GB1148123A - 3-substituted amino-1,2,3,4-tetrahydrocarbazoles - Google Patents
3-substituted amino-1,2,3,4-tetrahydrocarbazolesInfo
- Publication number
- GB1148123A GB1148123A GB1257767A GB1257767A GB1148123A GB 1148123 A GB1148123 A GB 1148123A GB 1257767 A GB1257767 A GB 1257767A GB 1257767 A GB1257767 A GB 1257767A GB 1148123 A GB1148123 A GB 1148123A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- alkyl
- hydrogen
- march
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Meat, Egg Or Seafood Products (AREA)
Abstract
1,148,123. Aminotetrahydrocarbazoles. MILES LABORATORIES Inc. 17 March, 1967 [25 March, 1966], No. 12577/67. Heading C2C. Novel compounds of formula (wherein R is C 1-4 alkyl, R 1 is hydrogen or C 1-4 alkyl, or NRR 1 is a monocyclic heterocyclic radical containing one or two N, O or S atoms, at least one of the hetero atoms being nitrogen, R 2 is hydrogen or C 1-4 alkyl, and R 3 is hydrogen, hydroxy, or C 1-4 alkoxy) and acid addition salts thereof, are prepared by cyclizing with heat or an acidic reagent a substituted phenylhydrazone of formula and, if desired, salifying the resulting base of Formula I. Compounds of Formula II are prepared by condensing the appropriate phenylhydrazine with the appropriate p-amino-cyclohexanone. 4-Methylaminocyclohexanone is obtained by oxidation of 4-methylaminocyclohexanol, itself obtained by hydrogenation of p-methylaminophenol sulphate. Analgesic compositions in unit dosage form comprise a base of Formula I or acceptable salt thereof (e.g. hydrochloride, hydrobromide, maleate, oxalate) in conjunction with an acceptable carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53729366A | 1966-03-25 | 1966-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1148123A true GB1148123A (en) | 1969-04-10 |
Family
ID=24142044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1257767A Expired GB1148123A (en) | 1966-03-25 | 1967-03-17 | 3-substituted amino-1,2,3,4-tetrahydrocarbazoles |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT272335B (en) |
| BE (1) | BE696061A (en) |
| CH (1) | CH511842A (en) |
| DE (1) | DE1695399B2 (en) |
| DK (1) | DK114623B (en) |
| ES (1) | ES338416A1 (en) |
| FI (1) | FI48732C (en) |
| FR (1) | FR1515629A (en) |
| GB (1) | GB1148123A (en) |
| NL (1) | NL151073B (en) |
| NO (1) | NO122123B (en) |
| SE (1) | SE327400B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2311547T3 (en) | 2000-08-16 | 2009-02-16 | F. Hoffmann-La Roche Ag | DERIVATIVES OF AMINOCICLOHEXANO. |
| US7012077B2 (en) | 2001-12-20 | 2006-03-14 | Hoffmann-La Roche Inc. | Substituted cyclohexane derivatives |
-
1967
- 1967-03-16 NO NO16730967A patent/NO122123B/no unknown
- 1967-03-17 GB GB1257767A patent/GB1148123A/en not_active Expired
- 1967-03-20 CH CH395567A patent/CH511842A/en not_active IP Right Cessation
- 1967-03-21 DK DK147767A patent/DK114623B/en unknown
- 1967-03-21 SE SE395667A patent/SE327400B/xx unknown
- 1967-03-21 FI FI83567A patent/FI48732C/en active
- 1967-03-21 NL NL6704176A patent/NL151073B/en unknown
- 1967-03-23 ES ES338416A patent/ES338416A1/en not_active Expired
- 1967-03-23 DE DE1967M0073307 patent/DE1695399B2/en active Granted
- 1967-03-23 AT AT285267A patent/AT272335B/en active
- 1967-03-24 FR FR100340A patent/FR1515629A/en not_active Expired
- 1967-03-24 BE BE696061D patent/BE696061A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES338416A1 (en) | 1968-04-01 |
| DK114623B (en) | 1969-07-21 |
| CH511842A (en) | 1971-08-31 |
| DE1695399A1 (en) | 1971-03-18 |
| FI48732B (en) | 1974-09-02 |
| SE327400B (en) | 1970-08-24 |
| BE696061A (en) | 1967-09-01 |
| FR1515629A (en) | 1968-03-01 |
| AT272335B (en) | 1969-07-10 |
| DE1695399B2 (en) | 1976-09-30 |
| NO122123B (en) | 1971-05-24 |
| NL151073B (en) | 1976-10-15 |
| NL6704176A (en) | 1967-09-26 |
| FI48732C (en) | 1974-12-10 |
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