GB1159290A - Fermentation process for 9-(beta-D-Arabinofuranosyl) Adenine - Google Patents

Fermentation process for 9-(beta-D-Arabinofuranosyl) Adenine

Info

Publication number
GB1159290A
GB1159290A GB5918067A GB5918067A GB1159290A GB 1159290 A GB1159290 A GB 1159290A GB 5918067 A GB5918067 A GB 5918067A GB 5918067 A GB5918067 A GB 5918067A GB 1159290 A GB1159290 A GB 1159290A
Authority
GB
United Kingdom
Prior art keywords
arabinofuranosyl
adenine
water
aqueous
elution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5918067A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of GB1159290A publication Critical patent/GB1159290A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

1,159,290. 9 - (# - D - arabinofuranosyl) adenine. PARKE, DAVIS & CO. 29 Dec., 1967 [30 Dec., 1966; 29 Sept., 1967], No. 69180/67. Heading C2C. 9-(#-D-arabinofuranosyl) adenine of formula which is effective against viruses, is produced by cultivating a 9-(#-D-arabinofuranosyl) adenine-producing strain of Streptomyces antibioticus in an aqueous nutrient medium under surface or submerged aerobic conditions. The described microorganism is S. antibioticus NRRL 3238. The antibiotic may be isolated from the clarified fermentation broth by (A) concentrating the broth to <SP>1</SP>/ 12 th the original volume, cooling to 5‹ C. and filtering with a filter aid. The cake is extracted with boiling water, cooled to 5‹ C. and the precipitated crude recrystallized from boiling water; (B) adsorption on activated carbon followed by elution with aqueous acetone or aqueous alkanol. In the case of (B), a preliminary treatment may be given by extraction with an immiscible organic solvent such as ethylene dichloride or ethyl acetate or by treatment with a cation exchange resin in the sodium form. Further purification is by extraction of the crude with a water-immiscible alkanol such as n-butyl alcohol, adsorption on alumina pH 5-6, followed by elution with 95% ethanol and recrystallization from water or alcohol.
GB5918067A 1966-12-30 1967-12-29 Fermentation process for 9-(beta-D-Arabinofuranosyl) Adenine Expired GB1159290A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60604466A 1966-12-30 1966-12-30
US67155767A 1967-09-29 1967-09-29

Publications (1)

Publication Number Publication Date
GB1159290A true GB1159290A (en) 1969-07-23

Family

ID=27085121

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5918067A Expired GB1159290A (en) 1966-12-30 1967-12-29 Fermentation process for 9-(beta-D-Arabinofuranosyl) Adenine

Country Status (10)

Country Link
AT (1) AT281301B (en)
BE (1) BE708821A (en)
CH (1) CH478241A (en)
DE (1) DE1695598B2 (en)
DK (1) DK120561B (en)
ES (1) ES348802A1 (en)
FR (1) FR1576370A (en)
GB (1) GB1159290A (en)
NL (1) NL143989B (en)
SE (1) SE347287B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002192A1 (en) * 1977-11-03 1979-06-13 The Wellcome Foundation Limited Enzymatic synthesis of purine arabinonucleosides
WO1995032212A1 (en) * 1994-05-20 1995-11-30 Schering Aktiengesellschaft Process for producing arabino-nucleosides

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2006185B (en) * 1977-08-10 1982-04-28 Ajinomoto Kk Method for producing purine arabinosides
DE2816441C2 (en) * 1978-04-15 1982-01-14 Lechler Gmbh & Co Kg, 7012 Fellbach Device for spraying a propellant and coolant onto a continuously cast steel slab

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002192A1 (en) * 1977-11-03 1979-06-13 The Wellcome Foundation Limited Enzymatic synthesis of purine arabinonucleosides
WO1995032212A1 (en) * 1994-05-20 1995-11-30 Schering Aktiengesellschaft Process for producing arabino-nucleosides

Also Published As

Publication number Publication date
DE1695598A1 (en) 1972-01-13
SE347287B (en) 1972-07-31
BE708821A (en) 1968-05-02
FR1576370A (en) 1969-08-01
CH478241A (en) 1969-09-15
AT281301B (en) 1970-05-11
ES348802A1 (en) 1969-07-16
NL143989B (en) 1974-11-15
NL6717839A (en) 1968-07-01
DE1695598B2 (en) 1973-05-10
DK120561B (en) 1971-06-14
DE1695598C3 (en) 1973-11-29

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Legal Events

Date Code Title Description
PS Patent sealed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee