GB1142029A - Optically active substituted piperidines and process for their manufacture - Google Patents
Optically active substituted piperidines and process for their manufactureInfo
- Publication number
- GB1142029A GB1142029A GB2642366A GB2642366A GB1142029A GB 1142029 A GB1142029 A GB 1142029A GB 2642366 A GB2642366 A GB 2642366A GB 2642366 A GB2642366 A GB 2642366A GB 1142029 A GB1142029 A GB 1142029A
- Authority
- GB
- United Kingdom
- Prior art keywords
- optically active
- phenyl
- substituted
- piperidine
- substituted piperidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1,142,029. Substituted piperidines. CIBA Ltd. 14 June, 1966 [14 June, 1965], No. 26423/66. Heading C2C. Novel substituted piperidines of the general formula wherein Ph 1 and Ph 2 each stands for a phenyl, lower alkyl-phenyl, lower alkoxy-phenyl or halo-phenyl group and X stands for a hydroxy group or a halogen atom, especially a chlorine atom, and acid addition salts thereof, are prepared by (a) resolving the racemic substituted piperidine with an optically active acid, (b) replacing the amino group in an optically active 1.(#-aminoetbyl) substituted piperidine by a hydroxyl group or a halogen atom, (c) adding water or a hydrohalide to an optically active 1-vinyl substituted piperidine, and (d) reacting an optically active N-unsubstituted piperidine with ethylene oxide or a reactive monoester of ethylene glycol; followed by optional saltformation. Pharmaceutical compositions having gastric secretion inhibiting, antitremorine and stimulating activity comprise as active ingredient a substituted piperidine of the above general formula or a physiologically tolerable acid addition salt thereof and a pharmaceutically suitable carrier.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46384865A | 1965-06-14 | 1965-06-14 | |
| US53109466A | 1966-03-02 | 1966-03-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1142029A true GB1142029A (en) | 1969-02-05 |
Family
ID=27040762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2642366A Expired GB1142029A (en) | 1965-06-14 | 1966-06-14 | Optically active substituted piperidines and process for their manufacture |
Country Status (5)
| Country | Link |
|---|---|
| AT (2) | AT265267B (en) |
| BE (1) | BE682430A (en) |
| ES (1) | ES327880A1 (en) |
| GB (1) | GB1142029A (en) |
| NL (1) | NL6608186A (en) |
-
1966
- 1966-06-13 ES ES0327880A patent/ES327880A1/en not_active Expired
- 1966-06-13 NL NL6608186A patent/NL6608186A/xx unknown
- 1966-06-13 BE BE682430D patent/BE682430A/xx unknown
- 1966-06-13 AT AT948867A patent/AT265267B/en active
- 1966-06-13 AT AT948567A patent/AT265264B/en active
- 1966-06-14 GB GB2642366A patent/GB1142029A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES327880A1 (en) | 1967-08-01 |
| BE682430A (en) | 1966-12-13 |
| NL6608186A (en) | 1966-12-15 |
| AT265267B (en) | 1968-10-10 |
| AT265264B (en) | 1968-10-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1464326A (en) | Benzimidazole carbamates | |
| GB1111451A (en) | Improvements in or relating to pharmacologically-active secondary amine compounds | |
| GB1285400A (en) | Esters of substituted anthranilic acid | |
| GB1411149A (en) | Blood lipid level-controlling and anti-coagulant drugs | |
| GB1142029A (en) | Optically active substituted piperidines and process for their manufacture | |
| GB1176757A (en) | Quinuclidine Carboxylic Acid Amides | |
| ES474733A1 (en) | Pseudomonic acid C, pharmaceutically acceptable salts or esters thereof, processes for their preparation and pharmaceutical or veterinary compositions containing them. | |
| GB1394757A (en) | Lysino-calcium chloride | |
| GB1156781A (en) | New Heterocyclic Compounds | |
| GB1433472A (en) | Biphenylyl ethers and their preparation | |
| GB1431712A (en) | Benzomorphan derivatives | |
| GB1195319A (en) | Alkyl Sulfate Salts of 1-(p-Chlorobenzhydryl)-4-Methylhomopiperazines | |
| GB1426541A (en) | Cephalosporanic derivatives process for their preparation and compositions incorporating them | |
| GB1318479A (en) | N-bicycloamino-alkanoyl-anilines | |
| GB1418831A (en) | Reserpine derivatives | |
| GB1192127A (en) | New Benzhydryl Ethers and process for their preparation | |
| GB1299289A (en) | Piperidine derivatives | |
| ES8503336A1 (en) | Peripheral opiate antagonists, process for their preparation and pharmaceutical compositions containing them. | |
| GB1199040A (en) | Diisoeugenol Derivatives | |
| GB1382559A (en) | N-substituted piperazines and process for the production thereof | |
| GB1409990A (en) | Ester with a vaso-dilating spasmolytic and hypolipemiant action | |
| GB1366683A (en) | Substituted tetrahydroquinolines | |
| GB1397697A (en) | Phenoxyalicyclic carboxylic acid derivatives methods of making them and compositions containing them | |
| GB1121763A (en) | Novel n-substituted piperidine derivatives | |
| GB1285266A (en) | Pyrimidinyl thiopseudoureas and their preparation |