GB1159290A - Fermentation process for 9-(beta-D-Arabinofuranosyl) Adenine - Google Patents
Fermentation process for 9-(beta-D-Arabinofuranosyl) AdenineInfo
- Publication number
- GB1159290A GB1159290A GB5918067A GB5918067A GB1159290A GB 1159290 A GB1159290 A GB 1159290A GB 5918067 A GB5918067 A GB 5918067A GB 5918067 A GB5918067 A GB 5918067A GB 1159290 A GB1159290 A GB 1159290A
- Authority
- GB
- United Kingdom
- Prior art keywords
- arabinofuranosyl
- adenine
- water
- aqueous
- elution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000855 fermentation Methods 0.000 title abstract 2
- 230000004151 fermentation Effects 0.000 title abstract 2
- OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 title 1
- 229930024421 Adenine Natural products 0.000 abstract 3
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 3
- 229960000643 adenine Drugs 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 241000186988 Streptomyces antibioticus Species 0.000 abstract 2
- 238000009835 boiling Methods 0.000 abstract 2
- 238000010828 elution Methods 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 2
- 238000001179 sorption measurement Methods 0.000 abstract 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 abstract 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000003729 cation exchange resin Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60604466A | 1966-12-30 | 1966-12-30 | |
| US67155767A | 1967-09-29 | 1967-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1159290A true GB1159290A (en) | 1969-07-23 |
Family
ID=27085121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5918067A Expired GB1159290A (en) | 1966-12-30 | 1967-12-29 | Fermentation process for 9-(beta-D-Arabinofuranosyl) Adenine |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT281301B (enrdf_load_stackoverflow) |
| BE (1) | BE708821A (enrdf_load_stackoverflow) |
| CH (1) | CH478241A (enrdf_load_stackoverflow) |
| DE (1) | DE1695598B2 (enrdf_load_stackoverflow) |
| DK (1) | DK120561B (enrdf_load_stackoverflow) |
| ES (1) | ES348802A1 (enrdf_load_stackoverflow) |
| FR (1) | FR1576370A (enrdf_load_stackoverflow) |
| GB (1) | GB1159290A (enrdf_load_stackoverflow) |
| NL (1) | NL143989B (enrdf_load_stackoverflow) |
| SE (1) | SE347287B (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002192A1 (en) * | 1977-11-03 | 1979-06-13 | The Wellcome Foundation Limited | Enzymatic synthesis of purine arabinonucleosides |
| WO1995032212A1 (de) * | 1994-05-20 | 1995-11-30 | Schering Aktiengesellschaft | Verfahren zur herstellung von arabinonukleosiden |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2006185B (en) * | 1977-08-10 | 1982-04-28 | Ajinomoto Kk | Method for producing purine arabinosides |
| DE2816441C2 (de) * | 1978-04-15 | 1982-01-14 | Lechler Gmbh & Co Kg, 7012 Fellbach | Vorrichtung zum Aufsprühen eines Treib- und Kühlmittels auf eine Strangguß-Stahlbramme |
-
1967
- 1967-12-29 FR FR1576370D patent/FR1576370A/fr not_active Expired
- 1967-12-29 NL NL6717839A patent/NL143989B/xx not_active IP Right Cessation
- 1967-12-29 DE DE19671695598 patent/DE1695598B2/de active Granted
- 1967-12-29 CH CH1832467A patent/CH478241A/fr not_active IP Right Cessation
- 1967-12-29 GB GB5918067A patent/GB1159290A/en not_active Expired
- 1967-12-29 SE SE1799767A patent/SE347287B/xx unknown
- 1967-12-29 DK DK659667A patent/DK120561B/da not_active IP Right Cessation
- 1967-12-29 ES ES348802A patent/ES348802A1/es not_active Expired
- 1967-12-29 BE BE708821D patent/BE708821A/xx not_active IP Right Cessation
- 1967-12-29 AT AT1176367A patent/AT281301B/de not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002192A1 (en) * | 1977-11-03 | 1979-06-13 | The Wellcome Foundation Limited | Enzymatic synthesis of purine arabinonucleosides |
| WO1995032212A1 (de) * | 1994-05-20 | 1995-11-30 | Schering Aktiengesellschaft | Verfahren zur herstellung von arabinonukleosiden |
Also Published As
| Publication number | Publication date |
|---|---|
| ES348802A1 (es) | 1969-07-16 |
| AT281301B (de) | 1970-05-11 |
| BE708821A (enrdf_load_stackoverflow) | 1968-05-02 |
| DE1695598B2 (de) | 1973-05-10 |
| CH478241A (fr) | 1969-09-15 |
| DE1695598C3 (enrdf_load_stackoverflow) | 1973-11-29 |
| NL6717839A (enrdf_load_stackoverflow) | 1968-07-01 |
| DK120561B (da) | 1971-06-14 |
| SE347287B (enrdf_load_stackoverflow) | 1972-07-31 |
| NL143989B (nl) | 1974-11-15 |
| DE1695598A1 (de) | 1972-01-13 |
| FR1576370A (enrdf_load_stackoverflow) | 1969-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |