GB1261780A - Orally active sulfur-containing cephalosporin antibiotics - Google Patents
Orally active sulfur-containing cephalosporin antibioticsInfo
- Publication number
- GB1261780A GB1261780A GB63526/69A GB6352669A GB1261780A GB 1261780 A GB1261780 A GB 1261780A GB 63526/69 A GB63526/69 A GB 63526/69A GB 6352669 A GB6352669 A GB 6352669A GB 1261780 A GB1261780 A GB 1261780A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- methylthiomethyl
- ester
- group
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 title 1
- 239000011593 sulfur Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 5
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 abstract 4
- -1 N-protected phenylglycine Chemical class 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 3
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- YGBFLZPYDUKSPT-MRVPVSSYSA-N cephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C[C@H]21 YGBFLZPYDUKSPT-MRVPVSSYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000005331 phenylglycines Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80264369A | 1969-02-26 | 1969-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1261780A true GB1261780A (en) | 1972-01-26 |
Family
ID=25184304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB63526/69A Expired GB1261780A (en) | 1969-02-26 | 1969-12-31 | Orally active sulfur-containing cephalosporin antibiotics |
Country Status (17)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4409215A (en) | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7112483A (enrdf_load_stackoverflow) * | 1970-09-14 | 1972-03-16 | ||
| GB1385895A (en) * | 1971-03-01 | 1975-03-05 | Glaxo Lab Ltd | Antibiotics |
| CA1076560A (en) * | 1972-06-14 | 1980-04-29 | Smith Kline And French Canada Ltd. | 3-heterocyclic thiomethylcephalosporins |
-
1969
- 1969-12-05 ZA ZA698494A patent/ZA698494B/xx unknown
- 1969-12-11 IL IL33522A patent/IL33522A0/xx unknown
- 1969-12-15 BR BR215176/69A patent/BR6915176D0/pt unknown
- 1969-12-24 SU SU1389812A patent/SU383302A3/ru active
- 1969-12-24 BE BE743754D patent/BE743754A/xx unknown
- 1969-12-26 GT GT196915584A patent/GT196915584A/es unknown
- 1969-12-26 FR FR6945111A patent/FR2032408B1/fr not_active Expired
- 1969-12-31 GB GB63526/69A patent/GB1261780A/en not_active Expired
- 1969-12-31 NL NL6919698A patent/NL6919698A/xx unknown
-
1970
- 1970-01-02 DE DE19702000111 patent/DE2000111A1/de active Pending
- 1970-01-02 PL PL1970137933A patent/PL80818B1/pl unknown
- 1970-01-06 RO RO62053A patent/RO56960A/ro unknown
- 1970-01-07 LU LU60150D patent/LU60150A1/xx unknown
- 1970-01-07 CH CH10970A patent/CH536321A/de not_active IP Right Cessation
- 1970-01-07 DO DO1970001696A patent/DOP1970001696A/es unknown
- 1970-01-07 AT AT11670A patent/AT296501B/de not_active IP Right Cessation
- 1970-01-07 ES ES375237A patent/ES375237A1/es not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4409215A (en) | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
| US4462999A (en) * | 1979-11-19 | 1984-07-31 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
| US5594132A (en) * | 1979-11-19 | 1997-01-14 | Fujisawa Pharmaceutical Co., Ltd. | 7-acylamino-3-substituted cephalosporanic acid derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| SU383302A3 (enrdf_load_stackoverflow) | 1973-05-25 |
| IL33522A0 (en) | 1970-02-19 |
| RO56960A (enrdf_load_stackoverflow) | 1974-11-11 |
| ZA698494B (en) | 1971-07-28 |
| ES375237A1 (es) | 1972-03-16 |
| DOP1970001696A (es) | 1974-12-09 |
| CH536321A (de) | 1973-04-30 |
| BR6915176D0 (pt) | 1973-02-13 |
| GT196915584A (es) | 1971-06-19 |
| AT296501B (de) | 1972-02-25 |
| DE2000111A1 (de) | 1970-09-10 |
| PL80818B1 (enrdf_load_stackoverflow) | 1975-08-30 |
| LU60150A1 (enrdf_load_stackoverflow) | 1970-07-09 |
| FR2032408A1 (enrdf_load_stackoverflow) | 1970-11-27 |
| BE743754A (enrdf_load_stackoverflow) | 1970-06-24 |
| NL6919698A (enrdf_load_stackoverflow) | 1970-08-28 |
| FR2032408B1 (enrdf_load_stackoverflow) | 1974-02-01 |
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