GB1268465A - Substituted salicylic acid compounds - Google Patents
Substituted salicylic acid compoundsInfo
- Publication number
- GB1268465A GB1268465A GB2966870A GB2966870A GB1268465A GB 1268465 A GB1268465 A GB 1268465A GB 2966870 A GB2966870 A GB 2966870A GB 2966870 A GB2966870 A GB 2966870A GB 1268465 A GB1268465 A GB 1268465A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkoxy
- conh
- alkyl
- compounds
- alkoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical class OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- -1 polyhydroxyalkoxy Chemical group 0.000 abstract 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 238000009833 condensation Methods 0.000 abstract 2
- 230000005494 condensation Effects 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 abstract 1
- INECGQVKAYUORO-UHFFFAOYSA-N 4-fluoro-N-[4-hydroxy-2-(trifluoromethyl)phenyl]benzamide Chemical compound FC1=CC=C(C(=O)NC2=C(C=C(C=C2)O)C(F)(F)F)C=C1 INECGQVKAYUORO-UHFFFAOYSA-N 0.000 abstract 1
- RBEXRIBHQSUANC-UHFFFAOYSA-N 4-methoxy-1-nitro-2-(trifluoromethyl)benzene Chemical class COC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 RBEXRIBHQSUANC-UHFFFAOYSA-N 0.000 abstract 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 abstract 1
- BNUHAJGCKIQFGE-UHFFFAOYSA-N Nitroanisol Chemical compound COC1=CC=C([N+]([O-])=O)C=C1 BNUHAJGCKIQFGE-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 230000002862 amidating effect Effects 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 229960004909 aminosalicylic acid Drugs 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001567 anti-fibrinolytic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 238000006480 benzoylation reaction Methods 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000021523 carboxylation Effects 0.000 abstract 1
- 238000006473 carboxylation reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000017858 demethylation Effects 0.000 abstract 1
- 238000010520 demethylation reaction Methods 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004984 dialkylaminoalkoxy group Chemical group 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000005358 mercaptoalkyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- BHAAPTBBJKJZER-UHFFFAOYSA-N p-anisidine Chemical compound COC1=CC=C(N)C=C1 BHAAPTBBJKJZER-UHFFFAOYSA-N 0.000 abstract 1
- 125000002071 phenylalkoxy group Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- JZWFDVDETGFGFC-UHFFFAOYSA-N salacetamide Chemical group CC(=O)NC(=O)C1=CC=CC=C1O JZWFDVDETGFGFC-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83662369A | 1969-06-25 | 1969-06-25 | |
| US3032270A | 1970-04-20 | 1970-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1268465A true GB1268465A (en) | 1972-03-29 |
Family
ID=26705913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2966870A Expired GB1268465A (en) | 1969-06-25 | 1970-06-18 | Substituted salicylic acid compounds |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS4920197B1 (enrdf_load_stackoverflow) |
| CH (1) | CH536278A (enrdf_load_stackoverflow) |
| DE (1) | DE2031227A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2053015A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1268465A (enrdf_load_stackoverflow) |
| NL (1) | NL7008623A (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6573402B1 (en) | 2000-04-20 | 2003-06-03 | Neurotech Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
| KR100639551B1 (ko) | 2005-07-28 | 2006-10-30 | (주)에스에이치제약 | 5-(치환된 페닐알킬)아미노살리실산 화합물의 제조 방법 |
| KR100668111B1 (ko) | 2005-07-28 | 2007-01-12 | (주)에스에이치제약 | 강력한 항산화 효과를 가짐으로써 급성 및 퇴행성 뇌신경계질환의 예방 및 치료에 이용 가능한 신규물질인아미노살리실산 유도체와 그 염의 제조방법 |
| US7189878B2 (en) | 2002-06-19 | 2007-03-13 | Neurotech Co., Ltd. | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same |
| US8686185B2 (en) | 2007-11-12 | 2014-04-01 | Neurotech Pharmaceuticals Co., Ltd. | Manufacturing method of 2-hydroxy-5-phenylalkylaminobenzoic acid derivatives and their salts |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5283169U (enrdf_load_stackoverflow) * | 1975-12-18 | 1977-06-21 | ||
| FR2405241A1 (fr) * | 1977-10-06 | 1979-05-04 | Rorer Inc William H | Benzylideneaniline et ses derives, utilises pour le traitement d'inflammation chez les animaux a sang chaud |
| IT1196348B (it) * | 1984-11-29 | 1988-11-16 | Italfarmaco Spa | Composti ad attivita'antiinfiammatoria |
| DE3668450D1 (de) * | 1985-03-14 | 1990-03-01 | Smithkline Dauelsberg | 5-aminosalicylsaeurederivate von nicht-steroidalen entzuendungshemmenden sauren. |
| IT1244873B (it) * | 1990-09-12 | 1994-09-12 | Depha Team Srl | Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali |
| DE60013491T2 (de) * | 2000-04-19 | 2005-09-01 | Neurotech Co., Ltd., Suwon | Verbindungen, zusammensetzungen und verfahren zur vorbeugung der neurodegeneration bei akuten oder chronischen verletzungen des zentralen nervensystems |
| AU2007239191B2 (en) | 2006-04-13 | 2010-10-28 | Neurotech Pharmaceuticals Co., Ltd. | Pharmaceutical composition for treating or preventing degenerative and inflammatory diseases |
| WO2021006637A1 (ko) * | 2019-07-08 | 2021-01-14 | 주식회사 지엔티파마 | 5-벤질아미노살리실산 유도체를 포함하는 화장품 조성물 및 이의 국소 사용방법 |
-
1970
- 1970-06-12 NL NL7008623A patent/NL7008623A/xx unknown
- 1970-06-18 GB GB2966870A patent/GB1268465A/en not_active Expired
- 1970-06-22 JP JP5358270A patent/JPS4920197B1/ja active Pending
- 1970-06-23 CH CH950370A patent/CH536278A/de not_active IP Right Cessation
- 1970-06-24 DE DE19702031227 patent/DE2031227A1/de active Pending
- 1970-06-24 FR FR7023328A patent/FR2053015A1/fr not_active Withdrawn
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6573402B1 (en) | 2000-04-20 | 2003-06-03 | Neurotech Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
| US6964982B2 (en) | 2000-04-20 | 2005-11-15 | Neurotech Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
| US7750045B2 (en) | 2000-04-20 | 2010-07-06 | Neurotech Pharmaceuticals Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
| US8211878B2 (en) | 2000-04-20 | 2012-07-03 | Neurotech Pharmaceuticals Co., Ltd. | Method for reducing neuronal death in nervous system injuries resulting from amyotrophic lateral sclerosis |
| US8211877B2 (en) | 2000-04-20 | 2012-07-03 | Neurotech Pharmaceuticals Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
| US7189878B2 (en) | 2002-06-19 | 2007-03-13 | Neurotech Co., Ltd. | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same |
| US7319160B2 (en) | 2002-06-19 | 2008-01-15 | Amkor Pharma, Inc. | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same |
| US7371896B2 (en) | 2002-06-19 | 2008-05-13 | Amkor Pharma, Inc. | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same |
| US7511074B2 (en) | 2002-06-19 | 2009-03-31 | Amkor Pharma, Inc. | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same |
| KR100639551B1 (ko) | 2005-07-28 | 2006-10-30 | (주)에스에이치제약 | 5-(치환된 페닐알킬)아미노살리실산 화합물의 제조 방법 |
| KR100668111B1 (ko) | 2005-07-28 | 2007-01-12 | (주)에스에이치제약 | 강력한 항산화 효과를 가짐으로써 급성 및 퇴행성 뇌신경계질환의 예방 및 치료에 이용 가능한 신규물질인아미노살리실산 유도체와 그 염의 제조방법 |
| US8686185B2 (en) | 2007-11-12 | 2014-04-01 | Neurotech Pharmaceuticals Co., Ltd. | Manufacturing method of 2-hydroxy-5-phenylalkylaminobenzoic acid derivatives and their salts |
Also Published As
| Publication number | Publication date |
|---|---|
| CH536278A (de) | 1973-04-30 |
| FR2053015A1 (enrdf_load_stackoverflow) | 1971-04-16 |
| JPS4920197B1 (enrdf_load_stackoverflow) | 1974-05-23 |
| DE2031227A1 (de) | 1971-01-07 |
| NL7008623A (enrdf_load_stackoverflow) | 1970-12-29 |
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