GB1202521A - 01beta-CHLORO-19-NOR-STEROIDS - Google Patents
01beta-CHLORO-19-NOR-STEROIDSInfo
- Publication number
- GB1202521A GB1202521A GB23066/67A GB2306667A GB1202521A GB 1202521 A GB1202521 A GB 1202521A GB 23066/67 A GB23066/67 A GB 23066/67A GB 2306667 A GB2306667 A GB 2306667A GB 1202521 A GB1202521 A GB 1202521A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- dione
- steroid
- reaction
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000460 chlorine Substances 0.000 abstract 6
- 238000006243 chemical reaction Methods 0.000 abstract 5
- 229910052801 chlorine Inorganic materials 0.000 abstract 5
- 230000007062 hydrolysis Effects 0.000 abstract 3
- 238000006460 hydrolysis reaction Methods 0.000 abstract 3
- 238000006027 Birch reduction reaction Methods 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 150000002085 enols Chemical class 0.000 abstract 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 abstract 2
- UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 abstract 2
- GJONCRUTYWCGQZ-YDWUEFBCSA-N (8S,9S,10R,11R,13S,14S)-3-ethoxy-11-hydroxy-13-methyl-2,7,8,9,10,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-one Chemical compound C(C)OC1=CC2=CC[C@H]3[C@@H]4CCC([C@@]4(C)C[C@H]([C@@H]3[C@H]2CC1)O)=O GJONCRUTYWCGQZ-YDWUEFBCSA-N 0.000 abstract 1
- IFVVGMVAZUNKPN-SJFWLOONSA-N (8S,9S,10R,13R,14S,17R)-17-(2-iodoethyl)-10,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene Chemical compound ICC[C@H]1CC[C@H]2[C@@H]3CCC4=CCC=C[C@]4(C)[C@H]3CC[C@]12C IFVVGMVAZUNKPN-SJFWLOONSA-N 0.000 abstract 1
- -1 20,20 - ethylenedioxy Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 229930194542 Keto Natural products 0.000 abstract 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Natural products P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000001348 alkyl chlorides Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006266 etherification reaction Methods 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000006197 hydroboration reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000002902 organometallic compounds Chemical class 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 229960001124 trientine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB23066/67A GB1202521A (en) | 1966-07-29 | 1966-07-29 | 01beta-CHLORO-19-NOR-STEROIDS |
| PL1967121900A PL79253B1 (enrdf_load_stackoverflow) | 1966-07-29 | 1967-07-27 | |
| AT706867A AT301766B (de) | 1966-07-29 | 1967-07-28 | Verfahren zur Herstellung von neuen 9α-unsubstituierten 11β-Chlor-19-nor-steroiden |
| DE1967G0050758 DE1668124B2 (de) | 1966-07-29 | 1967-07-28 | 9 alpha-unsubstituierte 11 beta- chlor-19-norsteroide, verfahren zu deren herstellung sowie diese enthaltende pharmazeutische zusammensetzungen |
| DK389767AA DK129004B (da) | 1966-07-29 | 1967-07-28 | Analogifremgangsmåde til fremstilling af 9α-usubstituerede 11β-klor-19-norsteroider af østran- eller 19-norpregnanrækken. |
| SE10939/67*A SE349025B (enrdf_load_stackoverflow) | 1966-07-29 | 1967-07-28 | |
| AT851569A AT311564B (de) | 1966-07-29 | 1967-07-28 | Verfahen zur Herstellung von neuen in 9α-Stellung unsubstituierten 6,11β-Dichlor-19-norsteroid-4-en (bzw. 4,6-dien)-3-onen |
| BE702023D BE702023A (enrdf_load_stackoverflow) | 1966-07-29 | 1967-07-28 | |
| FR1565340D FR1565340A (enrdf_load_stackoverflow) | 1966-07-29 | 1967-07-28 | |
| IL28411A IL28411A (en) | 1966-07-29 | 1967-07-28 | 9alpha-unsubstituted 11beta-chloro-19-nor-steroids and their preparation |
| JP42048203A JPS5021469B1 (enrdf_load_stackoverflow) | 1966-07-29 | 1967-07-28 | |
| NL6710459A NL6710459A (enrdf_load_stackoverflow) | 1966-07-29 | 1967-07-28 | |
| CH1075067A CH580644A5 (enrdf_load_stackoverflow) | 1966-07-29 | 1967-07-28 | |
| FR125405A FR7812M (enrdf_load_stackoverflow) | 1966-07-29 | 1967-08-23 | |
| US846975A US3665021A (en) | 1966-07-29 | 1969-08-01 | 9alpha-unsubstituted-11beta-chloro-l9 nos-steroids |
| DK483769AA DK131295B (da) | 1966-07-29 | 1969-09-10 | Steroider af østran- eller 19-norpregnanrækken til brug som svangerskabsforebyggende midler. |
| SE06851/70A SE350488B (enrdf_load_stackoverflow) | 1966-07-29 | 1970-05-19 | |
| JP45075642A JPS5224013B1 (enrdf_load_stackoverflow) | 1966-07-29 | 1970-08-31 | |
| CH1075067A CH584724A5 (enrdf_load_stackoverflow) | 1966-07-29 | 1975-08-15 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3427566 | 1966-07-29 | ||
| GB23066/67A GB1202521A (en) | 1966-07-29 | 1966-07-29 | 01beta-CHLORO-19-NOR-STEROIDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1202521A true GB1202521A (en) | 1970-08-19 |
Family
ID=26256295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23066/67A Expired GB1202521A (en) | 1966-07-29 | 1966-07-29 | 01beta-CHLORO-19-NOR-STEROIDS |
Country Status (12)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1289521A (enrdf_load_stackoverflow) * | 1969-01-23 | 1972-09-20 | ||
| GB1313659A (en) * | 1969-07-25 | 1973-04-18 | Glaxo Lab Ltd | 9alpha-unsubstituted-11beta-chloro-19-norpregnane compounds |
| JPS5090183A (enrdf_load_stackoverflow) * | 1973-12-14 | 1975-07-19 | ||
| JPS5090184A (enrdf_load_stackoverflow) * | 1973-12-14 | 1975-07-19 |
-
1966
- 1966-07-29 GB GB23066/67A patent/GB1202521A/en not_active Expired
-
1967
- 1967-07-27 PL PL1967121900A patent/PL79253B1/pl unknown
- 1967-07-28 AT AT851569A patent/AT311564B/de not_active IP Right Cessation
- 1967-07-28 SE SE10939/67*A patent/SE349025B/xx unknown
- 1967-07-28 FR FR1565340D patent/FR1565340A/fr not_active Expired
- 1967-07-28 DE DE1967G0050758 patent/DE1668124B2/de active Granted
- 1967-07-28 IL IL28411A patent/IL28411A/en unknown
- 1967-07-28 BE BE702023D patent/BE702023A/xx unknown
- 1967-07-28 AT AT706867A patent/AT301766B/de not_active IP Right Cessation
- 1967-07-28 JP JP42048203A patent/JPS5021469B1/ja active Pending
- 1967-07-28 CH CH1075067A patent/CH580644A5/xx not_active IP Right Cessation
- 1967-07-28 DK DK389767AA patent/DK129004B/da unknown
- 1967-07-28 NL NL6710459A patent/NL6710459A/xx unknown
- 1967-08-23 FR FR125405A patent/FR7812M/fr not_active Expired
-
1969
- 1969-09-10 DK DK483769AA patent/DK131295B/da unknown
-
1970
- 1970-05-19 SE SE06851/70A patent/SE350488B/xx unknown
- 1970-08-31 JP JP45075642A patent/JPS5224013B1/ja active Pending
-
1975
- 1975-08-15 CH CH1075067A patent/CH584724A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE1668124B2 (de) | 1976-10-07 |
| DK131295C (enrdf_load_stackoverflow) | 1975-11-17 |
| FR7812M (enrdf_load_stackoverflow) | 1970-05-20 |
| CH584724A5 (enrdf_load_stackoverflow) | 1977-02-15 |
| AT301766B (de) | 1972-09-25 |
| FR1565340A (enrdf_load_stackoverflow) | 1969-05-02 |
| IL28411A (en) | 1972-07-26 |
| BE702023A (enrdf_load_stackoverflow) | 1968-01-29 |
| SE350488B (enrdf_load_stackoverflow) | 1972-10-30 |
| NL6710459A (enrdf_load_stackoverflow) | 1968-01-30 |
| SE349025B (enrdf_load_stackoverflow) | 1972-09-18 |
| DE1668124A1 (de) | 1971-05-06 |
| JPS5224013B1 (enrdf_load_stackoverflow) | 1977-06-28 |
| AT311564B (de) | 1973-11-26 |
| DK129004B (da) | 1974-08-05 |
| PL79253B1 (enrdf_load_stackoverflow) | 1975-06-30 |
| DK131295B (da) | 1975-06-23 |
| CH580644A5 (enrdf_load_stackoverflow) | 1976-10-15 |
| JPS5021469B1 (enrdf_load_stackoverflow) | 1975-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |