GB1194280A - Phenylcyclohexene Carboxylic Acid and Esters and a method for preparing the same - Google Patents
Phenylcyclohexene Carboxylic Acid and Esters and a method for preparing the sameInfo
- Publication number
- GB1194280A GB1194280A GB47358/68A GB4735868A GB1194280A GB 1194280 A GB1194280 A GB 1194280A GB 47358/68 A GB47358/68 A GB 47358/68A GB 4735868 A GB4735868 A GB 4735868A GB 1194280 A GB1194280 A GB 1194280A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carboxylic acid
- phenylcyclohexene
- esters
- diethylamino
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,194,280. 2 - Phenyl - cyclohexene - 3 - carboxylic acid and derivatives. LABORATORIO GUIDOTTE & C. S.p.A. 7 Oct., 1968 [7 Oct., 1967], No. 47358/68. Heading C2C. Novel compounds of Formula (I) and acid addition and quaternary salts of those which are basic, wherein R is H, dimethylaminoethyl, diethylaminoethyl, diethylaminoethoxyethyl, 1 - methyl - 2 - (diethylamino) ethyl, 2,2 - dimethyl - 3 - (diethylamino) - propyl, 2,2- dimethyl - 3 - morpholinopropyl, tropyl, N- methylpiperidin - 3 - yl or a radical of formula are prepared by one of the following methods: (a) when R is H, by dehydration of the corresponding 2 - hydroxy - 2 - phenyl - cyclohexane - 1 - carboxylic acid, (b) by reaction of the acid chloride derived from the compound R = H with the appropriate alcohol or potassium salt thereof, (c) by reaction of the compound where R is Na or K with the appropriate aminoalkyl halide, or (d) by transesterification. The novel compounds have therapeutic activity as antispastic and antiulcer agents.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2136767 | 1967-10-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1194280A true GB1194280A (en) | 1970-06-10 |
Family
ID=11180736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB47358/68A Expired GB1194280A (en) | 1967-10-07 | 1968-10-07 | Phenylcyclohexene Carboxylic Acid and Esters and a method for preparing the same |
Country Status (12)
Country | Link |
---|---|
AT (1) | AT289751B (en) |
BE (1) | BE721948A (en) |
BR (1) | BR6802854D0 (en) |
CH (1) | CH533082A (en) |
DE (1) | DE1800974B2 (en) |
DK (1) | DK133373B (en) |
ES (1) | ES358926A1 (en) |
FR (1) | FR8246M (en) |
GB (1) | GB1194280A (en) |
IL (1) | IL30816A (en) |
NL (1) | NL161132C (en) |
SE (1) | SE356973B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4229207A (en) * | 1975-08-15 | 1980-10-21 | Ciba-Geigy Corporation | Esters of 1,2-diphenyl-cyclohex-1-ene-4-carboxylic acid |
IT1213033B (en) * | 1986-02-11 | 1989-12-07 | Guidotti & C Spa Labor | ESTERS OF N-ALCHIL-NORTROPINE ELORO AMMONIOQUATERNARY DERIVATIVES WITH ANTI-BRONCHOSPASTIC ACTIVITIES, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT. |
-
1968
- 1968-10-03 CH CH1476868A patent/CH533082A/en not_active IP Right Cessation
- 1968-10-03 DE DE19681800974 patent/DE1800974B2/en active Granted
- 1968-10-03 IL IL30816A patent/IL30816A/en unknown
- 1968-10-04 BR BR202854/68A patent/BR6802854D0/en unknown
- 1968-10-04 FR FR42000198A patent/FR8246M/fr not_active Expired
- 1968-10-04 SE SE13423/68A patent/SE356973B/xx unknown
- 1968-10-07 NL NL6814330.A patent/NL161132C/en not_active IP Right Cessation
- 1968-10-07 DK DK482068AA patent/DK133373B/en unknown
- 1968-10-07 GB GB47358/68A patent/GB1194280A/en not_active Expired
- 1968-10-07 ES ES358926A patent/ES358926A1/en not_active Expired
- 1968-10-07 BE BE721948A patent/BE721948A/xx unknown
- 1968-10-07 AT AT09793/68A patent/AT289751B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE1800974C3 (en) | 1973-09-13 |
SE356973B (en) | 1973-06-12 |
NL6814330A (en) | 1969-04-09 |
DE1800974A1 (en) | 1969-06-04 |
NL161132C (en) | 1980-01-15 |
BE721948A (en) | 1969-03-14 |
AT289751B (en) | 1971-03-15 |
IL30816A0 (en) | 1968-12-26 |
NL161132B (en) | 1979-08-15 |
DK133373C (en) | 1976-10-11 |
CH533082A (en) | 1973-01-31 |
BR6802854D0 (en) | 1973-02-22 |
FR8246M (en) | 1970-10-12 |
ES358926A1 (en) | 1970-05-16 |
DK133373B (en) | 1976-05-10 |
IL30816A (en) | 1973-04-30 |
DE1800974B2 (en) | 1973-01-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |