ES348802A1 - Fermentation process for 9-(beta-D-Arabinofuranosyl) Adenine - Google Patents

Fermentation process for 9-(beta-D-Arabinofuranosyl) Adenine

Info

Publication number
ES348802A1
ES348802A1 ES348802A ES348802A ES348802A1 ES 348802 A1 ES348802 A1 ES 348802A1 ES 348802 A ES348802 A ES 348802A ES 348802 A ES348802 A ES 348802A ES 348802 A1 ES348802 A1 ES 348802A1
Authority
ES
Spain
Prior art keywords
arabinofuranosyl
adenine
water
aqueous
elution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES348802A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of ES348802A1 publication Critical patent/ES348802A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

9-(#-D-arabinofuranosyl) adenine of formula which is effective against viruses, is produced by cultivating a 9-(#-D-arabinofuranosyl) adenine-producing strain of Streptomyces antibioticus in an aqueous nutrient medium under surface or submerged aerobic conditions. The described microorganism is S. antibioticus NRRL 3238. The antibiotic may be isolated from the clarified fermentation broth by (A) concentrating the broth to 1/ 12 th the original volume, cooling to 5 C. and filtering with a filter aid. The cake is extracted with boiling water, cooled to 5 C. and the precipitated crude recrystallized from boiling water (B) adsorption on activated carbon followed by elution with aqueous acetone or aqueous alkanol. In the case of (B), a preliminary treatment may be given by extraction with an immiscible organic solvent such as ethylene dichloride or ethyl acetate or by treatment with a cation exchange resin in the sodium form. Further purification is by extraction of the crude with a water-immiscible alkanol such as n-butyl alcohol, adsorption on alumina pH 5-6, followed by elution with 95% ethanol and recrystallization from water or alcohol.
ES348802A 1966-12-30 1967-12-29 Fermentation process for 9-(beta-D-Arabinofuranosyl) Adenine Expired ES348802A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60604466A 1966-12-30 1966-12-30
US67155767A 1967-09-29 1967-09-29

Publications (1)

Publication Number Publication Date
ES348802A1 true ES348802A1 (en) 1969-07-16

Family

ID=27085121

Family Applications (1)

Application Number Title Priority Date Filing Date
ES348802A Expired ES348802A1 (en) 1966-12-30 1967-12-29 Fermentation process for 9-(beta-D-Arabinofuranosyl) Adenine

Country Status (10)

Country Link
AT (1) AT281301B (en)
BE (1) BE708821A (en)
CH (1) CH478241A (en)
DE (1) DE1695598B2 (en)
DK (1) DK120561B (en)
ES (1) ES348802A1 (en)
FR (1) FR1576370A (en)
GB (1) GB1159290A (en)
NL (1) NL143989B (en)
SE (1) SE347287B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2006185B (en) * 1977-08-10 1982-04-28 Ajinomoto Kk Method for producing purine arabinosides
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
DE2816441C2 (en) * 1978-04-15 1982-01-14 Lechler Gmbh & Co Kg, 7012 Fellbach Device for spraying a propellant and coolant onto a continuously cast steel slab
DE4418474A1 (en) * 1994-05-20 1995-11-23 Schering Ag Process for the preparation of arabinonucleosides

Also Published As

Publication number Publication date
DE1695598A1 (en) 1972-01-13
SE347287B (en) 1972-07-31
BE708821A (en) 1968-05-02
FR1576370A (en) 1969-08-01
CH478241A (en) 1969-09-15
AT281301B (en) 1970-05-11
GB1159290A (en) 1969-07-23
NL143989B (en) 1974-11-15
NL6717839A (en) 1968-07-01
DE1695598B2 (en) 1973-05-10
DK120561B (en) 1971-06-14
DE1695598C3 (en) 1973-11-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19860226