro - 1,2 - bis (4 - aminophenoxy)ethane and its N,N-diacetyl derivative.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4604870 | 1970-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1305820A true GB1305820A (en) | 1973-02-07 |
Family
ID=10439648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1305820D Expired GB1305820A (en) | 1970-09-28 | 1970-09-28 |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE2145423A1 (en) |
| FR (1) | FR2108023A1 (en) |
| GB (1) | GB1305820A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001030757A1 (en) * | 1999-10-28 | 2001-05-03 | Microcide Pharmaceuticals, Inc. | Drug discharge pump inhibitors |
| US7056917B2 (en) | 2001-04-26 | 2006-06-06 | Daiichi Pharmaceutical Co., Ltd. | Drug efflux pump inhibitor |
| WO2020113554A1 (en) * | 2018-12-07 | 2020-06-11 | 东莞市东阳光农药研发有限公司 | Quinoline derivative and preparation method and application thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3865831A (en) * | 1972-06-09 | 1975-02-11 | Upjohn Co | 1,1{40 ,4,4{40 -tetrahydro-4,4{40 -dioxo(6,6{40 biquinoline)-2,2{40 -dicarboxylates |
| US4156726A (en) * | 1974-12-07 | 1979-05-29 | Fisons Limited | 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds |
| DE2856908A1 (en) * | 1978-12-28 | 1980-07-17 | Schering Ag | NEW CHINOLON CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS |
-
1970
- 1970-09-28 GB GB1305820D patent/GB1305820A/en not_active Expired
-
1971
- 1971-09-10 DE DE19712145423 patent/DE2145423A1/en active Pending
- 1971-09-27 FR FR7134620A patent/FR2108023A1/fr not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001030757A1 (en) * | 1999-10-28 | 2001-05-03 | Microcide Pharmaceuticals, Inc. | Drug discharge pump inhibitors |
| EP1652839A2 (en) * | 1999-10-28 | 2006-05-03 | Daiichi Pharmaceutical Co., Ltd. | Drug efflux pump inhibitor |
| EP1652839A3 (en) * | 1999-10-28 | 2006-07-05 | Daiichi Pharmaceutical Co., Ltd. | Drug efflux pump inhibitor |
| US7056917B2 (en) | 2001-04-26 | 2006-06-06 | Daiichi Pharmaceutical Co., Ltd. | Drug efflux pump inhibitor |
| WO2020113554A1 (en) * | 2018-12-07 | 2020-06-11 | 东莞市东阳光农药研发有限公司 | Quinoline derivative and preparation method and application thereof |
| CN111566088A (en) * | 2018-12-07 | 2020-08-21 | 东莞市东阳光农药研发有限公司 | Quinoline derivative and preparation method and application thereof |
| CN111566088B (en) * | 2018-12-07 | 2022-07-08 | 东莞市东阳光农药研发有限公司 | Quinoline derivative and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2108023A1 (en) | 1972-05-12 |
| DE2145423A1 (en) | 1972-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |