GB1179019A - Polynicotinic Esters of Flavonoids - Google Patents

Polynicotinic Esters of Flavonoids

Info

Publication number
GB1179019A
GB1179019A GB21078/67A GB2107867A GB1179019A GB 1179019 A GB1179019 A GB 1179019A GB 21078/67 A GB21078/67 A GB 21078/67A GB 2107867 A GB2107867 A GB 2107867A GB 1179019 A GB1179019 A GB 1179019A
Authority
GB
United Kingdom
Prior art keywords
polynicotinic
flavonoids
esters
pyridine
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB21078/67A
Other languages
English (en)
Inventor
Eugene L Leroi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PRODUITS CHIMIQUE SOC ET
Original Assignee
PRODUITS CHIMIQUE SOC ET
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PRODUITS CHIMIQUE SOC ET filed Critical PRODUITS CHIMIQUE SOC ET
Priority to GB21078/67A priority Critical patent/GB1179019A/en
Priority to BE714423D priority patent/BE714423A/xx
Priority to CH644668A priority patent/CH478143A/fr
Priority to FR1561764D priority patent/FR1561764A/fr
Priority to NL6806337A priority patent/NL132132C/xx
Priority to DE19681770324 priority patent/DE1770324C3/de
Priority to ES353537A priority patent/ES353537A1/es
Priority to FR160341A priority patent/FR7941M/fr
Publication of GB1179019A publication Critical patent/GB1179019A/en
Priority to US00055620A priority patent/US3751570A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB21078/67A 1967-05-05 1967-05-23 Polynicotinic Esters of Flavonoids Expired GB1179019A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GB21078/67A GB1179019A (en) 1967-05-23 1967-05-23 Polynicotinic Esters of Flavonoids
BE714423D BE714423A (enExample) 1967-05-23 1968-04-29
CH644668A CH478143A (fr) 1967-05-23 1968-04-30 Procédé pour la préparation de nouveaux esters polynicotiniques
FR1561764D FR1561764A (enExample) 1967-05-23 1968-04-30
NL6806337A NL132132C (enExample) 1967-05-23 1968-05-03
DE19681770324 DE1770324C3 (de) 1967-05-05 1968-05-03 Polynicotinsäureester von Flavonolden, Verfahren zu ihrer Herstellung und solche Verbindungen enthaltende therapeutische Zusammensetzung
ES353537A ES353537A1 (es) 1967-05-23 1968-05-04 Un procedimiento de preparacion de esteres polinicotinicos de flavonoides.
FR160341A FR7941M (enExample) 1967-05-23 1968-07-24
US00055620A US3751570A (en) 1967-05-23 1970-07-16 Polynicotinic esters of hesperidin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB21078/67A GB1179019A (en) 1967-05-23 1967-05-23 Polynicotinic Esters of Flavonoids

Publications (1)

Publication Number Publication Date
GB1179019A true GB1179019A (en) 1970-01-28

Family

ID=10156835

Family Applications (1)

Application Number Title Priority Date Filing Date
GB21078/67A Expired GB1179019A (en) 1967-05-05 1967-05-23 Polynicotinic Esters of Flavonoids

Country Status (7)

Country Link
US (1) US3751570A (enExample)
BE (1) BE714423A (enExample)
CH (1) CH478143A (enExample)
ES (1) ES353537A1 (enExample)
FR (2) FR1561764A (enExample)
GB (1) GB1179019A (enExample)
NL (1) NL132132C (enExample)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0420232A3 (en) * 1989-09-28 1991-12-04 European Pharmacy Srl Water soluble derivatives of glycoside bioflavonoids, processes for their preparation and related pharmaceutical compositions
US5877208A (en) * 1996-10-14 1999-03-02 Korea Institute Of Science And Technology Naringin and naringenin as 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase inhibitor
WO2006045096A3 (en) * 2004-10-20 2007-08-02 Resverlogix Corp Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
US8053440B2 (en) 2007-02-01 2011-11-08 Resverlogix Corporation Compounds for the prevention and treatment of cardiovascular diseases
US8114995B2 (en) 2008-06-26 2012-02-14 Resverlogix Corp. Methods of preparing quinazolinone derivatives
US8410109B2 (en) 2005-07-29 2013-04-02 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US8952021B2 (en) 2009-01-08 2015-02-10 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9238640B2 (en) 2009-03-18 2016-01-19 Resverlogix Corp. Anti-inflammatory agents
US9271978B2 (en) 2012-12-21 2016-03-01 Zenith Epigenetics Corp. Heterocyclic compounds as bromodomain inhibitors
US9610251B2 (en) 2011-11-01 2017-04-04 Resverlogix Corp. Pharmaceutical compositions for substituted quinazolinones
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
US10111885B2 (en) 2015-03-13 2018-10-30 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH602778A5 (enExample) * 1975-05-16 1978-07-31 Hommel Ag
GB1575004A (en) * 1976-03-23 1980-09-17 Iverni Della Beffa Spa Pharmacologically active polyphenolic substances
WO1998011876A1 (de) * 1996-09-18 1998-03-26 Marigen S.A. Bioflavonol-glykosid-perester und ihre aufarbeitung zu pharmakologisch wirksamen konzentraten und ultramikroemulsionen
AUPR255401A0 (en) * 2001-01-16 2001-02-08 Novogen Research Pty Ltd Regulation of lipids and/or bone density and compositions therefor

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0420232A3 (en) * 1989-09-28 1991-12-04 European Pharmacy Srl Water soluble derivatives of glycoside bioflavonoids, processes for their preparation and related pharmaceutical compositions
US5877208A (en) * 1996-10-14 1999-03-02 Korea Institute Of Science And Technology Naringin and naringenin as 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase inhibitor
US8242130B2 (en) 2004-10-20 2012-08-14 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
WO2006045096A3 (en) * 2004-10-20 2007-08-02 Resverlogix Corp Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
US7846915B2 (en) 2004-10-20 2010-12-07 Resverlogix Corporation Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
EP2332527A3 (en) * 2004-10-20 2011-11-16 Resverlogix Corp. Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases
US8093273B2 (en) 2004-10-20 2012-01-10 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
US8410109B2 (en) 2005-07-29 2013-04-02 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US8053440B2 (en) 2007-02-01 2011-11-08 Resverlogix Corporation Compounds for the prevention and treatment of cardiovascular diseases
US8889698B2 (en) 2007-02-01 2014-11-18 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular diseases
US9199990B2 (en) 2007-02-01 2015-12-01 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular diseases
US10532054B2 (en) 2007-02-01 2020-01-14 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular diseases
US8114995B2 (en) 2008-06-26 2012-02-14 Resverlogix Corp. Methods of preparing quinazolinone derivatives
US8952021B2 (en) 2009-01-08 2015-02-10 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
US11407719B2 (en) 2009-03-18 2022-08-09 Resverlogix Corp. Anti-inflammatory agents
US9238640B2 (en) 2009-03-18 2016-01-19 Resverlogix Corp. Anti-inflammatory agents
US10882828B2 (en) 2009-03-18 2021-01-05 Resverlogix Corp. Anti-inflammatory agents
US10131640B2 (en) 2009-03-18 2018-11-20 Resverlogix Corp. Anti-inflammatory agents
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
US10016426B2 (en) 2011-11-01 2018-07-10 Resverlogix Corp. Pharmaceutical compositions for substituted quinazolinones
US9610251B2 (en) 2011-11-01 2017-04-04 Resverlogix Corp. Pharmaceutical compositions for substituted quinazolinones
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
US9278940B2 (en) 2012-11-21 2016-03-08 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9271978B2 (en) 2012-12-21 2016-03-01 Zenith Epigenetics Corp. Heterocyclic compounds as bromodomain inhibitors
US10111885B2 (en) 2015-03-13 2018-10-30 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
US10772894B2 (en) 2015-03-13 2020-09-15 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases

Also Published As

Publication number Publication date
CH478143A (fr) 1969-09-15
FR7941M (enExample) 1970-05-25
DE1770324B2 (de) 1976-07-22
NL132132C (enExample) 1971-03-15
US3751570A (en) 1973-08-07
BE714423A (enExample) 1968-09-16
FR1561764A (enExample) 1969-03-28
NL6806337A (enExample) 1968-11-06
ES353537A1 (es) 1969-10-01
DE1770324A1 (de) 1972-04-20

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee