GB1184396A - New Morpholine Derivatives, Process for their Production and Compositions containing them - Google Patents
New Morpholine Derivatives, Process for their Production and Compositions containing themInfo
- Publication number
- GB1184396A GB1184396A GB1192368A GB1192368A GB1184396A GB 1184396 A GB1184396 A GB 1184396A GB 1192368 A GB1192368 A GB 1192368A GB 1192368 A GB1192368 A GB 1192368A GB 1184396 A GB1184396 A GB 1184396A
- Authority
- GB
- United Kingdom
- Prior art keywords
- morpholine
- benzyl
- methylenedioxyphenyl
- methylenedioxy
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002780 morpholines Chemical class 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title 1
- -1 polymethyleneimino group Polymers 0.000 abstract 8
- WVDDGKGOMKODPV-UHFFFAOYSA-N hydroxymethyl benzene Natural products OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- GZGXWSZGKAWATN-UHFFFAOYSA-N 2-(2,2-diethoxyethyl)oxirane Chemical compound CCOC(OCC)CC1CO1 GZGXWSZGKAWATN-UHFFFAOYSA-N 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 150000001241 acetals Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 235000019445 benzyl alcohol Nutrition 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 238000004809 thin layer chromatography Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH370767A CH480360A (de) | 1967-03-13 | 1967-03-13 | Verfahren zur Herstellung von neuen Morpholinderivaten |
| CH1286867 | 1967-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1184396A true GB1184396A (en) | 1970-03-18 |
Family
ID=25693667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1192368A Expired GB1184396A (en) | 1967-03-13 | 1968-03-12 | New Morpholine Derivatives, Process for their Production and Compositions containing them |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT274828B (forum.php) |
| BE (1) | BE712057A (forum.php) |
| CH (1) | CH480360A (forum.php) |
| DE (1) | DE1695127A1 (forum.php) |
| ES (1) | ES351511A1 (forum.php) |
| FR (1) | FR1555439A (forum.php) |
| GB (1) | GB1184396A (forum.php) |
| IE (1) | IE31982B1 (forum.php) |
| NL (1) | NL6803508A (forum.php) |
| SE (1) | SE342046B (forum.php) |
-
1967
- 1967-03-13 CH CH370767A patent/CH480360A/de not_active IP Right Cessation
-
1968
- 1968-03-12 IE IE28868A patent/IE31982B1/xx unknown
- 1968-03-12 AT AT242768A patent/AT274828B/de active
- 1968-03-12 FR FR1555439D patent/FR1555439A/fr not_active Expired
- 1968-03-12 NL NL6803508A patent/NL6803508A/xx unknown
- 1968-03-12 DE DE19681695127 patent/DE1695127A1/de active Pending
- 1968-03-12 GB GB1192368A patent/GB1184396A/en not_active Expired
- 1968-03-12 ES ES351511A patent/ES351511A1/es not_active Expired
- 1968-03-12 SE SE324768A patent/SE342046B/xx unknown
- 1968-03-12 BE BE712057D patent/BE712057A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE31982L (en) | 1968-09-13 |
| BE712057A (forum.php) | 1968-09-12 |
| NL6803508A (forum.php) | 1968-09-16 |
| SE342046B (forum.php) | 1972-01-24 |
| AT274828B (de) | 1969-10-10 |
| ES351511A1 (es) | 1969-06-01 |
| DE1695127A1 (de) | 1971-04-08 |
| CH480360A (de) | 1969-10-31 |
| FR1555439A (forum.php) | 1969-01-24 |
| IE31982B1 (en) | 1973-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1423822A (en) | Processes for the production of optically active esters of a-amino acids | |
| GB1433817A (en) | N-heteroarylmethyl-benzomorphane derivatives | |
| US4151357A (en) | Polyprenyl piperazines | |
| GB1301224A (forum.php) | ||
| GB1466724A (en) | Thiaprostaglandins process for their manufacture and pharmaceu tical preparations containing them | |
| GB1285400A (en) | Esters of substituted anthranilic acid | |
| GB1184396A (en) | New Morpholine Derivatives, Process for their Production and Compositions containing them | |
| US3203962A (en) | Alpha-phenyl-beta pyrrolidino-propiophenones | |
| GB1496491A (en) | Dihydroergopeptine derivatives | |
| DE3483881D1 (de) | 1,3-dioxan-4-ylalkensaeure. | |
| US3252996A (en) | Alpha-pyrrolidinomethyl valero and caprophenones | |
| GB532822A (en) | Improvements in and relating to the production of ª‡-coumarilyl and ª‡-thionaphthenoyl-acetic acid esters | |
| ES421098A1 (es) | Un metodo para la preparacion de tiaxantenos fluor-susti- tuidos. | |
| GB1361863A (en) | Piperazine derivatives their preparation and pharmaceutical compositions containing them | |
| ES361113A1 (es) | Un procedimiento para la preparacion de compuestos anti-fi-brinoliticos. | |
| GB1185987A (en) | Morpholine Derivatives and Process for their Production | |
| GB1126860A (en) | Novel 4-substituted-7- and 8-chloroquinolines and a process for the preparation thereof | |
| GB1428933A (en) | 5-phenyl-sulphinyl-2-benzimidazolyl-carbamic acid esters and process for their manufacture | |
| GB1179900A (en) | Tropic acid derivatives | |
| GB1348258A (en) | 9-oxo-6.9-dihydro-4h-dioxino-4,5-g-quinolyl-8-carboxylic acids and their isomers, 10-oxo-7,10-dihydro-1h-dioxino-5,4-f-quinolyl- 9-carboxylic acids | |
| ES348973A1 (es) | Un procedimiento de preparacion del (dioxido-2,5 pirrolidi-no-i)-i (perhidroazepino-i)-4 butino-2. | |
| GB798847A (en) | Novel quinolizine derivatives and a process for the manufacture thereof | |
| GB1451043A (en) | Biologicylly acitve compounds and compositions | |
| GB1392671A (en) | Salts of an ester of 3-thienyl-cyclohexyl-acetic acid and their preparation and use | |
| GB1187733A (en) | 0,3,10-Berbine Derivatives, their Acid Addition Salts, and Process for the Preparation Thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |