ES338416A1 - 3-substituted amino-1,2,3,4-tetrahydrocarbazoles - Google Patents
3-substituted amino-1,2,3,4-tetrahydrocarbazolesInfo
- Publication number
- ES338416A1 ES338416A1 ES338416A ES338416A ES338416A1 ES 338416 A1 ES338416 A1 ES 338416A1 ES 338416 A ES338416 A ES 338416A ES 338416 A ES338416 A ES 338416A ES 338416 A1 ES338416 A1 ES 338416A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- alkyl
- hydrogen
- prepared
- appropriate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Novel compounds of formula (wherein R is C 1-4 alkyl, R 1 is hydrogen or C 1-4 alkyl, or NRR 1 is a monocyclic heterocyclic radical containing one or two N, O or S atoms, at least one of the hetero atoms being nitrogen, R 2 is hydrogen or C 1-4 alkyl, and R 3 is hydrogen, hydroxy, or C 1-4 alkoxy) and acid addition salts thereof, are prepared by cyclizing with heat or an acidic reagent a substituted phenylhydrazone of formula and, if desired, salifying the resulting base of Formula I. Compounds of Formula II are prepared by condensing the appropriate phenylhydrazine with the appropriate p-amino-cyclohexanone. 4-Methylaminocyclohexanone is obtained by oxidation of 4-methylaminocyclohexanol, itself obtained by hydrogenation of p-methylaminophenol sulphate. Analgesic compositions in unit dosage form comprise a base of Formula I or acceptable salt thereof (e.g. hydrochloride, hydrobromide, maleate, oxalate) in conjunction with an acceptable carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53729366A | 1966-03-25 | 1966-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES338416A1 true ES338416A1 (en) | 1968-04-01 |
Family
ID=24142044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES338416A Expired ES338416A1 (en) | 1966-03-25 | 1967-03-23 | 3-substituted amino-1,2,3,4-tetrahydrocarbazoles |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT272335B (en) |
| BE (1) | BE696061A (en) |
| CH (1) | CH511842A (en) |
| DE (1) | DE1695399B2 (en) |
| DK (1) | DK114623B (en) |
| ES (1) | ES338416A1 (en) |
| FI (1) | FI48732C (en) |
| FR (1) | FR1515629A (en) |
| GB (1) | GB1148123A (en) |
| NL (1) | NL151073B (en) |
| NO (1) | NO122123B (en) |
| SE (1) | SE327400B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100566175B1 (en) | 2000-08-16 | 2006-03-29 | 에프. 호프만-라 로슈 아게 | Novel aminocyclohexane derivatives |
| US7012077B2 (en) | 2001-12-20 | 2006-03-14 | Hoffmann-La Roche Inc. | Substituted cyclohexane derivatives |
-
1967
- 1967-03-16 NO NO16730967A patent/NO122123B/no unknown
- 1967-03-17 GB GB1257767A patent/GB1148123A/en not_active Expired
- 1967-03-20 CH CH395567A patent/CH511842A/en not_active IP Right Cessation
- 1967-03-21 SE SE395667A patent/SE327400B/xx unknown
- 1967-03-21 NL NL6704176A patent/NL151073B/en unknown
- 1967-03-21 DK DK147767A patent/DK114623B/en unknown
- 1967-03-21 FI FI83567A patent/FI48732C/en active
- 1967-03-23 ES ES338416A patent/ES338416A1/en not_active Expired
- 1967-03-23 DE DE1967M0073307 patent/DE1695399B2/en active Granted
- 1967-03-23 AT AT285267A patent/AT272335B/en active
- 1967-03-24 FR FR100340A patent/FR1515629A/en not_active Expired
- 1967-03-24 BE BE696061D patent/BE696061A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR1515629A (en) | 1968-03-01 |
| DK114623B (en) | 1969-07-21 |
| DE1695399A1 (en) | 1971-03-18 |
| SE327400B (en) | 1970-08-24 |
| NO122123B (en) | 1971-05-24 |
| FI48732C (en) | 1974-12-10 |
| NL151073B (en) | 1976-10-15 |
| CH511842A (en) | 1971-08-31 |
| BE696061A (en) | 1967-09-01 |
| AT272335B (en) | 1969-07-10 |
| NL6704176A (en) | 1967-09-26 |
| FI48732B (en) | 1974-09-02 |
| DE1695399B2 (en) | 1976-09-30 |
| GB1148123A (en) | 1969-04-10 |
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