GB1313659A - 9alpha-unsubstituted-11beta-chloro-19-norpregnane compounds - Google Patents

9alpha-unsubstituted-11beta-chloro-19-norpregnane compounds

Info

Publication number
GB1313659A
GB1313659A GB3761269A GB1313659DA GB1313659A GB 1313659 A GB1313659 A GB 1313659A GB 3761269 A GB3761269 A GB 3761269A GB 1313659D A GB1313659D A GB 1313659DA GB 1313659 A GB1313659 A GB 1313659A
Authority
GB
United Kingdom
Prior art keywords
halogen
aralkylidenedioxy
alkylidenedioxy
alkylthio
july
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3761269A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of GB1313659A publication Critical patent/GB1313659A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Abstract

1313659 Pharmaceutical compositions containing steroids GLAXO LABORATORIES Ltd 13 July 1970 [25 July 1969] 37612/69 Heading ASB [Also in Division C2] Pharmaceutical and veterinary compositions comprise steroids possessing progestational, anti-estrogenic and anti-androgenic activity and having the formula: (wherein #<SP>6</SP> is optional, R<SP>1</SP> is H or halogen, R<SP>2</SP> is H, OH or C 1-6 alkoxy or acyloxy, R<SP>3</SP> is H, halogen or C 1-6 alkylthio, or R<SP>2</SP> and R<SP>3</SP> together are alkylidenedioxy or aralkylidenedioxy, and R<SP>4</SP> is H, F, Cl or CH 3 , but R<SP>1</SP> is not H unless (a) R<SP>2</SP> is formyloxy or alkoxy, or (b) R<SP>3</SP> is halogen or alkylthio, or (c) R<SP>2</SP> and R<SP>3</SP> together are alkylidenedioxy or aralkylidenedioxy or (d) R<SP>4</SP> is F or CH 3 ) or 3, 5- dienol ethers or esters thereof, together with carriers or excipients and/or one or more estrogenic hormones e.g. ethynyl-estradiol. They may be used as oral contraceptive agents and in the treatment of such conditions as dysmenorrhoea, functional uterine bleeding, premenstrual tension, diagnosis of pregnancy, endometriosis and threatened or habitual abortion. Oral and rectal dosage forms implants, and injection preparations are described.
GB3761269A 1969-07-25 1969-07-25 9alpha-unsubstituted-11beta-chloro-19-norpregnane compounds Expired GB1313659A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3761269 1969-07-25

Publications (1)

Publication Number Publication Date
GB1313659A true GB1313659A (en) 1973-04-18

Family

ID=10397738

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3761269A Expired GB1313659A (en) 1969-07-25 1969-07-25 9alpha-unsubstituted-11beta-chloro-19-norpregnane compounds

Country Status (9)

Country Link
JP (1) JPS4831107B1 (en)
BR (1) BR6915284D0 (en)
CA (1) CA935429A (en)
DE (1) DE2036908C3 (en)
DK (1) DK128317B (en)
FR (1) FR2059570B1 (en)
GB (1) GB1313659A (en)
NL (1) NL7010980A (en)
ZA (1) ZA705120B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1202521A (en) * 1966-07-29 1970-08-19 Glaxo Lab Ltd 01beta-CHLORO-19-NOR-STEROIDS

Also Published As

Publication number Publication date
ZA705120B (en) 1971-05-27
BR6915284D0 (en) 1973-02-08
DE2036908A1 (en) 1971-02-04
DE2036908B2 (en) 1979-06-13
FR2059570A1 (en) 1971-06-04
FR2059570B1 (en) 1974-09-20
DK128317B (en) 1974-04-08
NL7010980A (en) 1971-01-27
CA935429A (en) 1973-10-16
DE2036908C3 (en) 1980-02-07
JPS4831107B1 (en) 1973-09-26

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Legal Events

Date Code Title Description
PS Patent sealed
426 Order made revoking patent and granting patent of addition in lieu thereof (sect. 26(2)/1949)
PCNP Patent ceased through non-payment of renewal fee