GB1257097A - - Google Patents

Abstract

1,257,097. Cyclopropylamine. GULF RESEARCH & DEVELOPMENT CO. 6 Aug., 1969 [29 Aug., 1968], No. 39282/69. Heading C2C. Cyclopropylamine is prepared by first adding an alkali metal hypochlorite to an aqueous solution of cyclopropane-carboxamide to yield an intermediate reaction mixture wherein substantial conversion to the alkali metal cyclopropane carboxylate has been prevented and then reacting the intermediate reaction mixture with an alkali metal hydroxide to yield a reaction mixture containing cyclopropylamine in aqueous solution. The cyclopropane carboxamide may be prepared by (a) reacting a lower alkyl C 1-4 4-chloro butyrate with an alkali metal alkoxide in an inert organic liquid to yield a reaction mixture containing lower alkyl C 1-4 cyclopropane carboxylate, (b) reacting ammonia with the reaction mixture from step (a) in the presence of alkali metal alkoxide and a lower alkanol C 1-4 to yield a reaction mixture containing cyclopropane carboxamide, (c) removing the lower alkanol C 1-4 and unreacted ammonia and ester by distillation to yield an overhead distillate, (d) adding water to the residual mixture and separating the organic phase and an aqueous solution of cyclopropane carboxamide, (e) recycling the organic phase to step (a).