GB1164809A - Octadecapeptides and Process for their Manufature - Google Patents

Octadecapeptides and Process for their Manufature

Info

Publication number
GB1164809A
GB1164809A GB50895/66A GB5089566A GB1164809A GB 1164809 A GB1164809 A GB 1164809A GB 50895/66 A GB50895/66 A GB 50895/66A GB 5089566 A GB5089566 A GB 5089566A GB 1164809 A GB1164809 A GB 1164809A
Authority
GB
United Kingdom
Prior art keywords
lys
boc
gly
ser
glu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB50895/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB1164809A publication Critical patent/GB1164809A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1,164,809. Octadecapeptides. CIBA Ltd. 14 Nov., 1966 [12 Nov., 1965], No. 50895/66. Addition to 1,119,353. Heading C2C. H - D - Ser - Tyr - Ser - Met - Glu (OH) [or Glu(NH 2 )] His-Phe-Arg-Try-Gly-Lys-Pro- Val-Gly-Lys-Lys-Lys-Lys-OH (D-Ser<SP>1</SP>-Lip<SP>17,18</SP>- #<SP>1-18</SP>-corticotrophin) its derivatives (including its esters, amides and blocked terminal amino groups), its acid addition salts and complexes thereof with inorganic or organic substances capable of prolonging the activity as prepared by known methods for forming polypeptides, especially the decapeptide H-D-Ser-Tyr-Ser- Met-Gly(OH )-[or-Glu(NH 2 )]-His- Phe -Arg -Try- Gly(OH) is condensed with the octapeptide H - Lys - Pro - Val - Gly - Lys - Lys - Lys - Lys-OH (any free NH 2 and COOH group in the peptide fragments being suitably protected) and the protecting groups (especially BOC-) being split off. The following starting materials and intermediates are prepared: Z-Lys(BOC)-Lys(BOC)- NH 2 , H - Lys(BOC) - Lys(BOC) - NH 2 , ZLys(BOC) - Pro - Val - Gly - Lys(BOC) - Lys- (BOC) - Lys(BOC) - Lys(BOC) - NH 2 and the N-unprotected peptidamide, and BOC-D-Ser- Tyr-Ser-Met-Glu(OtBu) His-Phe-Arg-Try-Gly- Lys(BOC) - Pro - Val - Gly - Lys(BOC) - Lys- (BOC)-Lys(BOC)-(Lys)BOC) -NH 2 . Pharmaceutical compositions comprise the compounds of the invention, especially complexes thereof which prolong the activity, together with an inert diluent or carrier. The compositions may be in a form suitable for central and parenteral administration.
GB50895/66A 1965-11-12 1966-11-14 Octadecapeptides and Process for their Manufature Expired GB1164809A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1563865A CH516521A (en) 1965-11-12 1965-11-12 Peptides with acth activity

Publications (1)

Publication Number Publication Date
GB1164809A true GB1164809A (en) 1969-09-24

Family

ID=4410720

Family Applications (1)

Application Number Title Priority Date Filing Date
GB50895/66A Expired GB1164809A (en) 1965-11-12 1966-11-14 Octadecapeptides and Process for their Manufature

Country Status (12)

Country Link
AT (1) AT292208B (en)
BE (1) BE689575A (en)
BR (1) BR6684476D0 (en)
CH (1) CH516521A (en)
DE (1) DE1543501C3 (en)
FI (1) FI47760C (en)
FR (1) FR5849M (en)
GB (1) GB1164809A (en)
NL (1) NL141174B (en)
NO (1) NO126480B (en)
OA (1) OA105E (en)
SE (1) SE345448B (en)

Also Published As

Publication number Publication date
FI47760B (en) 1973-11-30
NL141174B (en) 1974-02-15
CH516521A (en) 1971-12-15
NO126480B (en) 1973-02-12
SE345448B (en) 1972-05-29
FR5849M (en) 1968-03-04
BR6684476D0 (en) 1973-12-26
DE1543501A1 (en) 1972-04-20
BE689575A (en) 1967-05-10
AT292208B (en) 1971-08-25
NL6615965A (en) 1967-05-16
DE1543501B2 (en) 1974-03-21
OA105E (en) 1970-12-15
DE1543501C3 (en) 1974-11-07
FI47760C (en) 1974-03-11

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee