GB1234100A - - Google Patents

Info

Publication number
GB1234100A
GB1234100A GB1234100DA GB1234100A GB 1234100 A GB1234100 A GB 1234100A GB 1234100D A GB1234100D A GB 1234100DA GB 1234100 A GB1234100 A GB 1234100A
Authority
GB
United Kingdom
Prior art keywords
compounds
cyclohexenyl
aug
prepared
pancaval
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1234100A publication Critical patent/GB1234100A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1,234,100. Substituted guanamines. ARMOUR PHARMACEUTICAL CO. 15 Aug., 1968 [16 Aug., 1967], No. 39087/68. Heading C2C. [Also in Division A5] The invention comprises compounds of formula and their non-toxic acid addition salts, wherein R is C 3-5 or C 7-10 cycloalkyl, 1- or 2-cyclohexenyl, norbornyl, or phenylcyclopropyl. These compounds are prepared by refluxing RCN with dicyandiamide, in ethyleneglycol mono-methyl or -ethyl ether, in presence of a basic catalyst such as KOH. In Example V, 6 - cyclohexylguanamine is prepared by hydrogenating 6- (3<SP>1</SP>-cyclohexenyl)guanamine. Therapeutic compositions for treating inflammatory conditions comprise the above compounds with conventional adjuvants. Administration may be oral, topical, intravenous or pancaval.
GB1234100D 1967-08-16 1968-08-15 Expired GB1234100A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66091967A 1967-08-16 1967-08-16

Publications (1)

Publication Number Publication Date
GB1234100A true GB1234100A (en) 1971-06-03

Family

ID=24651486

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1234100D Expired GB1234100A (en) 1967-08-16 1968-08-15

Country Status (3)

Country Link
US (1) US3478026A (en)
FR (1) FR7635M (en)
GB (1) GB1234100A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2133402A (en) * 1982-12-10 1984-07-25 Nippon Shinyaku Co Ltd Triazine derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150362A (en) * 1997-12-12 2000-11-21 Henkin; Jack Triazine angiogenesis inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2527314A (en) * 1950-10-24 Production of guanamines
US2305217A (en) * 1942-12-15 Process of cubing surface covering
US2385765A (en) * 1941-08-30 1945-09-25 American Cyanamid Co Textile finishing
US2859188A (en) * 1956-11-26 1958-11-04 Monsanto Chemicals Hexahydrobenzoguanamine oil modified alkyd coating compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2133402A (en) * 1982-12-10 1984-07-25 Nippon Shinyaku Co Ltd Triazine derivatives

Also Published As

Publication number Publication date
US3478026A (en) 1969-11-11
FR7635M (en) 1970-01-26

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees