GB1176501A - Leucomycins A3 to A9 - Google Patents
Leucomycins A3 to A9Info
- Publication number
- GB1176501A GB1176501A GB4004667A GB4004667A GB1176501A GB 1176501 A GB1176501 A GB 1176501A GB 4004667 A GB4004667 A GB 4004667A GB 4004667 A GB4004667 A GB 4004667A GB 1176501 A GB1176501 A GB 1176501A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzene
- leucomycin
- sept
- chloroform
- acetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,176,501. Leucomycins A3 to A9. KITASATO INSTITUTE and TOYO JOZO K.K. 1 Sept., 1967 [5 Sept., 1966 (4); 21 Sept., 1966 (2); 25 Feb., 1967 (2)], No. 40046/67. Heading C2A. Leuconycin components A 3 to A 9 are produced by cultivating a leucomycin-producing strain of streptomyces kitasatoensis e.g. NRRL 2486 and 2487 in an aqueous nutrient medium. The crude leucomycin is extracted from the clarified broth at pH 7À5 to 9 with a waterimmiscible organic solvent such as benzene or butyl acetate, treated with an aqueous acid (e.g. aqueous hydrochloric acid) of pH 2 to 4 and re-extracted with a water-immiscible organic solvent (e.g. benzene) at pH 7À5 to 9À0. The extract is concentrated and crude leucomycin recovered by (a) addition of petroleum ether, (b) pyophilization or (c) adjustment to pH 7À0 to 9À0. The leucomycin components A 3 to A 9 are separated by (a) chromatographic adsorption on silica gel or activated alumina and developed with benzene/acetone or benzene/methanol solvent systems, and (b) countercurrent distribution using benzene/chloroform/ methanol/citric acid buffer of pH 4À9 (20 : 6 : 20 : 8). The mixture of leucomycin antibiotics A 3 to A 9 is a white powder; mpt. 128-145‹ C., containing C = 60À00%, H = 8À80%, N = 1À68%; U.V. spectrum max. at 231 mÁ with 1% E = 353; mol. wt. 800, α] D <SP>25</SP> = - 53 degrees 1cm. (1% in chloroform); soluble in methanol, ethanol, ethyl acetate, butyl acetate, acetone, methyl ethyl ketone, benzene and chloroform; difficulty soluble in water; insoluble in petroleum ether. The antibiotics form salts with acids. They have the formula wherein R 1 is hydrogen and R 2 is acetyl (A9) or propionyl (A7) or butyryl (A5); or wherein R 1 is acetyl and R 2 is acetyl (A8) or propionyl (A6) or butyryl (A4) or isovaleryl (A3).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4004667A GB1176501A (en) | 1967-09-01 | 1967-09-01 | Leucomycins A3 to A9 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4004667A GB1176501A (en) | 1967-09-01 | 1967-09-01 | Leucomycins A3 to A9 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1176501A true GB1176501A (en) | 1970-01-07 |
Family
ID=10412902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4004667A Expired GB1176501A (en) | 1967-09-01 | 1967-09-01 | Leucomycins A3 to A9 |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1176501A (en) |
-
1967
- 1967-09-01 GB GB4004667A patent/GB1176501A/en not_active Expired
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