ES327880A1 - Procedure for obtaining optically active piperidines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

"Procedure for obtaining optically active piperidines", characterized in that a) a mixture of diastereomeric forms of salts of a racemic 1- (β -hydroxy- or halo-ethyl) -diphenylmethyl-piperidine is separated with an antipode of an optically active acid, and one or both of the diastereomeric salts is isolated, or b) in an optically active 1 - (β R-ethyl) -diphenylmethyl-piperidine, in which R means a transformable radical in a hydroxy radical or in a halogen atom, this radical is converted to the hydroxy radical or to a halogen atom, or c) an optically active 1-vinyl-diphenylmethylpiperidine is added water or a hydrogen halide, or d) an optically active, N-unsubstituted diphenylmethylmethylpiperidine is reacted with ethylenic oxide or an ester capable of reacting ethylene glycol, or e) in a 1 - (β -hydroxy- or halogeno-ethyl) -diphenylmethyl-piperidine, optically active, which in the ring and/or ethyl chain shows a carbamyl radical or a double bond, this radical is reduced to the methyleneimino radical or to a simple link, or f) in an optically active 1-carboxymethyl diphenylmethylpiperidine, the carboxy radical is reduced to the hydroxymethyl radical, and if desired, an optically active 1 - (β -hydroxy-ethyl) -diphenylmetol-piperidine, obtained it is transformed into the corresponding β -halogen-ethyl compound, and/or an optically active salt obtained is transformed into the corresponding base or other salt, or an optically active base in its salt. (Machine-translation by Google Translate, not legally binding)