GB1171125A - Improvements in or relating to Injectable Preparations - Google Patents
Improvements in or relating to Injectable PreparationsInfo
- Publication number
- GB1171125A GB1171125A GB25595/66A GB2559566A GB1171125A GB 1171125 A GB1171125 A GB 1171125A GB 25595/66 A GB25595/66 A GB 25595/66A GB 2559566 A GB2559566 A GB 2559566A GB 1171125 A GB1171125 A GB 1171125A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aqueous phase
- clostriduim
- materials include
- polyoxyethylene derivative
- injectable preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- -1 fatty acid ester Chemical class 0.000 abstract 6
- 239000008346 aqueous phase Substances 0.000 abstract 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 abstract 2
- 241000588832 Bordetella pertussis Species 0.000 abstract 1
- 241000589567 Brucella abortus Species 0.000 abstract 1
- 241000206044 Clostridium chauvoei Species 0.000 abstract 1
- 241000193466 Clostridium septicum Species 0.000 abstract 1
- 241000193449 Clostridium tetani Species 0.000 abstract 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- 241000711450 Infectious bronchitis virus Species 0.000 abstract 1
- 239000005662 Paraffin oil Substances 0.000 abstract 1
- 239000011149 active material Substances 0.000 abstract 1
- 229940056450 brucella abortus Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000002191 fatty alcohols Chemical class 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 239000008206 lipophilic material Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 235000019198 oils Nutrition 0.000 abstract 1
- 229940049964 oleate Drugs 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229940032094 squalane Drugs 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- CTWLAMKOJQOQLN-UHFFFAOYSA-N tridecyl tetradecanoate Chemical compound CCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC CTWLAMKOJQOQLN-UHFFFAOYSA-N 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB25595/66A GB1171125A (en) | 1966-06-08 | 1966-06-08 | Improvements in or relating to Injectable Preparations |
US642727A US3384544A (en) | 1966-06-08 | 1967-06-01 | Injectable solutions or suspensions of antigens in optically clear colloidal solutions |
NL6707702.A NL159283B (nl) | 1966-06-08 | 1967-06-02 | Werkwijze ter bereiding van een injecteerbaar preparaat. |
IT37275/67A IT1035004B (it) | 1966-06-08 | 1967-06-06 | Composizione acquosa iniettabile e procedimento per prepararla |
DE19671617502 DE1617502C (de) | 1966-06-08 | 1967-06-08 | Injizierbare Zusammensetzungen |
BE699678D BE699678A (de) | 1966-06-08 | 1967-06-08 | |
FR119939A FR7316M (de) | 1966-06-08 | 1967-09-05 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB25595/66A GB1171125A (en) | 1966-06-08 | 1966-06-08 | Improvements in or relating to Injectable Preparations |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1171125A true GB1171125A (en) | 1969-11-19 |
Family
ID=10230237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB25595/66A Expired GB1171125A (en) | 1966-06-08 | 1966-06-08 | Improvements in or relating to Injectable Preparations |
Country Status (6)
Country | Link |
---|---|
US (1) | US3384544A (de) |
BE (1) | BE699678A (de) |
FR (1) | FR7316M (de) |
GB (1) | GB1171125A (de) |
IT (1) | IT1035004B (de) |
NL (1) | NL159283B (de) |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0059521A1 (de) * | 1981-03-03 | 1982-09-08 | Centraal Diergeneeskundig Instituut | Wasser-in-Öl-Emulsion zur Verwendung bei der Verstärkung des Immunosystems von Tieren |
EP0202837A1 (de) * | 1985-05-17 | 1986-11-26 | Smithkline Beckman Corporation | Zusammensetzung in Form einer Emulsion mit einem Gehalt von Polyenantibiotikum |
WO1992018147A1 (en) * | 1991-04-19 | 1992-10-29 | Affinity Biotech, Inc. | Convertible microemulsion formulations |
WO1994008610A1 (en) * | 1992-10-16 | 1994-04-28 | Smithkline Beecham Corporation | Pharmaceutical emulsion compositions |
WO1994017827A1 (en) * | 1993-02-15 | 1994-08-18 | Lyfjathroun H.F. | A pharmaceutical preparation for topical administration of antigens and/or vaccines to mammals via a mucosal membrane |
US5688761A (en) * | 1991-04-19 | 1997-11-18 | Lds Technologies, Inc. | Convertible microemulsion formulations |
US5741512A (en) * | 1988-09-16 | 1998-04-21 | Novartis Corporation | Pharmaceutical compositions comprising cyclosporins |
US5989566A (en) * | 1995-06-30 | 1999-11-23 | American Cyanamid Company | Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation |
US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
US6214367B1 (en) | 1996-06-05 | 2001-04-10 | Ashmont Holdings Limited | Injectable compositions |
US6245349B1 (en) | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
US6258808B1 (en) | 1991-06-27 | 2001-07-10 | Novartis Ag | Pharmaceutical composition |
US6420355B2 (en) | 1992-09-25 | 2002-07-16 | Novartis Ag | Pharmaceutical compositions containing cyclosporins |
US6475519B1 (en) | 1997-01-30 | 2002-11-05 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin A |
US6486124B2 (en) | 1994-11-03 | 2002-11-26 | Novartis Ag | Cyclosporin compositions and process therefor |
US6582718B2 (en) | 1992-05-13 | 2003-06-24 | Novartis Ag | Cyclosporin compositions |
US6951841B2 (en) | 1995-11-29 | 2005-10-04 | Novartis Ag | Pharmaceutical compositions of macrolides or cyclosporine with a polyethoxylated saturated hydroxy-fatty acid |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3678149A (en) * | 1970-01-26 | 1972-07-18 | Samuel J Prigal | Method of enhancing the action of a medicament |
AU2629871A (en) * | 1970-03-17 | 1972-09-14 | Merck & Co., Inc | Solubilization of water and aqueous solutions in non-aqueous liquids |
GB1502774A (en) * | 1974-06-25 | 1978-03-01 | Nat Res Dev | Immunological preparations |
JPS53107408A (en) * | 1977-02-28 | 1978-09-19 | Yamanouchi Pharmaceut Co Ltd | Micellar preparation for rectal infusion |
US4530832A (en) * | 1978-12-07 | 1985-07-23 | Schering Corporation | Method of vaccination for prevention of Bordetella bronchiseptica infection |
FR2501526A1 (fr) * | 1981-03-13 | 1982-09-17 | Montagne Noire Produits Chimiq | Nouveaux emulsionnants et leur application pour la production de vaccins |
ES2193134T3 (es) * | 1991-06-26 | 2003-11-01 | Yamanouchi Europ Bv | Procedimiento para la preparacion de dispersiones de vesiculas encapsuladas. |
WO1999021533A2 (en) * | 1997-10-24 | 1999-05-06 | Neorx Corporation | Delivery vehicles for bioactive agents and uses thereof |
US8703095B2 (en) * | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE25721E (en) * | 1965-01-26 | Swine erysipelas vaccine | ||
US2966443A (en) * | 1959-06-22 | 1960-12-27 | American Cyanamid Co | Trivalent poliomyelitis live virus vaccine |
US3099601A (en) * | 1959-10-02 | 1963-07-30 | Anchor Serum Company | Bacterin in aqueous polyethylene, mineral oil emulsion |
US3096249A (en) * | 1960-05-10 | 1963-07-02 | Samuel J Prigal | Emulsion composition |
GB914894A (en) * | 1960-08-12 | 1963-01-09 | Beecham Res Lab | Injectable pharmaceutical media |
US3149036A (en) * | 1961-10-16 | 1964-09-15 | Merck & Co Inc | Adjuvant vaccine with aluminum monostearate, mannide monooleate, vegetable oil, and an aqueous phase immunolgical agent |
US3185625A (en) * | 1961-11-08 | 1965-05-25 | Brown Ethan Allan | Injectionable substances |
-
1966
- 1966-06-08 GB GB25595/66A patent/GB1171125A/en not_active Expired
-
1967
- 1967-06-01 US US642727A patent/US3384544A/en not_active Expired - Lifetime
- 1967-06-02 NL NL6707702.A patent/NL159283B/xx unknown
- 1967-06-06 IT IT37275/67A patent/IT1035004B/it active
- 1967-06-08 BE BE699678D patent/BE699678A/xx unknown
- 1967-09-05 FR FR119939A patent/FR7316M/fr not_active Expired
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0059521A1 (de) * | 1981-03-03 | 1982-09-08 | Centraal Diergeneeskundig Instituut | Wasser-in-Öl-Emulsion zur Verwendung bei der Verstärkung des Immunosystems von Tieren |
EP0202837A1 (de) * | 1985-05-17 | 1986-11-26 | Smithkline Beckman Corporation | Zusammensetzung in Form einer Emulsion mit einem Gehalt von Polyenantibiotikum |
US5866159A (en) * | 1988-09-16 | 1999-02-02 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
US7235248B2 (en) | 1988-09-16 | 2007-06-26 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
US6024978A (en) * | 1988-09-16 | 2000-02-15 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
US5962017A (en) * | 1988-09-16 | 1999-10-05 | Novartis G | Pharmaceutical compositions comprising cyclosporins |
US5962014A (en) * | 1988-09-16 | 1999-10-05 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
US5916589A (en) * | 1988-09-16 | 1999-06-29 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
US5741512A (en) * | 1988-09-16 | 1998-04-21 | Novartis Corporation | Pharmaceutical compositions comprising cyclosporins |
US5688761A (en) * | 1991-04-19 | 1997-11-18 | Lds Technologies, Inc. | Convertible microemulsion formulations |
WO1992018147A1 (en) * | 1991-04-19 | 1992-10-29 | Affinity Biotech, Inc. | Convertible microemulsion formulations |
US5633226A (en) * | 1991-04-19 | 1997-05-27 | Lds Technologies, Inc. | Convertible microemulsion formulations |
US5444041A (en) * | 1991-04-19 | 1995-08-22 | Ibah, Inc. | Convertible microemulsion formulations |
US5646109A (en) * | 1991-04-19 | 1997-07-08 | Lds Technologies, Inc. | Convertible microemulsion formulations |
US6844459B2 (en) | 1991-06-27 | 2005-01-18 | Novartis Ag | Pharmaceutical Composition |
US6258808B1 (en) | 1991-06-27 | 2001-07-10 | Novartis Ag | Pharmaceutical composition |
US6582718B2 (en) | 1992-05-13 | 2003-06-24 | Novartis Ag | Cyclosporin compositions |
US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
US6420355B2 (en) | 1992-09-25 | 2002-07-16 | Novartis Ag | Pharmaceutical compositions containing cyclosporins |
WO1994008610A1 (en) * | 1992-10-16 | 1994-04-28 | Smithkline Beecham Corporation | Pharmaceutical emulsion compositions |
WO1994017827A1 (en) * | 1993-02-15 | 1994-08-18 | Lyfjathroun H.F. | A pharmaceutical preparation for topical administration of antigens and/or vaccines to mammals via a mucosal membrane |
US5942237A (en) * | 1993-02-15 | 1999-08-24 | Lyfjathroun H.F. | Pharmaceutical preparation for topical administration of antigens and/or vaccines to mammals via a mucosal membrane |
US6486124B2 (en) | 1994-11-03 | 2002-11-26 | Novartis Ag | Cyclosporin compositions and process therefor |
US5989566A (en) * | 1995-06-30 | 1999-11-23 | American Cyanamid Company | Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation |
US6951841B2 (en) | 1995-11-29 | 2005-10-04 | Novartis Ag | Pharmaceutical compositions of macrolides or cyclosporine with a polyethoxylated saturated hydroxy-fatty acid |
US6245349B1 (en) | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
US6214367B1 (en) | 1996-06-05 | 2001-04-10 | Ashmont Holdings Limited | Injectable compositions |
US6663879B2 (en) | 1996-06-05 | 2003-12-16 | Ashmont Holdings Limited | Injectable compositions |
US6475519B1 (en) | 1997-01-30 | 2002-11-05 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin A |
US6723339B2 (en) | 1997-01-30 | 2004-04-20 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin A |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
Also Published As
Publication number | Publication date |
---|---|
NL159283B (nl) | 1979-02-15 |
NL6707702A (de) | 1967-12-11 |
IT1035004B (it) | 1979-10-20 |
US3384544A (en) | 1968-05-21 |
BE699678A (de) | 1967-12-08 |
FR7316M (de) | 1969-10-06 |
DE1617502A1 (de) | 1972-02-10 |
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