GB1164838A - New Peptides having an Acth-Action and Process for their Manufacture - Google Patents

Info

Publication number

GB1164838A

GB1164838A GB5089666A GB5089666A GB1164838A GB 1164838 A GB1164838 A GB 1164838A GB 5089666 A GB5089666 A GB 5089666A GB 5089666 A GB5089666 A GB 5089666A GB 1164838 A GB1164838 A GB 1164838A

Authority

GB

United Kingdom

Prior art keywords

boc

lys

val

pro

tyr

Prior art date

1965-11-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
• 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
• 238000004519 manufacturing process Methods 0.000 title 1
• 238000000034 method Methods 0.000 title 1
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 3
• 125000000539 amino acid group Chemical group 0.000 abstract 2
• 108010015792 glycyllysine Proteins 0.000 abstract 2
• 108010009962 valyltyrosine Proteins 0.000 abstract 2
• 239000000275 Adrenocorticotropic Hormone Substances 0.000 abstract 1
• 101800000414 Corticotropin Proteins 0.000 abstract 1
• 235000019766 L-Lysine Nutrition 0.000 abstract 1
• 125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 abstract 1
• 239000004472 Lysine Substances 0.000 abstract 1
• FUOGXAQMNJMBFG-WPRPVWTQSA-N Pro-Val-Gly Chemical compound OC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1 FUOGXAQMNJMBFG-WPRPVWTQSA-N 0.000 abstract 1
• 239000002253 acid Substances 0.000 abstract 1
• 150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
• 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
• 150000001408 amides Chemical class 0.000 abstract 1
• 150000001875 compounds Chemical class 0.000 abstract 1
• IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
• 229960000258 corticotropin Drugs 0.000 abstract 1
• 150000002148 esters Chemical class 0.000 abstract 1
• 239000003701 inert diluent Substances 0.000 abstract 1
• 239000000543 intermediate Substances 0.000 abstract 1
• 239000000203 mixture Substances 0.000 abstract 1
• 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
• 239000008194 pharmaceutical composition Substances 0.000 abstract 1
• 229920001184 polypeptide Polymers 0.000 abstract 1
• 150000003839 salts Chemical class 0.000 abstract 1
• 238000010561 standard procedure Methods 0.000 abstract 1
• 239000007858 starting material Substances 0.000 abstract 1
• 239000000126 substance Substances 0.000 abstract 1