GB1173045A - Salts and Basic Antibiotics - Google Patents
Salts and Basic AntibioticsInfo
- Publication number
- GB1173045A GB1173045A GB08556/67A GB1855667A GB1173045A GB 1173045 A GB1173045 A GB 1173045A GB 08556/67 A GB08556/67 A GB 08556/67A GB 1855667 A GB1855667 A GB 1855667A GB 1173045 A GB1173045 A GB 1173045A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antibiotic
- salts
- eucalyptol
- mono
- basic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 6
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 6
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 abstract 5
- 229960005233 cineole Drugs 0.000 abstract 5
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 abstract 4
- 239000004098 Tetracycline Substances 0.000 abstract 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 abstract 2
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 2
- 229960002180 tetracycline Drugs 0.000 abstract 2
- 229930101283 tetracycline Natural products 0.000 abstract 2
- 235000019364 tetracycline Nutrition 0.000 abstract 2
- 150000003522 tetracyclines Chemical class 0.000 abstract 2
- 239000004099 Chlortetracycline Substances 0.000 abstract 1
- ASXBYYWOLISCLQ-UHFFFAOYSA-N Dihydrostreptomycin Natural products O1C(CO)C(O)C(O)C(NC)C1OC1C(CO)(O)C(C)OC1OC1C(N=C(N)N)C(O)C(N=C(N)N)C(O)C1O ASXBYYWOLISCLQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004100 Oxytetracycline Substances 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- -1 alkaline earth metal sulphate Chemical class 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229910052788 barium Inorganic materials 0.000 abstract 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 abstract 1
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 abstract 1
- 229960004475 chlortetracycline Drugs 0.000 abstract 1
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 abstract 1
- 235000019365 chlortetracycline Nutrition 0.000 abstract 1
- 229960002222 dihydrostreptomycin Drugs 0.000 abstract 1
- ASXBYYWOLISCLQ-HZYVHMACSA-N dihydrostreptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](CO)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O ASXBYYWOLISCLQ-HZYVHMACSA-N 0.000 abstract 1
- 229960003704 framycetin Drugs 0.000 abstract 1
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 abstract 1
- 229960000318 kanamycin Drugs 0.000 abstract 1
- 229930027917 kanamycin Natural products 0.000 abstract 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
- 229930182823 kanamycin A Natural products 0.000 abstract 1
- 229960000625 oxytetracycline Drugs 0.000 abstract 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 abstract 1
- 235000019366 oxytetracycline Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 229960005322 streptomycin Drugs 0.000 abstract 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
- C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08556/67A GB1173045A (en) | 1967-04-21 | 1967-04-21 | Salts and Basic Antibiotics |
| BE713442D BE713442A (https=) | 1967-04-21 | 1968-04-09 | |
| CH531968A CH472493A (fr) | 1967-04-21 | 1968-04-10 | Procédé de préparation de nouveaux sels d'antibiotiques basiques |
| OA53252A OA02795A (fr) | 1967-04-21 | 1968-04-11 | Procédé de préparation de nouveaux sels d'antibiotiques. |
| LU55896D LU55896A1 (https=) | 1967-04-21 | 1968-04-16 | |
| FI681076A FI48579C (fi) | 1967-04-21 | 1968-04-18 | Tapa valmistaa uusia eukalyptolisulfoni- ja -disulfonihapon suolo- ja emäksisten antibioottien kanssa. |
| FR148520A FR7413M (https=) | 1967-04-21 | 1968-04-18 | |
| FR1560143D FR1560143A (https=) | 1967-04-21 | 1968-04-18 | |
| NL6805565A NL6805565A (https=) | 1967-04-21 | 1968-04-19 | |
| DE19681768251 DE1768251C2 (de) | 1967-04-21 | 1968-04-19 | Antibiotika-Eukalyptolmono- und disulfonate sowie Verfahren zu ihrer Herstellung |
| DK175268AA DK127728B (da) | 1967-04-21 | 1968-04-19 | Analogifremgangsmåde til fremstilling af eucalyptolmono- eller -disulfonsyresalte af basiske antibiotika. |
| US722810A US3583973A (en) | 1967-04-21 | 1968-04-19 | Antibiotic salts of eucalyptol sulphonic acids |
| SE05269/68A SE353907B (https=) | 1967-04-21 | 1968-04-19 | |
| ES352954A ES352954A1 (es) | 1967-04-21 | 1968-04-20 | Procedimiento para preparar sales de acidos eucaliptol monoy disulfonicos de antibioticos basicos. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08556/67A GB1173045A (en) | 1967-04-21 | 1967-04-21 | Salts and Basic Antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1173045A true GB1173045A (en) | 1969-12-03 |
Family
ID=10114479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB08556/67A Expired GB1173045A (en) | 1967-04-21 | 1967-04-21 | Salts and Basic Antibiotics |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3583973A (https=) |
| BE (1) | BE713442A (https=) |
| CH (1) | CH472493A (https=) |
| DE (1) | DE1768251C2 (https=) |
| DK (1) | DK127728B (https=) |
| ES (1) | ES352954A1 (https=) |
| FI (1) | FI48579C (https=) |
| FR (2) | FR1560143A (https=) |
| GB (1) | GB1173045A (https=) |
| LU (1) | LU55896A1 (https=) |
| NL (1) | NL6805565A (https=) |
| OA (1) | OA02795A (https=) |
| SE (1) | SE353907B (https=) |
-
1967
- 1967-04-21 GB GB08556/67A patent/GB1173045A/en not_active Expired
-
1968
- 1968-04-09 BE BE713442D patent/BE713442A/xx unknown
- 1968-04-10 CH CH531968A patent/CH472493A/fr not_active IP Right Cessation
- 1968-04-11 OA OA53252A patent/OA02795A/xx unknown
- 1968-04-16 LU LU55896D patent/LU55896A1/xx unknown
- 1968-04-18 FI FI681076A patent/FI48579C/fi active
- 1968-04-18 FR FR1560143D patent/FR1560143A/fr not_active Expired
- 1968-04-18 FR FR148520A patent/FR7413M/fr not_active Expired
- 1968-04-19 DK DK175268AA patent/DK127728B/da unknown
- 1968-04-19 SE SE05269/68A patent/SE353907B/xx unknown
- 1968-04-19 US US722810A patent/US3583973A/en not_active Expired - Lifetime
- 1968-04-19 DE DE19681768251 patent/DE1768251C2/de not_active Expired
- 1968-04-19 NL NL6805565A patent/NL6805565A/xx unknown
- 1968-04-20 ES ES352954A patent/ES352954A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1768251B1 (de) | 1971-07-15 |
| FI48579B (https=) | 1974-07-31 |
| FR7413M (https=) | 1969-11-12 |
| US3583973A (en) | 1971-06-08 |
| FR1560143A (https=) | 1969-03-14 |
| DE1768251C2 (de) | 1972-01-24 |
| FI48579C (fi) | 1974-11-11 |
| NL6805565A (https=) | 1968-10-22 |
| ES352954A1 (es) | 1969-10-01 |
| BE713442A (https=) | 1968-08-16 |
| SE353907B (https=) | 1973-02-19 |
| OA02795A (fr) | 1970-12-15 |
| LU55896A1 (https=) | 1968-07-09 |
| CH472493A (fr) | 1969-05-15 |
| DK127728B (da) | 1973-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |