GB1298508A - Novel tetracyclines - Google Patents
Novel tetracyclinesInfo
- Publication number
- GB1298508A GB1298508A GB27595/70A GB2759570A GB1298508A GB 1298508 A GB1298508 A GB 1298508A GB 27595/70 A GB27595/70 A GB 27595/70A GB 2759570 A GB2759570 A GB 2759570A GB 1298508 A GB1298508 A GB 1298508A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methoxy
- chloro
- octahydro
- dioxo
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004098 Tetracycline Substances 0.000 title abstract 3
- 235000019364 tetracycline Nutrition 0.000 title abstract 3
- 150000003522 tetracyclines Chemical class 0.000 title abstract 3
- 229940040944 tetracyclines Drugs 0.000 title abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 2
- NPOMGSRFSYKJOE-UHFFFAOYSA-N 2-(8'-chloro-5'-methoxyspiro[1,3-dioxolane-2,4'-2,3-dihydro-1H-naphthalene]-2'-yl)ethanol Chemical compound ClC=1C=CC(=C2C3(CC(CC12)CCO)OCCO3)OC NPOMGSRFSYKJOE-UHFFFAOYSA-N 0.000 abstract 1
- RWRINJLHMWREDS-UHFFFAOYSA-N 3-(8'-chloro-5'-methoxyspiro[1,3-dioxolane-2,4'-2,3-dihydro-1H-naphthalene]-2'-yl)propanenitrile Chemical compound ClC=1C=CC(=C2C3(CC(CC12)CCC#N)OCCO3)OC RWRINJLHMWREDS-UHFFFAOYSA-N 0.000 abstract 1
- CATPWBAUJLSLRQ-UHFFFAOYSA-N 3-(8-chloro-5-methoxy-4-oxo-2,3-dihydro-1H-naphthalen-2-yl)propanal Chemical compound ClC=1C=CC(=C2C(CC(CC12)CCC=O)=O)OC CATPWBAUJLSLRQ-UHFFFAOYSA-N 0.000 abstract 1
- IHAKPEXEBJCICW-UHFFFAOYSA-N 4-[2-(8-chloro-5-methoxy-4-oxo-3H-naphthalen-2-yl)ethylidene]-2-phenyl-1,3-oxazol-5-one Chemical compound ClC=1C=CC(=C2C(CC(=CC12)CC=C1N=C(OC1=O)C1=CC=CC=C1)=O)OC IHAKPEXEBJCICW-UHFFFAOYSA-N 0.000 abstract 1
- MLVKPIFZOXYSDW-UHFFFAOYSA-N C(C)(C)(C)NC(=O)C=1C(C2C(=C3C(C4=C(C=CC(=C4CC3CC2C(C1O)NC(C1=CC=CC=C1)=O)Cl)OC)=O)O)=O Chemical compound C(C)(C)(C)NC(=O)C=1C(C2C(=C3C(C4=C(C=CC(=C4CC3CC2C(C1O)NC(C1=CC=CC=C1)=O)Cl)OC)=O)O)=O MLVKPIFZOXYSDW-UHFFFAOYSA-N 0.000 abstract 1
- OGMUCPOTKUFUDG-UHFFFAOYSA-N Cl.C(C)(C)(C)NC(=O)C=1C(C2(C(=C3C(C4=C(C=CC(=C4CC3CC2C(C1O)N(C)C)Cl)OC)=O)O)O)=O Chemical compound Cl.C(C)(C)(C)NC(=O)C=1C(C2(C(=C3C(C4=C(C=CC(=C4CC3CC2C(C1O)N(C)C)Cl)OC)=O)O)O)=O OGMUCPOTKUFUDG-UHFFFAOYSA-N 0.000 abstract 1
- ZYWHNCGZPLPIHZ-UHFFFAOYSA-N Cl.C(C)(C)(C)NC(=O)C=1C(C2(C(=C3C(C4=C(C=CC(=C4CC3CC2C(C1O)N)Cl)OC)=O)O)O)=O Chemical compound Cl.C(C)(C)(C)NC(=O)C=1C(C2(C(=C3C(C4=C(C=CC(=C4CC3CC2C(C1O)N)Cl)OC)=O)O)O)=O ZYWHNCGZPLPIHZ-UHFFFAOYSA-N 0.000 abstract 1
- SIFSPSJBJAHKOF-UHFFFAOYSA-N ClC=1C=CC(=C2C(CC(CC12)C(=O)OC)=O)OC Chemical compound ClC=1C=CC(=C2C(CC(CC12)C(=O)OC)=O)OC SIFSPSJBJAHKOF-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000000640 hydroxylating effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- AXTWDTLHPKZYFA-UHFFFAOYSA-N methyl 5-amino-3,5-dioxopentanoate Chemical compound COC(=O)CC(=O)CC(N)=O AXTWDTLHPKZYFA-UHFFFAOYSA-N 0.000 abstract 1
- XMFVFACGIMCUNV-UHFFFAOYSA-N methyl 8'-chloro-5'-methoxyspiro[1,3-dioxolane-2,4'-2,3-dihydro-1H-naphthalene]-2'-carboxylate Chemical compound ClC=1C=CC(=C2C3(CC(CC12)C(=O)OC)OCCO3)OC XMFVFACGIMCUNV-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/42—One oxygen atom attached in position 5
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83268169A | 1969-06-12 | 1969-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1298508A true GB1298508A (en) | 1972-12-06 |
Family
ID=25262345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27595/70A Expired GB1298508A (en) | 1969-06-12 | 1970-06-08 | Novel tetracyclines |
Country Status (11)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7825105B2 (en) | 2002-07-12 | 2010-11-02 | Paratek Pharmaceuticals, Inc. | 3, 10, and 12a substituted tetracycline compounds |
-
1970
- 1970-05-20 AU AU15320/70A patent/AU1532070A/en not_active Expired
- 1970-06-08 GB GB27595/70A patent/GB1298508A/en not_active Expired
- 1970-06-10 AT AT523170A patent/AT307392B/de not_active IP Right Cessation
- 1970-06-11 ES ES380657A patent/ES380657A1/es not_active Expired
- 1970-06-11 DE DE19702028705 patent/DE2028705A1/de active Pending
- 1970-06-11 CA CA085240A patent/CA926389A/en not_active Expired
- 1970-06-11 FR FR7021532A patent/FR2052959A1/fr not_active Withdrawn
- 1970-06-11 LU LU61109D patent/LU61109A1/xx unknown
- 1970-06-11 NL NL7008573A patent/NL7008573A/xx unknown
- 1970-06-11 BE BE751830D patent/BE751830A/xx unknown
- 1970-06-12 ZA ZA704006A patent/ZA704006B/xx unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7825105B2 (en) | 2002-07-12 | 2010-11-02 | Paratek Pharmaceuticals, Inc. | 3, 10, and 12a substituted tetracycline compounds |
| KR101089429B1 (ko) * | 2002-07-12 | 2011-12-07 | 파라테크 파마슈티컬스, 인크. | 3, 10, 및 12ａ 치환된 테트라시클린 화합물 |
| US8481513B2 (en) | 2002-07-12 | 2013-07-09 | Paratek Pharmaceuticals, Inc. | 3, 10, and 12a substituted tetracycline compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| AT307392B (de) | 1973-05-25 |
| NL7008573A (enrdf_load_stackoverflow) | 1970-12-15 |
| CA926389A (en) | 1973-05-15 |
| DE2028705A1 (enrdf_load_stackoverflow) | 1972-02-17 |
| AU1532070A (en) | 1971-12-09 |
| ZA704006B (en) | 1971-01-27 |
| FR2052959A1 (enrdf_load_stackoverflow) | 1971-04-16 |
| BE751830A (fr) | 1970-11-16 |
| LU61109A1 (enrdf_load_stackoverflow) | 1970-08-12 |
| ES380657A1 (es) | 1972-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |