GB1268357A - Polymyxin salts - Google Patents

Polymyxin salts

Info

Publication number
GB1268357A
GB1268357A GB4136668A GB4136668A GB1268357A GB 1268357 A GB1268357 A GB 1268357A GB 4136668 A GB4136668 A GB 4136668A GB 4136668 A GB4136668 A GB 4136668A GB 1268357 A GB1268357 A GB 1268357A
Authority
GB
United Kingdom
Prior art keywords
polymyxin
salt
fatty acid
salts
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4136668A
Inventor
Knud Andersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xellia Pharmaceuticals ApS
Original Assignee
Dumex AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dumex AS filed Critical Dumex AS
Priority to GB4136668A priority Critical patent/GB1268357A/en
Priority to DK440669A priority patent/DK131671C/en
Priority to NO340769A priority patent/NO125888B/no
Priority to FR6928977A priority patent/FR2016565B1/fr
Priority to DE19691943538 priority patent/DE1943538C3/en
Priority to FI248069A priority patent/FI50112C/en
Priority to AT825069A priority patent/AT297922B/en
Priority to SE1190169A priority patent/SE362871B/xx
Priority to CH1315569A priority patent/CH516522A/en
Priority to BE745628D priority patent/BE745628A/en
Publication of GB1268357A publication Critical patent/GB1268357A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1,268,357. Fatty acid salts of polymyxins. DUMEX A.S. 19 Aug., 1969 [29 Aug., 1968], No. 41366/68. Heading C2A. Novel salts of a polymyxin with C 10 -C 24 saturated fatty acids are prepared either by reacting an organic solvent solution of the fatty acid with the free polymyxin base or by mixing together an aqueous solution of an alkali metal salt of the fatty acid and an aqueous solution of a mineral acid salt of the polymyxin. Suitable polymyxins are polymyxin A, B, D or E, or Circulin. Methylene chloride may be the organic solvent, the polymyxin being added as a solid, or as a slurry in the solvent; a gel forms and the solvent is evaporated to leave the required salt. The aqueous reaction may be carried out at 40-60‹ C., and the polymyxin salt precipitates and is filtered off. Polymyxin stearate and palmitate are prepared.
GB4136668A 1968-08-29 1968-08-29 Polymyxin salts Expired GB1268357A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB4136668A GB1268357A (en) 1968-08-29 1968-08-29 Polymyxin salts
DK440669A DK131671C (en) 1968-08-29 1969-08-18 ANALOGICAL PROCEDURE FOR PREPARING POLYMYXIN FATTY ACID SALTS
NO340769A NO125888B (en) 1968-08-29 1969-08-23
FR6928977A FR2016565B1 (en) 1968-08-29 1969-08-25
DE19691943538 DE1943538C3 (en) 1968-08-29 1969-08-27 Salts of the polymyxins with saturated acidic fat
FI248069A FI50112C (en) 1968-08-29 1969-08-27 Process for the preparation of polymyxin salts.
AT825069A AT297922B (en) 1968-08-29 1969-08-28 Process for the preparation of new polymyxin salts
SE1190169A SE362871B (en) 1968-08-29 1969-08-28
CH1315569A CH516522A (en) 1968-08-29 1969-08-29 Process for the preparation of new polymyxin salts
BE745628D BE745628A (en) 1968-08-29 1970-02-06 Antibiotic polymyxine salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4136668A GB1268357A (en) 1968-08-29 1968-08-29 Polymyxin salts

Publications (1)

Publication Number Publication Date
GB1268357A true GB1268357A (en) 1972-03-29

Family

ID=10419359

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4136668A Expired GB1268357A (en) 1968-08-29 1968-08-29 Polymyxin salts

Country Status (9)

Country Link
AT (1) AT297922B (en)
CH (1) CH516522A (en)
DE (1) DE1943538C3 (en)
DK (1) DK131671C (en)
FI (1) FI50112C (en)
FR (1) FR2016565B1 (en)
GB (1) GB1268357A (en)
NO (1) NO125888B (en)
SE (1) SE362871B (en)

Also Published As

Publication number Publication date
FR2016565B1 (en) 1973-01-12
FR2016565A1 (en) 1970-05-08
FI50112B (en) 1975-09-01
DE1943538A1 (en) 1970-08-27
DK131671B (en) 1975-08-18
DE1943538B2 (en) 1973-02-15
DK131671C (en) 1976-01-19
CH516522A (en) 1971-12-15
FI50112C (en) 1975-12-10
DE1943538C3 (en) 1973-09-20
NO125888B (en) 1972-11-20
AT297922B (en) 1972-04-10
SE362871B (en) 1973-12-27

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