GB1195491A - 4-Substituted 7- and 8-Chloroquinolines, the Preparation thereof, and Compositions Containing the same - Google Patents
4-Substituted 7- and 8-Chloroquinolines, the Preparation thereof, and Compositions Containing the sameInfo
- Publication number
- GB1195491A GB1195491A GB17091/68A GB1709168A GB1195491A GB 1195491 A GB1195491 A GB 1195491A GB 17091/68 A GB17091/68 A GB 17091/68A GB 1709168 A GB1709168 A GB 1709168A GB 1195491 A GB1195491 A GB 1195491A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chloroquinoline
- group
- alkyl
- general formula
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000005666 8-chloroquinolines Chemical class 0.000 title abstract 4
- 150000005663 7-chloroquinolines Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 4
- 238000006243 chemical reaction Methods 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- -1 alkali metal salt Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 231100000252 nontoxic Toxicity 0.000 abstract 3
- 230000003000 nontoxic effect Effects 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- RUSMDMDNFUYZTM-UHFFFAOYSA-N 8-chloroquinoline Chemical compound C1=CN=C2C(Cl)=CC=CC2=C1 RUSMDMDNFUYZTM-UHFFFAOYSA-N 0.000 abstract 2
- 150000001340 alkali metals Chemical class 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR102441A FR6198M (en:Method) | 1967-04-12 | 1967-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1195491A true GB1195491A (en) | 1970-06-17 |
Family
ID=8628702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB17091/68A Expired GB1195491A (en) | 1967-04-12 | 1968-04-09 | 4-Substituted 7- and 8-Chloroquinolines, the Preparation thereof, and Compositions Containing the same |
Country Status (11)
| Country | Link |
|---|---|
| BE (1) | BE713064A (en:Method) |
| CH (1) | CH489499A (en:Method) |
| DE (1) | DE1770187C3 (en:Method) |
| DK (1) | DK120338B (en:Method) |
| ES (1) | ES352632A1 (en:Method) |
| FR (1) | FR6198M (en:Method) |
| GB (1) | GB1195491A (en:Method) |
| IL (1) | IL29660A (en:Method) |
| NL (1) | NL6805173A (en:Method) |
| OA (1) | OA03359A (en:Method) |
| SE (1) | SE326961B (en:Method) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7618975B2 (en) | 2003-07-03 | 2009-11-17 | Myriad Pharmaceuticals, Inc. | 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US7989462B2 (en) | 2003-07-03 | 2011-08-02 | Myrexis, Inc. | 4-arylamin-or-4-heteroarylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
-
1967
- 1967-04-12 FR FR102441A patent/FR6198M/fr not_active Expired
-
1968
- 1968-03-19 IL IL29660A patent/IL29660A/xx unknown
- 1968-04-01 BE BE713064D patent/BE713064A/xx unknown
- 1968-04-01 CH CH478768A patent/CH489499A/fr not_active IP Right Cessation
- 1968-04-09 GB GB17091/68A patent/GB1195491A/en not_active Expired
- 1968-04-10 OA OA53247A patent/OA03359A/xx unknown
- 1968-04-10 ES ES352632A patent/ES352632A1/es not_active Expired
- 1968-04-10 DK DK160868AA patent/DK120338B/da unknown
- 1968-04-10 SE SE04830/68A patent/SE326961B/xx unknown
- 1968-04-11 NL NL6805173A patent/NL6805173A/xx unknown
- 1968-04-11 DE DE1770187A patent/DE1770187C3/de not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7618975B2 (en) | 2003-07-03 | 2009-11-17 | Myriad Pharmaceuticals, Inc. | 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US7989462B2 (en) | 2003-07-03 | 2011-08-02 | Myrexis, Inc. | 4-arylamin-or-4-heteroarylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| OA03359A (fr) | 1970-12-15 |
| IL29660A (en) | 1971-02-25 |
| DE1770187B2 (de) | 1978-02-23 |
| CH489499A (fr) | 1970-04-30 |
| DK120338B (da) | 1971-05-17 |
| SE326961B (en:Method) | 1970-08-10 |
| FR6198M (en:Method) | 1968-07-22 |
| ES352632A1 (es) | 1969-07-16 |
| DE1770187C3 (de) | 1978-10-05 |
| NL6805173A (en:Method) | 1968-10-14 |
| BE713064A (en:Method) | 1968-10-01 |
| DE1770187A1 (de) | 1971-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |