GB1173227A - Amino-Isoquinolines - Google Patents
Amino-IsoquinolinesInfo
- Publication number
- GB1173227A GB1173227A GB2895167A GB2895167A GB1173227A GB 1173227 A GB1173227 A GB 1173227A GB 2895167 A GB2895167 A GB 2895167A GB 2895167 A GB2895167 A GB 2895167A GB 1173227 A GB1173227 A GB 1173227A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- general formula
- amino
- group
- quaternary ammonium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OSILBMSORKFRTB-UHFFFAOYSA-N isoquinolin-1-amine Chemical class C1=CC=C2C(N)=NC=CC2=C1 OSILBMSORKFRTB-UHFFFAOYSA-N 0.000 title abstract 4
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- BQIKRTGTPBOIMK-UHFFFAOYSA-N [O]C[O] Chemical compound [O]C[O] BQIKRTGTPBOIMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003001 depressive effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR166799A FR7723M (en:Method) | 1967-06-22 | 1967-06-22 | |
| GB2895167A GB1173227A (en) | 1967-06-22 | 1967-06-22 | Amino-Isoquinolines |
| BE716821D BE716821A (en:Method) | 1967-06-22 | 1968-06-19 | |
| DE19681770670 DE1770670A1 (de) | 1967-06-22 | 1968-06-20 | Verfahren zur Herstellung von 1-Aminoisochinolinverbindungen |
| FR1579053D FR1579053A (en:Method) | 1967-06-22 | 1968-06-20 | |
| NL6808726A NL6808726A (en:Method) | 1967-06-22 | 1968-06-21 | |
| CH932568A CH500983A (de) | 1967-06-22 | 1968-06-21 | Verfahren zur Herstellung von 1-Amino-isochinolinen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2895167A GB1173227A (en) | 1967-06-22 | 1967-06-22 | Amino-Isoquinolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1173227A true GB1173227A (en) | 1969-12-03 |
Family
ID=10283841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2895167A Expired GB1173227A (en) | 1967-06-22 | 1967-06-22 | Amino-Isoquinolines |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE716821A (en:Method) |
| CH (1) | CH500983A (en:Method) |
| DE (1) | DE1770670A1 (en:Method) |
| FR (2) | FR7723M (en:Method) |
| GB (1) | GB1173227A (en:Method) |
| NL (1) | NL6808726A (en:Method) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3991063A (en) * | 1971-09-09 | 1976-11-09 | Wijbe Thomas Nauta | Aminoisoquinolines |
| US6635642B1 (en) | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
| WO1999011622A1 (en) * | 1997-09-03 | 1999-03-11 | Guilford Pharmaceuticals Inc. | Amino-substituted compounds, methods, and compositions for inhibiting parp activity |
| US6291425B1 (en) | 1999-09-01 | 2001-09-18 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage |
| US6426415B1 (en) | 1997-09-03 | 2002-07-30 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity |
| US6514983B1 (en) | 1997-09-03 | 2003-02-04 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage |
| US6346536B1 (en) | 1997-09-03 | 2002-02-12 | Guilford Pharmaceuticals Inc. | Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same |
| US6197785B1 (en) | 1997-09-03 | 2001-03-06 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity |
| US6395749B1 (en) | 1998-05-15 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Carboxamide compounds, methods, and compositions for inhibiting PARP activity |
| US6387902B1 (en) | 1998-12-31 | 2002-05-14 | Guilford Pharmaceuticals, Inc. | Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP |
| AU2001264595A1 (en) | 2000-05-19 | 2001-12-03 | Guilford Pharmaceuticals Inc. | Sulfonamide and carbamide derivatives of 6(5h)phenanthridinones and their uses |
| US6348475B1 (en) | 2000-06-01 | 2002-02-19 | Guilford Pharmaceuticals Inc. | Methods, compounds and compositions for treating gout |
-
1967
- 1967-06-22 GB GB2895167A patent/GB1173227A/en not_active Expired
- 1967-06-22 FR FR166799A patent/FR7723M/fr not_active Expired
-
1968
- 1968-06-19 BE BE716821D patent/BE716821A/xx unknown
- 1968-06-20 FR FR1579053D patent/FR1579053A/fr not_active Expired
- 1968-06-20 DE DE19681770670 patent/DE1770670A1/de active Pending
- 1968-06-21 CH CH932568A patent/CH500983A/de not_active IP Right Cessation
- 1968-06-21 NL NL6808726A patent/NL6808726A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR7723M (en:Method) | 1970-03-02 |
| NL6808726A (en:Method) | 1968-12-23 |
| FR1579053A (en:Method) | 1969-08-22 |
| DE1770670A1 (de) | 1971-11-11 |
| BE716821A (en:Method) | 1968-12-19 |
| CH500983A (de) | 1970-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |