GB1305548A - - Google Patents

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Publication number
GB1305548A
GB1305548A GB1305548DA GB1305548A GB 1305548 A GB1305548 A GB 1305548A GB 1305548D A GB1305548D A GB 1305548DA GB 1305548 A GB1305548 A GB 1305548A
Authority
GB
United Kingdom
Prior art keywords
reaction
prepared
formula
amine
benzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1305548A publication Critical patent/GB1305548A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Abstract

1305548 Thioureas SMITH KLINE & FRENCH LABORATORIES Ltd 26 Oct 1970 [29 Oct 1969] 13449/72 Divided out of 1305546 Heading C2C Novel compounds of formula wherein X is H, amino, C 1-4 alkyl or C 1-4 alkylthio, n is 2 to 5 and R is H, C 1-4 alkyl aryl aralkyl or benzoyl are prepared by reaction of an amine of Formula II with an isocyanate RNCS or with CS 2 then an amine RNH 2 and compound where R is benzoyl may be hydrolysed to compounds where R is H. Amines of Formula II above are prepared (a) by reaction of 1-bromo-7-phthalimidoheptan-2-one and formamide followed by hydrolysis and chromatography or (b) by reduction of the nitrile which may be obtained by reaction of sodium cyanide and the appropriate halide. N - [3 - (4(5) - imidazolyl)propyl] - dithiocarbamic acid and its methyl ester are prepared from the amine by reaction with CS 2 and methylation.
GB1305548D 1969-10-29 1969-10-29 Expired GB1305548A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1344972 1969-10-29

Publications (1)

Publication Number Publication Date
GB1305548A true GB1305548A (en) 1973-02-07

Family

ID=10023197

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1305548D Expired GB1305548A (en) 1969-10-29 1969-10-29

Country Status (1)

Country Link
GB (1) GB1305548A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
US4165377A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidino imidazoles and thiazoles
US4247705A (en) * 1979-02-06 1981-01-27 A. H. Robins Company, Inc. 4-Substituted 2-iminoimidazolidine compounds
FR2686084A1 (en) * 1992-01-10 1993-07-16 Bioprojet Soc Civ NEW IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS
WO1995006037A1 (en) * 1993-08-27 1995-03-02 Vrije Universiteit New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor
NL9302045A (en) * 1993-08-27 1995-03-16 Vrije Universiteit New imidazole derivative with agonistic or antagonistic activity on the histamine H3 receptor
USRE37303E1 (en) * 1992-01-10 2001-07-31 Institut National Del La Sante Et De La Recherche Medicale Imidazole compounds and their therapeutic applications
EP1311477A1 (en) * 2000-08-21 2003-05-21 Pacific Corporation Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
US4165377A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidino imidazoles and thiazoles
US4234735A (en) 1977-04-20 1980-11-18 Imperial Chemical Industries Limited Guanidino imidazoles and thiazoles
US4262126A (en) 1977-04-20 1981-04-14 Imperial Chemical Industries Limited Guanidine derivatives of imidazoles and thiazoles
US4247705A (en) * 1979-02-06 1981-01-27 A. H. Robins Company, Inc. 4-Substituted 2-iminoimidazolidine compounds
WO1993014070A2 (en) * 1992-01-10 1993-07-22 Institut National De La Sante Et De La Recherche Medicale Novel imidazole derivatives, their preparation and therapeutic applications
FR2686084A1 (en) * 1992-01-10 1993-07-16 Bioprojet Soc Civ NEW IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS
WO1993014070A3 (en) * 1992-01-10 1993-08-19 Inst Nat Sante Rech Med Novel imidazole derivatives, their preparation and therapeutic applications
US5559113A (en) * 1992-01-10 1996-09-24 Institut National De La Sante Et De La Recherche Medicale Imidazole compounds and their therapeutic applications
US5708171A (en) * 1992-01-10 1998-01-13 Institut National De La Sante Et De La Recherche Medicale Imidazole derivatives for pharmaceutical use
USRE37303E1 (en) * 1992-01-10 2001-07-31 Institut National Del La Sante Et De La Recherche Medicale Imidazole compounds and their therapeutic applications
WO1995006037A1 (en) * 1993-08-27 1995-03-02 Vrije Universiteit New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor
NL9302045A (en) * 1993-08-27 1995-03-16 Vrije Universiteit New imidazole derivative with agonistic or antagonistic activity on the histamine H3 receptor
EP1311477A1 (en) * 2000-08-21 2003-05-21 Pacific Corporation Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same
EP1311477A4 (en) * 2000-08-21 2005-01-12 Pacific Corp Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee