GB1157639A - Amino-Valeramide Derivatives and Process for their Preparation - Google Patents

Amino-Valeramide Derivatives and Process for their Preparation

Info

Publication number
GB1157639A
GB1157639A GB174769A GB174769A GB1157639A GB 1157639 A GB1157639 A GB 1157639A GB 174769 A GB174769 A GB 174769A GB 174769 A GB174769 A GB 174769A GB 1157639 A GB1157639 A GB 1157639A
Authority
GB
United Kingdom
Prior art keywords
alkyl
valeramide
derivatives
valeronitrile
july
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB174769A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of GB1157639A publication Critical patent/GB1157639A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1,157,639. Amino-valeramide derivatives and process for their preparation. STERLING DRUG Inc. 1 July, 1966 [1 July, 1965], No. 1747/69. Divided out of 1,157,637. Heading C2C. Compounds of the formulae may be obtained by hydrolysing 2-methyl-5- NR 1 R 2 -valeronitrile or 4 - methyl - 5 - NR 1 R 2 - valeronitrile, preferably in an aqueous mineral acid, where -NR 1 R 2 is a tertiary amino group and R 1 and R 2 are the same or different and represent lower or higher alkyl, hydroxy lower or higher alkyl, lower alkoxy higher or lower alkyl, di-lower alkylamino lower or higher alkyl, C 3-7 cycloalkyl, phenyl or substituted phenyl, said substitutents being hydroxy, lower alkoxy, di-lower alkylamino, trifluoromethyl, lower alkylmercapto or halo or R 1 and R 2 taken together form a heterocyclic ring containing at least one heteroatom, the terms " lower " and " higher " denoting C 1-8 and C 8-18 respectively. The hydrolysis is preferably effected at 60-65‹ C. in 85-95% sulphuric or phosphoric acid. The aminonitrile starting material is suitably that obtained by catalytically hydrogenating 2-methylene glutaronitrile and reductively alkylating the product in the presence of an amine, HNR 1 R 2 À
GB174769A 1965-07-01 1966-07-01 Amino-Valeramide Derivatives and Process for their Preparation Expired GB1157639A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46895865A 1965-07-01 1965-07-01

Publications (1)

Publication Number Publication Date
GB1157639A true GB1157639A (en) 1969-07-09

Family

ID=23861890

Family Applications (3)

Application Number Title Priority Date Filing Date
GB174769A Expired GB1157639A (en) 1965-07-01 1966-07-01 Amino-Valeramide Derivatives and Process for their Preparation
GB2963666A Expired GB1157637A (en) 1965-07-01 1966-07-01 Process for the Production of Tertiary-Amino Alkylated Primary Amines
GB174669A Expired GB1157638A (en) 1965-07-01 1966-07-01 Aminonitrile Derivatives and Process for their Preparation

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB2963666A Expired GB1157637A (en) 1965-07-01 1966-07-01 Process for the Production of Tertiary-Amino Alkylated Primary Amines
GB174669A Expired GB1157638A (en) 1965-07-01 1966-07-01 Aminonitrile Derivatives and Process for their Preparation

Country Status (1)

Country Link
GB (3) GB1157639A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5463130A (en) * 1994-03-07 1995-10-31 Basf Aktiengesellschaft Preparation of peralkylated amines
US5557011A (en) * 1992-11-26 1996-09-17 Basf Aktiengesellschaft Preparation of diamines

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910343A (en) * 1988-09-20 1990-03-20 W. R. Grace & Co.-Conn. Nitroamines
DE19825452A1 (en) * 1998-06-06 1999-12-09 Basf Ag Process for the preparation of secondary or tertiary 2-methyl-1,5-pentanediamines
CN104803859A (en) * 2015-04-17 2015-07-29 武汉瑞凯兴科技有限公司 Synthetic method of 5-(N-ethyl-N-2-ethylol amine)-2-amylamine
CN110616236B (en) * 2019-10-14 2021-02-26 暨明医药科技（苏州）有限公司 Preparation method of (R) -N1, N1-diethyl-1, 4-pentanediamine
CN111253263B (en) * 2020-02-17 2022-07-05 北京弗莱明科技有限公司 Preparation method of chloroquine key intermediate 2-amino-5-diethylaminopentane

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5557011A (en) * 1992-11-26 1996-09-17 Basf Aktiengesellschaft Preparation of diamines
US5463130A (en) * 1994-03-07 1995-10-31 Basf Aktiengesellschaft Preparation of peralkylated amines

Also Published As

Publication number Publication date
GB1157638A (en) 1969-07-09
GB1157637A (en) 1969-07-09

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees