GB1218600A - Improvements in or relating to erythromycylamine acyl derivatives - Google Patents
Improvements in or relating to erythromycylamine acyl derivativesInfo
- Publication number
- GB1218600A GB1218600A GB3343568A GB3343568A GB1218600A GB 1218600 A GB1218600 A GB 1218600A GB 3343568 A GB3343568 A GB 3343568A GB 3343568 A GB3343568 A GB 3343568A GB 1218600 A GB1218600 A GB 1218600A
- Authority
- GB
- United Kingdom
- Prior art keywords
- erythromycylamine
- formula
- acyl
- chloride
- mono
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XCLJRCAJSCMIND-JCTYMORFSA-N (9S)-erythromycyclamine Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)[C@@H](N)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 XCLJRCAJSCMIND-JCTYMORFSA-N 0.000 abstract 4
- -1 aromatic mono carboxylic acid Chemical class 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- QZIQJVCYUQZDIR-UHFFFAOYSA-N mechlorethamine hydrochloride Chemical compound Cl.ClCCN(C)CCCl QZIQJVCYUQZDIR-UHFFFAOYSA-N 0.000 abstract 1
- UOBSVARXACCLLH-UHFFFAOYSA-N monomethyl adipate Chemical class COC(=O)CCCCC(O)=O UOBSVARXACCLLH-UHFFFAOYSA-N 0.000 abstract 1
- JDRMYOQETPMYQX-UHFFFAOYSA-N monomethyl succinate Chemical class COC(=O)CCC(O)=O JDRMYOQETPMYQX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,218,600. Acyl derivatives of erythromycylamine. PLIVA PHARMACEUTICAL & CHEMICAL WORKS. 12 July, 1968 [3 Aug., 1967], No. 33435/68. Heading C2A. The invention comprises mono-acyl and bisacyl derivatives of erythromycylamine, wherein the acyl group is derived from an aliphatic or aromatic mono carboxylic acid chloride of formula RCOC1 wherein R is an alkyl radical having 2 to 17 carbon atoms or a phenyl radical, or a dicarboxylic acid ester chloride of formula ClOC(CH 2 ) n -COOR<SP>1</SP> wherein <SP>R1</SP> is CH 3 or C 2 H 5 and n is 1 to 4. Typical examples are the mono- and bis-propionates, methyl succinates and methyl adipates of erythromycylamine. The compounds are prepared by acylating erythromycylamine with the appropriate acid chloride or acid ester chloride in an inert organic solvent in the presence of an alkali metal salt e.g. NaHCO 3 . Erythromycylamine has the formula and is described and claimed in Specification 1,100,504.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU1184767 | 1967-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1218600A true GB1218600A (en) | 1971-01-06 |
Family
ID=25559705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3343568A Expired GB1218600A (en) | 1967-08-03 | 1968-07-12 | Improvements in or relating to erythromycylamine acyl derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1218600A (en) |
-
1968
- 1968-07-12 GB GB3343568A patent/GB1218600A/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1490603A (en) | Glycerides with anti-inflammatory properties | |
| GB1121027A (en) | New carboxylic acid derivatives, processes for the preparation thereof and compositions containing the same | |
| GB1131498A (en) | Niconitic acid esters | |
| GB1218600A (en) | Improvements in or relating to erythromycylamine acyl derivatives | |
| FR2356631A1 (en) | NEW DERIVATIVES OF N-SUBSTITUTED CARBOXYLIC ACID AMIDES | |
| ES432288A1 (en) | Ergopeptine derivatives | |
| KR870003107A (en) | Method for preparing chianthine derivative | |
| GB1201631A (en) | Novel n-substituted amides | |
| GB1221088A (en) | Improvements in or relating to erythromycin oxime acyl derivatives | |
| GB1157100A (en) | Pharmaceutical Compositions | |
| JPS523046A (en) | Prepration of 4-homotwistane-3-carboxylic acid esters | |
| GB1305820A (en) | ||
| GB1422216A (en) | Phenyl-formamidine derivatives | |
| GB1277445A (en) | Novel phenanthridine derivatives | |
| FR2370038A1 (en) | OXIME DERIVATIVES OF 4- (D-3-AMINO-3-CARBOXYPROPOXY) PHENYLGLYOXYLIC ACID, CONSTITUTING THE SIDE CHAIN OF THE ANTIBIOTIC NOCARDICIN | |
| ES428672A1 (en) | Diamine-benzophenones and a process for the preparation thereof | |
| ES467237A1 (en) | Derivatives of cyclopropane | |
| ES314738A1 (en) | Procedure for the preparation of new derivatives of oxepine. (Machine-translation by Google Translate, not legally binding) | |
| GB1313903A (en) | Phosphoric acid amide esters | |
| GB1144022A (en) | Improvements in or relating to organic compounds | |
| GB1324687A (en) | 3-amino-delta2-pyrazoline derivatives and process for the preparation thereof | |
| GB1417996A (en) | Maleopimarimide derivatives | |
| FR2369268A1 (en) | TRANS-5A-ARYL-DECAHYDRO-BENZAZEPINES WITH ANALGESIC ACTIVITY | |
| GB1430188A (en) | Diaza-oxa-bicyclodecane derivatives | |
| GB1108918A (en) | 2-imidazolidone derivatives |