GB1146992A - Improvements in or relating to novel steroids and the manufacture thereof - Google Patents
Improvements in or relating to novel steroids and the manufacture thereofInfo
- Publication number
- GB1146992A GB1146992A GB51277/68A GB5127768A GB1146992A GB 1146992 A GB1146992 A GB 1146992A GB 51277/68 A GB51277/68 A GB 51277/68A GB 5127768 A GB5127768 A GB 5127768A GB 1146992 A GB1146992 A GB 1146992A
- Authority
- GB
- United Kingdom
- Prior art keywords
- androsten
- hydroxy
- methyl
- androstenes
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 230000001590 oxidative effect Effects 0.000 abstract 2
- HFJJFVWDQNSUGH-VMXHOPILSA-N (8s,9s,10r,13s,14s)-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1h-cyclopenta[a]phenanthrene Chemical compound C1C=C2C=CCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 HFJJFVWDQNSUGH-VMXHOPILSA-N 0.000 abstract 1
- DTBTTYFYSGBQRB-UHFFFAOYSA-N 2-(3,4-dihydro-2h-pyran-2-yloxy)-3,4-dihydro-2h-pyran Chemical group O1C=CCCC1OC1OC=CCC1 DTBTTYFYSGBQRB-UHFFFAOYSA-N 0.000 abstract 1
- PDSSASWDTRRQKO-UHFFFAOYSA-N 3-(3,4-dihydro-2H-pyran-3-yloxy)-3,4-dihydro-2H-pyran Chemical compound O1CC(CC=C1)OC1COC=CC1 PDSSASWDTRRQKO-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 230000001195 anabolic effect Effects 0.000 abstract 1
- 230000001548 androgenic effect Effects 0.000 abstract 1
- 150000001443 androstenes Chemical class 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- -1 hydrocarbon carboxylic acid Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00446395A US3846456A (en) | 1965-04-07 | 1965-04-07 | Organic compounds |
| US446396A US3380886A (en) | 1965-04-07 | 1965-04-07 | 7alpha-methyl-3beta-hydroxy-5-androstenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1146992A true GB1146992A (en) | 1969-03-26 |
Family
ID=27034609
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB51277/68A Expired GB1146992A (en) | 1965-04-07 | 1966-04-06 | Improvements in or relating to novel steroids and the manufacture thereof |
| GB15371/66A Expired GB1146053A (en) | 1965-04-07 | 1966-04-06 | Improvements in or relating to novel steroids and the manufacture thereof |
| GB15372/66A Expired GB1146991A (en) | 1965-04-07 | 1966-04-06 | Improvements in or relating to novel steroids and the manufacture thereof |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15371/66A Expired GB1146053A (en) | 1965-04-07 | 1966-04-06 | Improvements in or relating to novel steroids and the manufacture thereof |
| GB15372/66A Expired GB1146991A (en) | 1965-04-07 | 1966-04-06 | Improvements in or relating to novel steroids and the manufacture thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3380886A (enExample) |
| BE (2) | BE679215A (enExample) |
| CH (2) | CH507224A (enExample) |
| DE (1) | DE1593621A1 (enExample) |
| FR (2) | FR5794M (enExample) |
| GB (3) | GB1146992A (enExample) |
| IL (2) | IL25391A (enExample) |
| NL (2) | NL6604607A (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7501563A (nl) * | 1974-02-28 | 1975-09-01 | Merck & Co Inc | Werkwijze voor het bereiden van preparaten te- gen het samenpakken van bloedplaatjes. |
| US4297350A (en) * | 1978-10-10 | 1981-10-27 | The Upjohn Company | Male contraceptive steroids and methods of use |
| US4898694A (en) * | 1987-11-25 | 1990-02-06 | Schwartz Arthur G | 17-Hydroxy-steroids |
| US5227375A (en) * | 1990-02-08 | 1993-07-13 | Endorecherche, Inc. | Aromatase inhibitors |
| IT1277700B1 (it) * | 1995-12-22 | 1997-11-11 | Poli Ind Chimica Spa | Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura |
| US6667299B1 (en) * | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
| WO2002028880A2 (en) * | 2000-10-06 | 2002-04-11 | Aeson Therapeutics Inc. | Compounds useful for treating hypertriglyceridemia |
| CN113613658A (zh) * | 2019-02-28 | 2021-11-05 | 普渡研究基金会 | 用于去势抵抗性前列腺癌靶向疗法的化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3262949A (en) * | 1956-11-13 | 1966-07-26 | Syntex Corp | 7-methyl androstane compounds |
| US3145221A (en) * | 1957-11-27 | 1964-08-18 | Syntex Corp | 17alpha-lower alkyl, 17alpha-lower alkinyl and 17alpha-lower alkenyl derivatives of 19-nor-delta5-androsten-17beta-ol-3-one |
| US3029263A (en) * | 1959-12-24 | 1962-04-10 | Upjohn Co | 7-methyl-4, 6-androstadienes |
| US3246021A (en) * | 1960-04-20 | 1966-04-12 | Merck & Co Inc | Intermediates in the preparation of 6beta-methyl-halo ethisterone compounds |
| DE1249264B (de) * | 1962-08-24 | 1967-09-07 | The British Drug Houses Limited London | Verfahren zur Her Stellung von neuen YIi Chlorathmyl 17ß alkoxysteroiden |
-
1965
- 1965-04-07 US US446396A patent/US3380886A/en not_active Expired - Lifetime
-
1966
- 1966-03-15 IL IL25391A patent/IL25391A/xx unknown
- 1966-03-16 IL IL25403A patent/IL25403A/xx unknown
- 1966-03-18 CH CH391566A patent/CH507224A/de not_active IP Right Cessation
- 1966-04-06 GB GB51277/68A patent/GB1146992A/en not_active Expired
- 1966-04-06 NL NL6604607A patent/NL6604607A/xx unknown
- 1966-04-06 GB GB15371/66A patent/GB1146053A/en not_active Expired
- 1966-04-06 GB GB15372/66A patent/GB1146991A/en not_active Expired
- 1966-04-06 DE DE19661593621 patent/DE1593621A1/de active Pending
- 1966-04-06 NL NL6604606A patent/NL6604606A/xx unknown
- 1966-04-07 BE BE679215D patent/BE679215A/xx unknown
- 1966-04-07 BE BE679218D patent/BE679218A/xx unknown
- 1966-07-05 FR FR68275A patent/FR5794M/fr not_active Expired
- 1966-07-05 FR FR68276A patent/FR5612M/fr not_active Expired
-
1968
- 1968-03-25 CH CH433166A patent/CH490359A/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE679215A (enExample) | 1966-10-07 |
| NL6604606A (enExample) | 1966-10-10 |
| GB1146053A (en) | 1969-03-19 |
| DE1593613B2 (de) | 1976-01-15 |
| IL25403A (en) | 1970-07-19 |
| GB1146991A (en) | 1969-03-26 |
| IL25391A (en) | 1970-01-29 |
| US3380886A (en) | 1968-04-30 |
| FR5794M (enExample) | 1968-02-12 |
| CH490359A (de) | 1970-05-15 |
| CH507224A (de) | 1971-05-15 |
| NL6604607A (enExample) | 1966-10-10 |
| DE1593613A1 (de) | 1970-08-13 |
| DE1593621A1 (de) | 1970-05-27 |
| BE679218A (enExample) | 1966-10-07 |
| FR5612M (enExample) | 1967-12-11 |
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