GB1304395A - - Google Patents
Info
- Publication number
- GB1304395A GB1304395A GB1773170A GB1773170A GB1304395A GB 1304395 A GB1304395 A GB 1304395A GB 1773170 A GB1773170 A GB 1773170A GB 1773170 A GB1773170 A GB 1773170A GB 1304395 A GB1304395 A GB 1304395A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- ene
- difluoro
- tetrahydropyran
- products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JRIZOGLBRPZBLQ-QXUSFIETSA-N 19-Norandrostenedione Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JRIZOGLBRPZBLQ-QXUSFIETSA-N 0.000 abstract 3
- YFEXZJKJPFNYKB-UHFFFAOYSA-N 2-(oxolan-2-yloxy)oxolane Chemical compound C1CCOC1OC1OCCC1 YFEXZJKJPFNYKB-UHFFFAOYSA-N 0.000 abstract 3
- -1 R<SP>2</SP> is H Chemical group 0.000 abstract 3
- 150000003431 steroids Chemical class 0.000 abstract 3
- QYLJNAMKKXVXBU-JAYZULETSA-N (8r,9s,10r,13s,14s)-3-ethoxy-13-methyl-2,7,8,9,10,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-one Chemical compound C1C[C@@H]2[C@@H](CCC(OCC)=C3)C3=CC[C@H]2[C@@H]2CCC(=O)[C@]21C QYLJNAMKKXVXBU-JAYZULETSA-N 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
- 125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 2
- SBYZSMHTTSGGLZ-JRRWAFEKSA-N (8R,9S,10R,13S,14S)-3-ethoxy-6-fluoro-13-methyl-2,7,8,9,10,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-one Chemical compound C(C)OC1=CC2=C(C[C@H]3[C@@H]4CCC([C@@]4(C)CC[C@@H]3[C@H]2CC1)=O)F SBYZSMHTTSGGLZ-JRRWAFEKSA-N 0.000 abstract 1
- ODIGIKRIUKFKHP-UHFFFAOYSA-N (n-propan-2-yloxycarbonylanilino) acetate Chemical compound CC(C)OC(=O)N(OC(C)=O)C1=CC=CC=C1 ODIGIKRIUKFKHP-UHFFFAOYSA-N 0.000 abstract 1
- HUHXLHLWASNVDB-UHFFFAOYSA-N 2-(oxan-2-yloxy)oxane Chemical compound O1CCCCC1OC1OCCCC1 HUHXLHLWASNVDB-UHFFFAOYSA-N 0.000 abstract 1
- 229910001115 Zinc-copper couple Inorganic materials 0.000 abstract 1
- MMRCJCLZGKVXRJ-KLKSJOQXSA-N [acetyloxy-[(8R,9S,10R,13R,14S,17S)-6,6-difluoro-17-(3-hydroxyprop-1-ynyl)-2,3,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-13-yl]methyl] acetate Chemical compound C(C)(=O)OC([C@@]12[C@@H](CC[C@H]1[C@@H]1CC(C3=CCCC[C@@H]3[C@H]1CC2)(F)F)C#CCO)OC(C)=O MMRCJCLZGKVXRJ-KLKSJOQXSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001441 androstanes Chemical class 0.000 abstract 1
- 150000001443 androstenes Chemical class 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001844 chromium Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- TVZPLCNGKSPOJA-UHFFFAOYSA-N copper zinc Chemical compound [Cu].[Zn] TVZPLCNGKSPOJA-UHFFFAOYSA-N 0.000 abstract 1
- GRXPVLPQNMUNNX-MHJRRCNVSA-N estrane Chemical compound C1CC2CCCC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 GRXPVLPQNMUNNX-MHJRRCNVSA-N 0.000 abstract 1
- OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
- 230000001072 progestational effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81756269A | 1969-04-18 | 1969-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1304395A true GB1304395A (enrdf_load_stackoverflow) | 1973-01-24 |
Family
ID=25223361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1773170A Expired GB1304395A (enrdf_load_stackoverflow) | 1969-04-18 | 1970-04-14 |
Country Status (14)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113788872A (zh) * | 2021-11-03 | 2021-12-14 | 湖北共同药业股份有限公司 | 一种雄甾-2-烯-17-酮的制备方法 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE755860A (fr) * | 1970-06-11 | 1971-02-15 | Syntex Corp | Propadienyl-steroides alcoyl-substitues en c-17 alpha, nouveauxderives de ceux-ci et procede utilisable pour la preparation de ces composes |
-
1970
- 1970-04-02 IL IL34227A patent/IL34227A/xx unknown
- 1970-04-13 FI FI701015A patent/FI47883C/fi active
- 1970-04-13 ZA ZA702449A patent/ZA702449B/xx unknown
- 1970-04-14 GB GB1773170A patent/GB1304395A/en not_active Expired
- 1970-04-15 DE DE19702018087 patent/DE2018087A1/de active Pending
- 1970-04-15 CH CH560370A patent/CH539029A/de not_active IP Right Cessation
- 1970-04-15 AT AT343070A patent/AT301770B/de not_active IP Right Cessation
- 1970-04-16 BE BE749066D patent/BE749066A/xx unknown
- 1970-04-17 SE SE05321/70A patent/SE355577B/xx unknown
- 1970-04-17 NO NO1468/70A patent/NO133975C/no unknown
- 1970-04-17 NL NL7005603A patent/NL7005603A/xx unknown
- 1970-04-17 FR FR7014097A patent/FR2042347B1/fr not_active Expired
- 1970-04-17 ES ES378763A patent/ES378763A1/es not_active Expired
- 1970-04-17 JP JP45032882A patent/JPS4925670B1/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113788872A (zh) * | 2021-11-03 | 2021-12-14 | 湖北共同药业股份有限公司 | 一种雄甾-2-烯-17-酮的制备方法 |
| CN113788872B (zh) * | 2021-11-03 | 2024-02-09 | 湖北共同药业股份有限公司 | 一种雄甾-2-烯-17-酮的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AT301770B (de) | 1972-09-25 |
| FR2042347A1 (enrdf_load_stackoverflow) | 1971-02-12 |
| IL34227A0 (en) | 1970-06-17 |
| NO133975C (enrdf_load_stackoverflow) | 1976-07-28 |
| JPS4925670B1 (enrdf_load_stackoverflow) | 1974-07-02 |
| ZA702449B (en) | 1971-11-24 |
| NO133975B (enrdf_load_stackoverflow) | 1976-04-20 |
| FR2042347B1 (enrdf_load_stackoverflow) | 1974-08-30 |
| CH539029A (de) | 1973-07-15 |
| SE355577B (enrdf_load_stackoverflow) | 1973-04-30 |
| IL34227A (en) | 1974-09-10 |
| ES378763A1 (es) | 1973-02-01 |
| FI47883C (fi) | 1974-04-10 |
| BE749066A (fr) | 1970-10-01 |
| NL7005603A (enrdf_load_stackoverflow) | 1970-10-20 |
| DE2018087A1 (de) | 1970-10-22 |
| FI47883B (enrdf_load_stackoverflow) | 1974-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |