GB1165745A - Novel Dinucleoside Phosphates - Google Patents
Novel Dinucleoside PhosphatesInfo
- Publication number
- GB1165745A GB1165745A GB38868/66A GB3886866A GB1165745A GB 1165745 A GB1165745 A GB 1165745A GB 38868/66 A GB38868/66 A GB 38868/66A GB 3886866 A GB3886866 A GB 3886866A GB 1165745 A GB1165745 A GB 1165745A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- formula
- uracil
- preparation
- formulμ
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002862 dinucleoside phosphate Substances 0.000 title abstract 4
- -1 hydrocarbon carboxylic acid Chemical class 0.000 abstract 14
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000002360 preparation method Methods 0.000 abstract 4
- PEHVGBZKEYRQSX-UHFFFAOYSA-N 7-deaza-adenine Chemical class NC1=NC=NC2=C1C=CN2 PEHVGBZKEYRQSX-UHFFFAOYSA-N 0.000 abstract 2
- 241000187747 Streptomyces Species 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- HDZZVAMISRMYHH-KCGFPETGSA-N tubercidin Chemical compound C1=CC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O HDZZVAMISRMYHH-KCGFPETGSA-N 0.000 abstract 2
- 125000000845 uracil-1-yl group Chemical group [*]N1C(=O)N([H])C(=O)C([H])=C1[H] 0.000 abstract 2
- YBBDIXWREGHZRM-DYXQDRAXSA-N (3s,4r,5r)-2-chloro-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolane Chemical compound C([C@H]1OC([C@H]([C@@H]1OCC=1C=CC=CC=1)OCC=1C=CC=CC=1)Cl)OCC1=CC=CC=C1 YBBDIXWREGHZRM-DYXQDRAXSA-N 0.000 abstract 1
- NJDPBWLDVFCXNP-UHFFFAOYSA-L 2-cyanoethyl phosphate Chemical compound [O-]P([O-])(=O)OCCC#N NJDPBWLDVFCXNP-UHFFFAOYSA-L 0.000 abstract 1
- CVICEEPAFUYBJG-UHFFFAOYSA-N 5-chloro-2,2-difluoro-1,3-benzodioxole Chemical group C1=C(Cl)C=C2OC(F)(F)OC2=C1 CVICEEPAFUYBJG-UHFFFAOYSA-N 0.000 abstract 1
- MSSXOMSJDRHRMC-UHFFFAOYSA-N 9H-purine-2,6-diamine Chemical group NC1=NC(N)=C2NC=NC2=N1 MSSXOMSJDRHRMC-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 241000700618 Vaccinia virus Species 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000000848 adenin-9-yl group Chemical group [H]N([H])C1=C2N=C([H])N(*)C2=NC([H])=N1 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- RCTYPNKXASFOBE-UHFFFAOYSA-M chloromercury Chemical class [Hg]Cl RCTYPNKXASFOBE-UHFFFAOYSA-M 0.000 abstract 1
- 125000000847 cytosin-1-yl group Chemical group [*]N1C(=O)N=C(N([H])[H])C([H])=C1[H] 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 230000000865 phosphorylative effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000008223 ribosides Chemical class 0.000 abstract 1
- 239000002689 soil Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
- 125000003294 thymin-1-yl group Chemical group [H]N1C(=O)N(*)C([H])=C(C1=O)C([H])([H])[H] 0.000 abstract 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/905—Streptomyces sparogenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US488724A US3337530A (en) | 1965-09-20 | 1965-09-20 | Dinucleoside 3', 5' -and 2', 5'-phosphates containing one 7-deazapurin riboside moiety |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1165745A true GB1165745A (en) | 1969-10-01 |
Family
ID=23940843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB38868/66A Expired GB1165745A (en) | 1965-09-20 | 1966-08-31 | Novel Dinucleoside Phosphates |
Country Status (7)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3457255A (en) * | 1967-05-17 | 1969-07-22 | Syntex Corp | Novel ribo and lyxo nucleoside derivatives and a process for their preparation |
| US3446793A (en) * | 1967-10-30 | 1969-05-27 | Syntex Corp | 3'-cyclic esters of 5'-deoxy-5'-(dihydroxyphosphinylmethyl)-nucleosides |
| US4093714A (en) * | 1974-03-15 | 1978-06-06 | Icn Pharmaceuticals, Inc. | 9β-D-Arabinofuranosylpurine nucleotides and method of use |
| GB1562899A (en) * | 1975-06-17 | 1980-03-19 | Wellcome Found | Pharmaceutical compositions containing substituted 9-( -d-arabnofuranosyl)purine-5'-phosphate and salts thereof |
| US4189349A (en) * | 1977-09-19 | 1980-02-19 | Rhone-Poulenc Industries | α,δ-Diaminoacid and its lactam |
| US4464359A (en) * | 1981-04-10 | 1984-08-07 | Research Corporation | (2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof |
| US4539313A (en) * | 1981-04-10 | 1985-09-03 | Research Corporation | (2'-5')-Oligo (3'-deoxyandenylate) and derivatives thereof |
| US4708935A (en) * | 1981-04-10 | 1987-11-24 | Research Corporation | (2-5')-Oligo (3'-deoxyadenylate) and derivatives thereof |
| US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| DE3529478A1 (de) * | 1985-08-16 | 1987-02-19 | Boehringer Mannheim Gmbh | 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung |
| US5594121A (en) * | 1991-11-07 | 1997-01-14 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
| AU6632094A (en) * | 1993-04-19 | 1994-11-08 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
| CA2451738C (en) | 2001-07-06 | 2013-09-17 | Topigen Pharmaceutique Inc. | Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals using 2-amino-2'-deoxyadenosine |
| WO2006045202A1 (en) | 2004-10-29 | 2006-05-04 | Topigen Pharmaceuticals Inc. | Antisense oligonucleotides for treating allergy and neoplastic cell proliferation |
| CN113480867A (zh) * | 2021-07-27 | 2021-10-08 | 晶锋集团股份有限公司 | 一种新型氟材料耐高温控制电缆材料及其制备方法 |
-
1965
- 1965-09-20 US US488724A patent/US3337530A/en not_active Expired - Lifetime
-
1966
- 1966-08-30 IL IL26421A patent/IL26421A/xx unknown
- 1966-08-31 GB GB38868/66A patent/GB1165745A/en not_active Expired
- 1966-09-06 NL NL6612538A patent/NL6612538A/xx unknown
- 1966-09-17 DE DE19661620643 patent/DE1620643A1/de active Pending
- 1966-09-19 FR FR76881A patent/FR1502815A/fr not_active Expired
- 1966-09-20 CH CH1350166A patent/CH482687A/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE1620643A1 (de) | 1970-05-14 |
| FR1502815A (fr) | 1967-11-24 |
| US3337530A (en) | 1967-08-22 |
| IL26421A (en) | 1970-12-24 |
| CH482687A (de) | 1969-12-15 |
| NL6612538A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1967-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |