GB1269657A - Prostaglandin analogues, their preparation and pharmaceutical compositions containing them - Google Patents

Prostaglandin analogues, their preparation and pharmaceutical compositions containing them

Info

Publication number
GB1269657A
GB1269657A GB38073/69A GB3807369A GB1269657A GB 1269657 A GB1269657 A GB 1269657A GB 38073/69 A GB38073/69 A GB 38073/69A GB 3807369 A GB3807369 A GB 3807369A GB 1269657 A GB1269657 A GB 1269657A
Authority
GB
United Kingdom
Prior art keywords
oxa
endo
hex
oxobicyclo
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB38073/69A
Other languages
English (en)
Inventor
Norman Allan Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE754114D priority Critical patent/BE754114A/xx
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to GB38073/69A priority patent/GB1269657A/en
Priority to ZA704099A priority patent/ZA704099B/xx
Priority to NL7010617A priority patent/NL7010617A/xx
Priority to DE19702036471 priority patent/DE2036471A1/de
Priority to HUUO67A priority patent/HU162688B/hu
Priority to HUUO66A priority patent/HU162687B/hu
Priority to SE7010366A priority patent/SE383513B/xx
Priority to FR7027783A priority patent/FR2059574B1/fr
Priority to JP45065821A priority patent/JPS5028950B1/ja
Priority to CH1147370A priority patent/CH571486A5/xx
Priority to CH303273A priority patent/CH571487A5/xx
Publication of GB1269657A publication Critical patent/GB1269657A/en
Priority to JP47056175A priority patent/JPS503311B1/ja
Priority to US461583A priority patent/US3920724A/en
Priority to US461603A priority patent/US3922298A/en
Priority to US461508A priority patent/US3923861A/en
Priority to US05/461,497 priority patent/US3944593A/en
Priority to US461496A priority patent/US3923863A/en
Priority to US461543A priority patent/US3920723A/en
Priority to US461597A priority patent/US3923865A/en
Priority to US461498A priority patent/US3923864A/en
Priority to US461489A priority patent/US3923862A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/27—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB38073/69A 1969-07-29 1969-07-29 Prostaglandin analogues, their preparation and pharmaceutical compositions containing them Expired GB1269657A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
BE754114D BE754114A (fr) 1969-07-29 Nouveaux composes de la classe des prostaglandines et leur procede de preparation
GB38073/69A GB1269657A (en) 1969-07-29 1969-07-29 Prostaglandin analogues, their preparation and pharmaceutical compositions containing them
ZA704099A ZA704099B (en) 1969-07-29 1970-06-16 Prostaglandin analogs and the process therefor
NL7010617A NL7010617A (enrdf_load_html_response) 1969-07-29 1970-07-17
DE19702036471 DE2036471A1 (enrdf_load_html_response) 1969-07-29 1970-07-23
HUUO67A HU162688B (enrdf_load_html_response) 1969-07-29 1970-07-24
HUUO66A HU162687B (enrdf_load_html_response) 1969-07-29 1970-07-24
SE7010366A SE383513B (sv) 1969-07-29 1970-07-28 Forfarande for framstellning av i stellningarna 7 och 15 ev. substituerade prostaglandinestrar och fria syror av typ 3-oxa-pga med blodtryckssenkande egenskaper.
FR7027783A FR2059574B1 (enrdf_load_html_response) 1969-07-29 1970-07-28
CH303273A CH571487A5 (enrdf_load_html_response) 1969-07-29 1970-07-29
CH1147370A CH571486A5 (enrdf_load_html_response) 1969-07-29 1970-07-29
JP45065821A JPS5028950B1 (enrdf_load_html_response) 1969-07-29 1970-07-29
JP47056175A JPS503311B1 (enrdf_load_html_response) 1969-07-29 1972-06-07
US461489A US3923862A (en) 1969-07-29 1974-04-17 4-Oxa prostaglandin {62 -type compounds
US461508A US3923861A (en) 1969-07-29 1974-04-17 3-Oxa prostaglandin F{331 -type compounds
US461603A US3922298A (en) 1969-07-29 1974-04-17 3-Oxa prostaglandin B-type compounds
US461583A US3920724A (en) 1969-07-29 1974-04-17 4-oxa prostaglandin f ' -type compounds
US05/461,497 US3944593A (en) 1969-07-29 1974-04-17 3-Oxa prostaglandin E-type compounds
US461496A US3923863A (en) 1969-07-29 1974-04-17 4-Oxa prostaglandin A-type compounds
US461543A US3920723A (en) 1969-07-29 1974-04-17 4-oxaprostaglandin e-type compounds
US461597A US3923865A (en) 1969-07-29 1974-04-17 4-Oxa prostaglandin F{62 -type compounds
US461498A US3923864A (en) 1969-07-29 1974-04-17 3-Oxa prostaglandin A-type compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB38073/69A GB1269657A (en) 1969-07-29 1969-07-29 Prostaglandin analogues, their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
GB1269657A true GB1269657A (en) 1972-04-06

Family

ID=10400988

Family Applications (1)

Application Number Title Priority Date Filing Date
GB38073/69A Expired GB1269657A (en) 1969-07-29 1969-07-29 Prostaglandin analogues, their preparation and pharmaceutical compositions containing them

Country Status (10)

Country Link
JP (2) JPS5028950B1 (enrdf_load_html_response)
BE (1) BE754114A (enrdf_load_html_response)
CH (2) CH571486A5 (enrdf_load_html_response)
DE (1) DE2036471A1 (enrdf_load_html_response)
FR (1) FR2059574B1 (enrdf_load_html_response)
GB (1) GB1269657A (enrdf_load_html_response)
HU (2) HU162687B (enrdf_load_html_response)
NL (1) NL7010617A (enrdf_load_html_response)
SE (1) SE383513B (enrdf_load_html_response)
ZA (1) ZA704099B (enrdf_load_html_response)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181725A (en) * 1977-05-02 1980-01-01 The Regents Of The University Of Michigan Method for alleviating psoriasis
US5891910A (en) * 1987-07-17 1999-04-06 Schering Aktiengesellschaft 9-halogen-(Z) prostaglandin derivatives, process for their production and their use as pharmaceutical agents
US6225347B1 (en) 1987-07-17 2001-05-01 Schering Aktiengesellschaft 9-halogen-(Z)-prostaglandin derivatives, process for their production and their use as pharmaceutical agents

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944593A (en) * 1969-07-29 1976-03-16 The Upjohn Company 3-Oxa prostaglandin E-type compounds
US3923863A (en) * 1969-07-29 1975-12-02 Upjohn Co 4-Oxa prostaglandin A-type compounds
US3920723A (en) * 1969-07-29 1975-11-18 Upjohn Co 4-oxaprostaglandin e-type compounds
US3923861A (en) * 1969-07-29 1975-12-02 Upjohn Co 3-Oxa prostaglandin F{331 -type compounds
US3923865A (en) * 1969-07-29 1975-12-02 Upjohn Co 4-Oxa prostaglandin F{62 -type compounds
US3922298A (en) * 1969-07-29 1975-11-25 Upjohn Co 3-Oxa prostaglandin B-type compounds
US3920724A (en) * 1969-07-29 1975-11-18 Upjohn Co 4-oxa prostaglandin f ' -type compounds
US3923864A (en) * 1969-07-29 1975-12-02 Upjohn Co 3-Oxa prostaglandin A-type compounds
US3923862A (en) * 1969-07-29 1975-12-02 Upjohn Co 4-Oxa prostaglandin {62 -type compounds
US3936487A (en) * 1970-06-17 1976-02-03 The Upjohn Company 3-Oxa prostaglandin Fα-type compounds
DE2258668C3 (de) * 1971-12-03 1981-08-06 Syntex Corp., Panama-City Neue Prostaglandine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US4001296A (en) * 1973-05-21 1977-01-04 The Upjohn Company 5-Oxa prostaglandin E1 analogs
US3931279A (en) * 1973-05-21 1976-01-06 The Upjohn Company 5-Oxa prostaglandin F2.sub.α analogs
US3980692A (en) * 1973-05-21 1976-09-14 The Upjohn Company 5-Oxa-17,18-dehydroprostaglandin-E1 -type analogs
US3981902A (en) * 1973-05-21 1976-09-21 The Upjohn Company 5-Oxa-17,18-dehydroprostaglandin-F1.sub.α -type analogs
JPS5215047U (enrdf_load_html_response) * 1975-07-22 1977-02-02
JPS5235356A (en) * 1975-09-13 1977-03-17 Toyo Seisakusho:Kk Manufacturing method of heat recovery device using heat pipe
JPS5491311U (enrdf_load_html_response) * 1977-12-10 1979-06-28
JPS60238552A (ja) * 1984-05-09 1985-11-27 日本軽金属株式会社 カ−テンウオ−ル
JPS6443107U (enrdf_load_html_response) * 1987-09-08 1989-03-15
JPH0380812U (enrdf_load_html_response) * 1989-08-16 1991-08-19

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181725A (en) * 1977-05-02 1980-01-01 The Regents Of The University Of Michigan Method for alleviating psoriasis
US5891910A (en) * 1987-07-17 1999-04-06 Schering Aktiengesellschaft 9-halogen-(Z) prostaglandin derivatives, process for their production and their use as pharmaceutical agents
US6225347B1 (en) 1987-07-17 2001-05-01 Schering Aktiengesellschaft 9-halogen-(Z)-prostaglandin derivatives, process for their production and their use as pharmaceutical agents

Also Published As

Publication number Publication date
JPS5028950B1 (enrdf_load_html_response) 1975-09-19
FR2059574B1 (enrdf_load_html_response) 1974-03-22
CH571486A5 (enrdf_load_html_response) 1976-01-15
FR2059574A1 (enrdf_load_html_response) 1971-06-04
CH571487A5 (enrdf_load_html_response) 1976-01-15
NL7010617A (enrdf_load_html_response) 1971-02-02
BE754114A (fr) 1971-01-29
HU162688B (enrdf_load_html_response) 1973-03-28
HU162687B (enrdf_load_html_response) 1973-03-28
JPS503311B1 (enrdf_load_html_response) 1975-02-03
SE383513B (sv) 1976-03-15
ZA704099B (en) 1971-03-31
DE2036471A1 (enrdf_load_html_response) 1971-02-11

Similar Documents

Publication Publication Date Title
GB1269657A (en) Prostaglandin analogues, their preparation and pharmaceutical compositions containing them
US4163107A (en) ω-Aryl-cis-13-PGF compounds
US4083865A (en) Inter-oxa-13,14-dihydro-PGD1 compounds
US4097508A (en) Cis-4,5-didehydro-13,14 dihydro-9, dioxy PGF compounds
GB1282661A (en) Prostaglandins and the manufacture thereof
US4124621A (en) Cis-4,5-didehydro-12,13(e)-didehydro-13,14-dihydro-9-deoxy-PGD1 compounds
GB1484591A (en) Prostaglandin compositions
GB1497218A (en) Thiaprostaglandins
GB1496491A (en) Dihydroergopeptine derivatives
GB1396206A (en) Prostaglandins and the preparation thereof
GB1433973A (en) Prostaglandin intermediates
GB1410853A (en) Pharmaceutically useful prostaglandin derivatives
US4001286A (en) Phenyl-substituted prostaglandin-β-type anologs
GB1399089A (en) Carboxylic acids and derivatives thereof
GB1493557A (en) Fluoro-prostaglandins and process for their preparation
GB1456511A (en) P-biphenylyl esters of 15-substituted-16,17,18,19,20-pentanor prostaglandins
GB1445628A (en) Prostaglandin derivatives
GB1434620A (en) Prostaglandins and the preparation thereof
ES427614A1 (es) Un procedimiento para producir nuevos derivados de prosta- glandinas.
GB1420338A (en) 8,12-di-isoprostanoic acid derivatives
GB1397434A (en) Evomonoside derivatives
ES418575A1 (es) Un procedimiento para preparar un compuesto seleccionado delgrupo de antimeros y mezclas recenicas de los mismos.
GB1219387A (en) Bicyclo[2.2.2]oct-2-ene-amino acid compounds
GB1269656A (en) Improvements in or relating to prostaglandin derivatives and the manufacture thereof
GB1425808A (en) Pharmaceutically useful prostanoic acid derivatives