GB1202001A - 6alpha,9alpha-DIFLUOROPREDNISOLONE 17,21-DIESTERS - Google Patents
6alpha,9alpha-DIFLUOROPREDNISOLONE 17,21-DIESTERSInfo
- Publication number
- GB1202001A GB1202001A GB2817668A GB2817668A GB1202001A GB 1202001 A GB1202001 A GB 1202001A GB 2817668 A GB2817668 A GB 2817668A GB 2817668 A GB2817668 A GB 2817668A GB 1202001 A GB1202001 A GB 1202001A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compounds
- difluoroprednisolone
- dione
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ABUISBDTYAZRHY-RBKZJGKHSA-N (6s,8s,9r,10s,11s,13s,14s,17r)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3C[C@H](F)C2=C1 ABUISBDTYAZRHY-RBKZJGKHSA-N 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 6
- 238000005886 esterification reaction Methods 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- BCFCRXOJOFDUMZ-ONKRVSLGSA-N Anecortave Chemical compound O=C1CC[C@]2(C)C3=CC[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 BCFCRXOJOFDUMZ-ONKRVSLGSA-N 0.000 abstract 2
- 230000032050 esterification Effects 0.000 abstract 2
- 150000002905 orthoesters Chemical class 0.000 abstract 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000006356 dehydrogenation reaction Methods 0.000 abstract 1
- 238000003682 fluorination reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- CUILPNURFADTPE-UHFFFAOYSA-N hypobromous acid Chemical compound BrO CUILPNURFADTPE-UHFFFAOYSA-N 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 235000011056 potassium acetate Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cleaning By Liquid Or Steam (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1727667 | 1967-06-16 | ||
| IT1727767 | 1967-06-16 | ||
| IT1727367 | 1967-06-16 | ||
| IT1727567 | 1967-06-16 | ||
| IT1727467 | 1967-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1202001A true GB1202001A (en) | 1970-08-12 |
Family
ID=27517779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2817668A Expired GB1202001A (en) | 1967-06-16 | 1968-06-13 | 6alpha,9alpha-DIFLUOROPREDNISOLONE 17,21-DIESTERS |
Country Status (8)
| Country | Link |
|---|---|
| CH (2) | CH553760A (enrdf_load_stackoverflow) |
| DE (1) | DE1768673B1 (enrdf_load_stackoverflow) |
| DK (1) | DK131994C (enrdf_load_stackoverflow) |
| FI (1) | FI45657C (enrdf_load_stackoverflow) |
| FR (1) | FR8195M (enrdf_load_stackoverflow) |
| GB (1) | GB1202001A (enrdf_load_stackoverflow) |
| NO (1) | NO129569B (enrdf_load_stackoverflow) |
| SE (1) | SE339685B (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2421914A1 (fr) * | 1978-04-05 | 1979-11-02 | Prochem Ets | 3-acetoxy-9b-11b-epoxy-pregna-trienes et dienes et procede de preparation de 6a-halogeno-pregna-1,4-diene-3 ones et de 6a halogeno-pregna-4-ene-3-ones correspondants |
| EP0030615A1 (en) * | 1979-11-16 | 1981-06-24 | STEROSYNT Ltd. | 6-Alpha-9-alpha-difluoro-16-beta-methyl-prednisolone-17,21 diesters and pharmaceutical compositions containing them |
-
1968
- 1968-06-12 SE SE790768A patent/SE339685B/xx unknown
- 1968-06-13 GB GB2817668A patent/GB1202001A/en not_active Expired
- 1968-06-14 DE DE19681768673 patent/DE1768673B1/de active Pending
- 1968-06-14 FR FR155140A patent/FR8195M/fr not_active Expired
- 1968-06-14 DK DK282468A patent/DK131994C/da active
- 1968-06-15 NO NO233768A patent/NO129569B/no unknown
- 1968-06-17 CH CH13871A patent/CH553760A/xx not_active IP Right Cessation
- 1968-06-17 CH CH897968A patent/CH551396A/xx not_active IP Right Cessation
- 1968-06-17 FI FI168768A patent/FI45657C/fi active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2421914A1 (fr) * | 1978-04-05 | 1979-11-02 | Prochem Ets | 3-acetoxy-9b-11b-epoxy-pregna-trienes et dienes et procede de preparation de 6a-halogeno-pregna-1,4-diene-3 ones et de 6a halogeno-pregna-4-ene-3-ones correspondants |
| EP0030615A1 (en) * | 1979-11-16 | 1981-06-24 | STEROSYNT Ltd. | 6-Alpha-9-alpha-difluoro-16-beta-methyl-prednisolone-17,21 diesters and pharmaceutical compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| DK131994C (da) | 1976-03-01 |
| CH553760A (de) | 1974-09-13 |
| DE1768673B1 (de) | 1971-10-14 |
| FI45657C (fi) | 1972-08-10 |
| FR8195M (enrdf_load_stackoverflow) | 1970-09-14 |
| DK131994B (da) | 1975-10-06 |
| CH551396A (de) | 1974-07-15 |
| SE339685B (enrdf_load_stackoverflow) | 1971-10-18 |
| NO129569B (enrdf_load_stackoverflow) | 1974-04-29 |
| FI45657B (enrdf_load_stackoverflow) | 1972-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |