GB1238971A - - Google Patents
Info
- Publication number
- GB1238971A GB1238971A GB1238971DA GB1238971A GB 1238971 A GB1238971 A GB 1238971A GB 1238971D A GB1238971D A GB 1238971DA GB 1238971 A GB1238971 A GB 1238971A
- Authority
- GB
- United Kingdom
- Prior art keywords
- histidine
- peptide
- prepared
- alkali metal
- protecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/068—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for heterocyclic side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1,238,971. Histidine containing peptides. FARBWERKE HOECHST A.G. 3 March, 1969 [2 March, 1968], No. 11239/69. Heading C2C. Peptides containing at least one histidine unit are prepared by treating a peptide containing a substituted histidine unit of the formula (wherein R 1 and R 2 each represent an alkyl, aralkyl or aryl group and in which the groups represented by R 1 and R 2 may be the same or different, or in which NR 1 R 2 represents a heterocyclic ring) with (a) NH 3 , a primary or secondary amine, a hydrazine or a hydrazine derivative having at least one -NH-group or (b) an alkali metal or alkaline earth metal hydroxide or (c) an alkali metal or alkaline earth metal and liquid NH 3 or (d) an alkali metal alcoholate. The protected histidine containing peptides are prepared by reacting an N<SP>α</SP>-acyl histidine ester with a substituted carbamoyl chloride in the presence of an acid binding agent and then building the peptide by known methods or by acylating the N<SP>Im</SP> atom in an otherwise fully protected histidine-containing peptide with a carbamoyl halide. Protecting groups other than the carbamoyl groups protecting the N<SP>Im</SP> atom of histidine may be removed by known means before or after removing the N<SP>Im</SP> protecting group. Z-His-OBzl and Z-Phe-His-OBzl are prepared as starting materials. Pharmaceutical compositions comprise a histidine peptide of the invention together with a suitable carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1668905 | 1968-03-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1238971A true GB1238971A (en) | 1971-07-14 |
Family
ID=5686155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1238971D Expired GB1238971A (en) | 1968-03-02 | 1969-03-03 |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1238971A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015528013A (en) * | 2012-07-27 | 2015-09-24 | ビアル−ポルテラ エ コンパニア，ソシエダッド アノニマ | Method for synthesizing substituted urea compounds |
-
1969
- 1969-03-03 GB GB1238971D patent/GB1238971A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015528013A (en) * | 2012-07-27 | 2015-09-24 | ビアル−ポルテラ エ コンパニア，ソシエダッド アノニマ | Method for synthesizing substituted urea compounds |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |