GB1153114A - Fermentation processes and apparatus for Carrying Out the same - Google Patents

Fermentation processes and apparatus for Carrying Out the same

Info

Publication number
GB1153114A
GB1153114A GB361268A GB361268A GB1153114A GB 1153114 A GB1153114 A GB 1153114A GB 361268 A GB361268 A GB 361268A GB 361268 A GB361268 A GB 361268A GB 1153114 A GB1153114 A GB 1153114A
Authority
GB
United Kingdom
Prior art keywords
oxygen
atm
culture medium
cultivation
partial pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB361268A
Inventor
Yoshio Hirose
Hiroshi Sonoda
Shigeho Ikeda
Kazumoto Kinoshita
Sunao Yamashita
Hideo Noguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of GB1153114A publication Critical patent/GB1153114A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/20—Degassing; Venting; Bubble traps

Abstract

1,153,114. Amino acids; nucleosides by regulated fermentation. AJINOMOTO CO. Inc. 23 Jan., 1968 [6 Feb., 1967], No. 3612/68. Heading C2C. [Also in Divisions C6 and C7] A fermentation process involves culturing micro-organisms in a culture medium in a closed system, removing from the closed system carbon dioxide produced during the process, agitating the culture medium and feeding oxygen to the closed system at a desired controlled rate. A measurement of the partial pressure of oxygen in the liquid or gas phases within the system may be used for on-off control of an electrolytic cell providing oxygen, or of an oxygen cylinder. Alternatively, the amount of oxygen produced by an electrolytic cell 21, Fig. 3, operated under constant voltage potential may be regulated by the variation in level of the electrolyte 21 in the region of the electrode 20 produced by changes in the partial pressure of oxygen in the gas phase of the closed fermenter 1. In this embodiment the oxygen analyser 17 and recorder 18 do not participate in the control action. Carbon dioxide produced is removed by continuously circulating the gaseous phase through a solution of sodium or potassium hydroxide in a washing bottle 6. The fermenter itself may be agitated. Examples relate to the production of L- glutamic acid by cultivation of Corynebacterium acetoacidophilum ATCC 13870 on a specified glucose-containing culture medium in which a dissolved oxygen content of 0À05 atm. at 31.5‹ C. was maintained, as by periodic actuation of a 1 1. capacity electrolytic cell connected to a direct current stabilized power source of 5-15 volts; the production of 5-amino-4-imidazolecarboxamide-riboside by cultivation of Bacillus megaterium ATCC 15117 on a specified culture medium containing glucose and ribonucleic acid (dissolved oxygen=0À02 atm. at 34‹ C.); the production of inosine by cultivation of Bacillus subtilis ATCC 13952 on a specified culture medium containing glucose and adenine (dissolved oxygen=0À06 atm. at 31‹ C.); and the production of L-glutamic acid by cultivation of Corynebacterium hydrocarboclastus ATCC 15110 on specified n-alkane containing culture media (dissolved oxygen partial pressure=0À06 atm. or partial pressure of oxygen in the gas phase= 0À6 atm. at 30‹ C.).
GB361268A 1967-02-06 1968-01-23 Fermentation processes and apparatus for Carrying Out the same Expired GB1153114A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP720267 1967-02-06

Publications (1)

Publication Number Publication Date
GB1153114A true GB1153114A (en) 1969-05-21

Family

ID=11659427

Family Applications (1)

Application Number Title Priority Date Filing Date
GB361268A Expired GB1153114A (en) 1967-02-06 1968-01-23 Fermentation processes and apparatus for Carrying Out the same

Country Status (2)

Country Link
FR (1) FR1554216A (en)
GB (1) GB1153114A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103627636A (en) * 2013-12-04 2014-03-12 湖北民族学院 Airlift type magnetic anion bioreactor
JP2015500030A (en) * 2011-12-06 2015-01-05 セラピューティック プロテインズ インターナショナル， エルエルシー Closed bioreactor
CN111662138A (en) * 2020-06-19 2020-09-15 广东石油化工学院 Method and device for aerobic humification of livestock and poultry breeding manure

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549851A1 (en) * 1983-07-29 1985-02-01 Gradient Ass Loi 1901 Device permitting the regulation of dissolved gas concentrations in fermentation
DE3786213T2 (en) * 1986-09-19 1993-09-30 Shimadzu Corp Pressure incubator.

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015500030A (en) * 2011-12-06 2015-01-05 セラピューティック プロテインズ インターナショナル， エルエルシー Closed bioreactor
EP2788470A4 (en) * 2011-12-06 2015-10-14 Therapeutic Proteins Int Llc Closed bioreactors
CN103627636A (en) * 2013-12-04 2014-03-12 湖北民族学院 Airlift type magnetic anion bioreactor
CN103627636B (en) * 2013-12-04 2015-03-25 湖北民族学院 Airlift type magnetic anion bioreactor
CN111662138A (en) * 2020-06-19 2020-09-15 广东石油化工学院 Method and device for aerobic humification of livestock and poultry breeding manure

Also Published As

Publication number Publication date
FR1554216A (en) 1969-01-17

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees