GB1161896A - Process for the Manufacture of a New Polypeptide - Google Patents

Process for the Manufacture of a New Polypeptide

Info

Publication number
GB1161896A
GB1161896A GB37968/66A GB3796866A GB1161896A GB 1161896 A GB1161896 A GB 1161896A GB 37968/66 A GB37968/66 A GB 37968/66A GB 3796866 A GB3796866 A GB 3796866A GB 1161896 A GB1161896 A GB 1161896A
Authority
GB
United Kingdom
Prior art keywords
acid
polypeptide
aug
extract
thyroid gland
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB37968/66A
Inventor
Iain Macintyre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB1161896A publication Critical patent/GB1161896A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00—Ion-exchange processes in general; Apparatus therefor
    • B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1,161,896. Thyroid gland polypeptides. I. MACINTYRE. 24 Aug., 1966 [26 Aug., 1965; 7 Jan., 1966; 11 July, 1966],. No. 37968/ 66. Heading A5B. A hypocalcaemic polypaptide is obtained from mammalian thyroid gland by extraction with aqueous acid, salt fractionation of the extract, and absorption on gel and elution therefrom in formic acid solution, followed by lyophilisation or evaporation to give the product. The process preferably includes a dialysis of the acid extract, and precipitation with trichloracetic acid at any stage subsequent to the salt fractionation. The preferred starting material is a defatted acetone powder of pigs' thyroid. The polypeptide has a molecular weight of about 2700, and contains most common L-amino acides excepting cystine. Pharmaceutical compositions comprise the polypeptide or its physiologically tolerable acid addition salts or complexes with a carrier, in a form suitable for internal or parenteral administration, and may also contain further unspecified active ingredients. The polypeptide may be reacted with bases or acids, or may be complexed with e.g. hydroxypolygelatin, polyvinyl pyrrolidone, Protamine, polyphloretin phosphate, phytic acid, polyglutamic acid, or suitable sparingly soluble metal compounds; such as Al, Mg, Co, or Zn phosphates, pyrophosphates or hydroxides, to provide, prolonged release forms.
GB37968/66A 1965-08-26 1966-08-24 Process for the Manufacture of a New Polypeptide Expired GB1161896A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH1201765 1965-08-26
CH19566 1966-01-07
CH1004366 1966-07-11

Publications (1)

Publication Number Publication Date
GB1161896A true GB1161896A (en) 1969-08-20

Family

ID=27171894

Family Applications (1)

Application Number Title Priority Date Filing Date
GB37968/66A Expired GB1161896A (en) 1965-08-26 1966-08-24 Process for the Manufacture of a New Polypeptide

Country Status (4)

Country Link
BE (1) BE685991A (en)
FR (2) FR1508124A (en)
GB (1) GB1161896A (en)
NL (1) NL6612009A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA010720B1 (en) * 2006-01-31 2008-10-30 Общество С Ограниченной Ответственностью "Гармония" Method for preparing a medicament for supporting therapy exhibiting tissue-specific activity, and a medicament obtained thereof (embodiments)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA010720B1 (en) * 2006-01-31 2008-10-30 Общество С Ограниченной Ответственностью "Гармония" Method for preparing a medicament for supporting therapy exhibiting tissue-specific activity, and a medicament obtained thereof (embodiments)

Also Published As

Publication number Publication date
BE685991A (en) 1967-02-27
NL6612009A (en) 1967-02-27
FR6866M (en) 1969-04-14
FR1508124A (en) 1968-01-05

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]