GB1330704A - Purine derivatives - Google Patents
Purine derivativesInfo
- Publication number
- GB1330704A GB1330704A GB4660170A GB4660170A GB1330704A GB 1330704 A GB1330704 A GB 1330704A GB 4660170 A GB4660170 A GB 4660170A GB 4660170 A GB4660170 A GB 4660170A GB 1330704 A GB1330704 A GB 1330704A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- alkoxy
- aryl
- alkyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1330704 Purine derivatives FUJISAWA PHARMACEUTICAL CO Ltd 30 Sept 1970 [25 Oct 1969 6 Dec 1969] 46601/70 Addition to 1284581 Heading C2C Novel compounds I: in which A is N or N -# O; R 1 is H, halo, OH, SH, 1-8 C alkoxy, aryl-(1-8 C alkoxy), 1-8 C alkylthio, NH 2 , mono- or di-(1-8 C alkyl)- amino, aryl-(1-8 C alkyl)-amino, acylamino, or NHOH; R 2 and R 3 are H, halo, OH, SH, NH 2 , 1-8 C alkyl, aryl, 1-8 C alkoxy, aryl-(1-8 C alkoxy), or 1-8 C alkylthio; R 4 is H or acyl and R 5 is OH, alkoxy, NH 2 or mono- or di-(1-8 C alkyl)-amino and their salts are prepared by cyclization of appropriately substituted pyrimidine derivatives; by reaction of the appropriate 9-unsubstituted purine with a lactone [B]. by conventional modification of the group COR 5 or by modification of any substituents on the purine ring in an appropriate starting material to give products I. Intermediates isolated are 4 - (5,6 - diamino- 4 - pyrimidinylamino) - 2 - hydroxy - butyric acid, prepared by reacting 6-amino-5-nitro-4-chloropyrimidine with 4-amino-2-hydroxy butyric acid to give 4-(6-amino-5-nitro-4-pyrimidinylamino) - 2 - hydroxybutyric acid and reducing this; and 4-(5-formamido-6-amino-4-pyrimidinyl amino)-2-hydroxy-butyric acid, prepared by reduction of the corresponding 5-nitro compound in the presence of formic acid. Pharmaceutical compositions having hypocholesterolemic activity comprise a compound I together with a suitable excipient in forms suitable for enteral or parenteral application.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8541669 | 1969-10-25 | ||
JP9801369A JPS4820559B1 (en) | 1969-12-06 | 1969-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1330704A true GB1330704A (en) | 1973-09-19 |
Family
ID=26426430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4660170A Expired GB1330704A (en) | 1969-10-25 | 1970-09-30 | Purine derivatives |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE756914A (en) |
DE (1) | DE2047973A1 (en) |
FR (1) | FR2070162B1 (en) |
GB (1) | GB1330704A (en) |
NL (1) | NL7014367A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005009334A3 (en) * | 2003-04-09 | 2005-09-29 | Gen Atomics | Reversible inhibitors of s-adenosyl-l-homocysteine hydrolase and uses thereof |
WO2006044573A3 (en) * | 2004-10-13 | 2006-06-15 | Gen Atomics | Reversible inhibitors of s-adenosyl-l-homocysteine hydrolase and uses thereof |
EP2230239A1 (en) * | 2007-12-10 | 2010-09-22 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | A method for preparing 4-ý9-(6-aminopurine)¨-2-(s)-hydroxyl-butyric acid methyl ester |
US7868011B2 (en) | 2003-04-09 | 2011-01-11 | General Atomics | Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus |
-
0
- BE BE756914D patent/BE756914A/en unknown
-
1970
- 1970-09-29 FR FR7035209A patent/FR2070162B1/fr not_active Expired
- 1970-09-30 DE DE19702047973 patent/DE2047973A1/en active Pending
- 1970-09-30 GB GB4660170A patent/GB1330704A/en not_active Expired
- 1970-09-30 NL NL7014367A patent/NL7014367A/xx unknown
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8168643B2 (en) | 2003-04-09 | 2012-05-01 | General Atomics | Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof |
US7196093B2 (en) | 2003-04-09 | 2007-03-27 | General Atomics | Reversible inhibitors of SAH hydrolase and uses thereof |
US7517887B2 (en) * | 2003-04-09 | 2009-04-14 | General Atomics | Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof |
WO2005009334A3 (en) * | 2003-04-09 | 2005-09-29 | Gen Atomics | Reversible inhibitors of s-adenosyl-l-homocysteine hydrolase and uses thereof |
US7868011B2 (en) | 2003-04-09 | 2011-01-11 | General Atomics | Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus |
WO2006044573A3 (en) * | 2004-10-13 | 2006-06-15 | Gen Atomics | Reversible inhibitors of s-adenosyl-l-homocysteine hydrolase and uses thereof |
EP1799682A2 (en) * | 2004-10-13 | 2007-06-27 | General Atomics | Reversible inhibitors of s-adenosyl-l-homocysteine hydrolase and uses thereof |
EP1799682A4 (en) * | 2004-10-13 | 2009-11-04 | Gen Atomics | Reversible inhibitors of s-adenosyl-l-homocysteine hydrolase and uses thereof |
EP2230239A1 (en) * | 2007-12-10 | 2010-09-22 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | A method for preparing 4-ý9-(6-aminopurine)¨-2-(s)-hydroxyl-butyric acid methyl ester |
JP2011506349A (en) * | 2007-12-10 | 2011-03-03 | 中国科学院上海薬物研究所 | Preparation of 4- [9- (6-aminopurine group)]-2 (S) -hydroxybutyric acid methyl ester |
EP2230239A4 (en) * | 2007-12-10 | 2011-10-19 | Shanghai Inst Materia Medica | A method for preparing 4-ý9-(6-aminopurine)¨-2-(s)-hydroxyl-butyric acid methyl ester |
CN101456860B (en) * | 2007-12-10 | 2011-02-16 | 中国科学院上海药物研究所 | Process for preparing 4-[9-(6-aminopurine)]-2(S)-hydroxybutyrate methyl ester |
US8247549B2 (en) | 2007-12-10 | 2012-08-21 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Method for preparing 4-(6-amino-purin-9-YL)-2(S)-hydroxy-butyric acid methyl ester |
Also Published As
Publication number | Publication date |
---|---|
NL7014367A (en) | 1971-04-27 |
BE756914A (en) | 1971-03-30 |
DE2047973A1 (en) | 1971-05-06 |
FR2070162B1 (en) | 1974-02-01 |
FR2070162A1 (en) | 1971-09-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |