GB1281902A - 3,4-diazapregnanes - Google Patents
3,4-diazapregnanesInfo
- Publication number
- GB1281902A GB1281902A GB4855269A GB4855269A GB1281902A GB 1281902 A GB1281902 A GB 1281902A GB 4855269 A GB4855269 A GB 4855269A GB 4855269 A GB4855269 A GB 4855269A GB 1281902 A GB1281902 A GB 1281902A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- haloaryl
- aryl
- term
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
1281902 A-heterosteroids E R SQUIBB & SONS Inc 2 Oct 1969 48552/69 Heading C2C The invention comprises compounds of Formulµ II and III wherein R is H, alkyl, aryl, arylalkyl, haloalkyl, haloaryl or haloaryl-alkyl or trifluoromethylaryl (the term "alkyl" signifying C 1-6 alkyl and the term "aryl" being inclusive of alkaryl) ; and their preparation by converting 5-hydroxy-3-oxa-A- nor-5#-pregnane-2,20-dione to the 20-ethylene ketal thereof, reacting the latter with RNHNH 2 followed by hydrolysis of the ketal group to give II which may then be reduced with LiAlH 4 to give III. The inventive compounds are said to possess antiandrogenic activity and may be made up with carriers into pharmaceutical compositions for oral administration.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4855269A GB1281902A (en) | 1969-10-02 | 1969-10-02 | 3,4-diazapregnanes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4855269A GB1281902A (en) | 1969-10-02 | 1969-10-02 | 3,4-diazapregnanes |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1281902A true GB1281902A (en) | 1972-07-19 |
Family
ID=10449014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4855269A Expired GB1281902A (en) | 1969-10-02 | 1969-10-02 | 3,4-diazapregnanes |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1281902A (en) |
-
1969
- 1969-10-02 GB GB4855269A patent/GB1281902A/en not_active Expired
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |