GB1232758A - - Google Patents
Info
- Publication number
- GB1232758A GB1232758A GB1232758DA GB1232758A GB 1232758 A GB1232758 A GB 1232758A GB 1232758D A GB1232758D A GB 1232758DA GB 1232758 A GB1232758 A GB 1232758A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- amino
- diamino
- alkyl
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- YJAWUVTYYAXOQY-UHFFFAOYSA-N 6-amino-5-chloro-1,3-dihydroimidazo[4,5-b]pyrazin-2-one Chemical class NC=1N=C2C(=NC1Cl)NC(N2)=O YJAWUVTYYAXOQY-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- -1 chlorocarbonyl compound Chemical class 0.000 abstract 2
- OCSQJDAUOOHJEI-UHFFFAOYSA-N 3,5-diamino-6-chloropyrazine-2-carboxylic acid Chemical compound NC1=NC(N)=C(C(O)=O)N=C1Cl OCSQJDAUOOHJEI-UHFFFAOYSA-N 0.000 abstract 1
- RNCLSXKCEOOGOH-UHFFFAOYSA-N 3-chloro-5-nitropyrazine-2,6-diamine Chemical compound NC1=NC(N)=C([N+]([O-])=O)N=C1Cl RNCLSXKCEOOGOH-UHFFFAOYSA-N 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006114 decarboxylation reaction Methods 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- KOOBYHRLTYIPTH-UHFFFAOYSA-N methyl 3,5-diamino-6-chloropyrazine-2-carboxylate Chemical compound COC(=O)C1=NC(Cl)=C(N)N=C1N KOOBYHRLTYIPTH-UHFFFAOYSA-N 0.000 abstract 1
- USYMCUGEGUFUBI-UHFFFAOYSA-N methyl 3-amino-5,6-dichloropyrazine-2-carboxylate Chemical compound COC(=O)C1=NC(Cl)=C(Cl)N=C1N USYMCUGEGUFUBI-UHFFFAOYSA-N 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA28996 | 1968-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1232758A true GB1232758A (enrdf_load_stackoverflow) | 1971-05-19 |
Family
ID=4084474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1232758D Expired GB1232758A (enrdf_load_stackoverflow) | 1968-08-31 | 1969-08-25 |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | AT289813B (enrdf_load_stackoverflow) |
| BR (1) | BR6911906D0 (enrdf_load_stackoverflow) |
| CH (1) | CH517763A (enrdf_load_stackoverflow) |
| ES (1) | ES370874A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1232758A (enrdf_load_stackoverflow) |
| NL (1) | NL6911867A (enrdf_load_stackoverflow) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4414215A (en) * | 1981-08-24 | 1983-11-08 | Merck & Co., Inc. | N-Acyl derivatives of 6-alkylamino 5-chloro-3-nitropyrazinamines for radiation therapy |
| US4418062A (en) * | 1981-08-24 | 1983-11-29 | Merck & Co., Inc. | Amino derivatives of chloro nitro amino pyrazines useful as adjuncts to radiation therapy |
| EP0096125A1 (en) * | 1982-06-09 | 1983-12-21 | Merck & Co. Inc. | Amino and amido derivatives of chloro nitro amino and alkylamino pyrazines useful as adjuncts to radiation therapy |
| US4438266A (en) | 1982-05-17 | 1984-03-20 | Merck & Co., Inc. | Triazolopyrazinamines useful as adjuncts to radiation therapy |
| US4609659A (en) * | 1985-01-16 | 1986-09-02 | Merck & Co., Inc. | 2,6-disubstituted derivatives of 3-nitropyrazines useful as adjuncts to radiation therapy |
| US4709035A (en) * | 1982-11-12 | 1987-11-24 | Merck & Co., Inc. | 2,6-disubstituted derivatives of 3-nitropyrazines useful as adjuncts to radiation therapy |
-
1969
- 1969-08-04 NL NL6911867A patent/NL6911867A/xx unknown
- 1969-08-19 CH CH1254569A patent/CH517763A/de unknown
- 1969-08-25 GB GB1232758D patent/GB1232758A/en not_active Expired
- 1969-08-26 ES ES370874A patent/ES370874A1/es not_active Expired
- 1969-08-27 BR BR21190669A patent/BR6911906D0/pt unknown
- 1969-08-29 AT AT829969A patent/AT289813B/de not_active IP Right Cessation
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4414215A (en) * | 1981-08-24 | 1983-11-08 | Merck & Co., Inc. | N-Acyl derivatives of 6-alkylamino 5-chloro-3-nitropyrazinamines for radiation therapy |
| US4418062A (en) * | 1981-08-24 | 1983-11-29 | Merck & Co., Inc. | Amino derivatives of chloro nitro amino pyrazines useful as adjuncts to radiation therapy |
| US4438266A (en) | 1982-05-17 | 1984-03-20 | Merck & Co., Inc. | Triazolopyrazinamines useful as adjuncts to radiation therapy |
| EP0096125A1 (en) * | 1982-06-09 | 1983-12-21 | Merck & Co. Inc. | Amino and amido derivatives of chloro nitro amino and alkylamino pyrazines useful as adjuncts to radiation therapy |
| US4709035A (en) * | 1982-11-12 | 1987-11-24 | Merck & Co., Inc. | 2,6-disubstituted derivatives of 3-nitropyrazines useful as adjuncts to radiation therapy |
| US4609659A (en) * | 1985-01-16 | 1986-09-02 | Merck & Co., Inc. | 2,6-disubstituted derivatives of 3-nitropyrazines useful as adjuncts to radiation therapy |
Also Published As
| Publication number | Publication date |
|---|---|
| BR6911906D0 (pt) | 1973-01-18 |
| NL6911867A (enrdf_load_stackoverflow) | 1970-03-03 |
| ES370874A1 (es) | 1971-10-16 |
| CH517763A (de) | 1972-01-15 |
| AT289813B (de) | 1971-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |