GB1195932A - Quinazolinylureas - Google Patents
QuinazolinylureasInfo
- Publication number
- GB1195932A GB1195932A GB22133/68A GB2213368A GB1195932A GB 1195932 A GB1195932 A GB 1195932A GB 22133/68 A GB22133/68 A GB 22133/68A GB 2213368 A GB2213368 A GB 2213368A GB 1195932 A GB1195932 A GB 1195932A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- alkyl
- nco
- chloro
- quinazolinylureas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 2-furfuryl Chemical group 0.000 abstract 15
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 2
- 239000011707 mineral Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- RVZHUQPIBHMAEX-UHFFFAOYSA-N sodium;isocyanate Chemical compound [Na+].[N-]=C=O RVZHUQPIBHMAEX-UHFFFAOYSA-N 0.000 abstract 2
- MECYPSZRPABYIV-UHFFFAOYSA-N (2-chloroquinazolin-4-yl)urea Chemical compound C1=CC=C2C(NC(=O)N)=NC(Cl)=NC2=C1 MECYPSZRPABYIV-UHFFFAOYSA-N 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
- YPNGRZOYTLZRBD-UHFFFAOYSA-N 2-chloroquinazolin-4-amine Chemical class C1=CC=C2C(N)=NC(Cl)=NC2=C1 YPNGRZOYTLZRBD-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000006331 halo benzoyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- DRYRBWIFRVMRPV-UHFFFAOYSA-N quinazolin-4-amine Chemical class C1=CC=C2C(N)=NC=NC2=C1 DRYRBWIFRVMRPV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70253468A | 1968-02-02 | 1968-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1195932A true GB1195932A (en) | 1970-06-24 |
Family
ID=24821601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22133/68A Expired GB1195932A (en) | 1968-02-02 | 1968-05-09 | Quinazolinylureas |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3574212A (enrdf_load_stackoverflow) |
| BE (1) | BE726984A (enrdf_load_stackoverflow) |
| DE (1) | DE1901519A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2001171A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1195932A (enrdf_load_stackoverflow) |
| SE (1) | SE358166B (enrdf_load_stackoverflow) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3723434A (en) * | 1970-07-17 | 1973-03-27 | Pfizer | Piperazino isoquinoline bronchodilators |
| US3980650A (en) * | 1972-05-05 | 1976-09-14 | N.V. Koninklijke Pharmaceutische Fabrieken V/H Brocades-Stheeman En Pharmacia | 4-Amino-pyrimidine derivatives |
| JPS536156B2 (enrdf_load_stackoverflow) * | 1972-10-30 | 1978-03-04 | ||
| JPS5793977A (en) * | 1980-11-26 | 1982-06-11 | Sankyo Co Ltd | Acylaminoquinazoline derivative and its preparation |
| CS236097B1 (en) * | 1983-06-01 | 1985-05-15 | Jan Koenig | Acylderivatives of 2-piperazinochinazoline and method of their preparation |
| JPS62212385A (ja) * | 1986-03-13 | 1987-09-18 | Kotobuki Seiyaku Kk | キナゾリン誘導体並びに血圧降下剤及びその製法 |
| US5932538A (en) * | 1996-02-02 | 1999-08-03 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
| US20050065161A1 (en) * | 1996-02-02 | 2005-03-24 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
| US20020143007A1 (en) * | 1996-02-02 | 2002-10-03 | Garvey David S. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use |
-
1968
- 1968-02-02 US US702534A patent/US3574212A/en not_active Expired - Lifetime
- 1968-05-09 GB GB22133/68A patent/GB1195932A/en not_active Expired
- 1968-12-31 SE SE18055/68A patent/SE358166B/xx unknown
-
1969
- 1969-01-14 DE DE19691901519 patent/DE1901519A1/de active Pending
- 1969-01-16 FR FR6900654A patent/FR2001171A1/fr not_active Withdrawn
- 1969-01-16 BE BE726984D patent/BE726984A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE358166B (enrdf_load_stackoverflow) | 1973-07-23 |
| DE1901519A1 (de) | 1969-08-28 |
| US3574212A (en) | 1971-04-06 |
| FR2001171A1 (enrdf_load_stackoverflow) | 1969-09-26 |
| BE726984A (enrdf_load_stackoverflow) | 1969-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |