GB1128303A - Method of and apparatus for washing blood or other biological cells - Google Patents

Method of and apparatus for washing blood or other biological cells

Info

Publication number
GB1128303A
GB1128303A GB4022/66A GB402266A GB1128303A GB 1128303 A GB1128303 A GB 1128303A GB 4022/66 A GB4022/66 A GB 4022/66A GB 402266 A GB402266 A GB 402266A GB 1128303 A GB1128303 A GB 1128303A
Authority
GB
United Kingdom
Prior art keywords
tube
cells
sterilized
tubes
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4022/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IVAN SORVALL Inc
Original Assignee
IVAN SORVALL Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IVAN SORVALL Inc filed Critical IVAN SORVALL Inc
Publication of GB1128303A publication Critical patent/GB1128303A/en
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3692—Washing or rinsing blood or blood constituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Centrifugal Separators (AREA)
  • External Artificial Organs (AREA)

Abstract

1,128,303. Centrifugal separators. IVAN SORVALL, Inc. 28 Jan., 1966 [3 Feb., 1965], No. 4022/66. Heading B2P. Biological, e.g. blood, cells are washed by mixing a suspension of the cells with a washing solution having a density less than that of the cells, subjecting the mixture to a centrifuging action thereby providing a counterflow between the cells and the washing solution and removing from the mixture effluent produced during centrifuging. Blood and saline washing solution are continuously drawn by means of a pump 31 respectively from a sterilized plastic bag 21 and a sterilized storage bottle 22, Fig. 1, through a junction fitting 33 where they are mixed and the mixture is delivered via a tube 29, a flow meter 34, tubes 36, 37, 38 and a rotary joint to radially and downwardly extending tubes 44 in a continuous flow centrifuge 39 which is housed in a temperaturecontrolled chamber 47. Each tube 44, Fig. 2, is provided with an inlet tube 48, for the supply of the mixture, and an outlet tube 49, for the removal of effluent, which extend through a compression element 51 closing the tube 44. The tubes 48 and 49 of all tubes 44 are connected respectively to a common inlet and a common outlet manifold (not shown). Each tube 48 is constricted at its outlet end to form one or two terminal ports 57 and is provided along its length with ports 58 which distribute the incoming mixture to spacedapart regions of the tube 44 having different values of centrifugal acoeleration. During centrifugation, the heavier blood cells move outwardly and downwardly in each tube 44, while the lighter washing solution moves in a counterflow direction inwardly and upwardly and emerges as an effluent through outlet tube 49 to be continuously discharged to waste via tubes 41, 42, 43. After completion of a washing operation, each tube 44 is removed from the centrifuge. An air filter 61 is attached by a sterilized tube 62 to the tube 48 and a hollow sterilized needle 63 is connected by a sterilized tube 66 to the tube 49. The tube 44 is then clamped in a support pedestal 67 and the needle 63 is caused to pierce a resilient cap 68 in a storage bottle 59. Transfer of the washed blood cells from the tube 44 to the bottle 59 then takes place by gravity.
GB4022/66A 1965-02-03 1966-01-28 Method of and apparatus for washing blood or other biological cells Expired GB1128303A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43011865A 1965-02-03 1965-02-03

Publications (1)

Publication Number Publication Date
GB1128303A true GB1128303A (en) 1968-09-25

Family

ID=23706138

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4022/66A Expired GB1128303A (en) 1965-02-03 1966-01-28 Method of and apparatus for washing blood or other biological cells

Country Status (3)

Country Link
US (1) US3452924A (en)
DE (1) DE1617782C3 (en)
GB (1) GB1128303A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113000230A (en) * 2021-02-24 2021-06-22 安徽中科中佳科学仪器有限公司 Laboratory medical centrifuge of disinfection automatically cleaning disinfects

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3977598A (en) * 1973-05-24 1976-08-31 Mcdonald Bernard Centrifuge tube
US3982691A (en) * 1974-10-09 1976-09-28 Schlutz Charles A Centrifuge separation and washing device and method
US4056224A (en) * 1975-03-27 1977-11-01 Baxter Travenol Laboratories, Inc. Flow system for centrifugal liquid processing apparatus
US4069968A (en) * 1976-11-01 1978-01-24 Union Carbide Corporation Disposable tubing harness for use with blood washing apparatus
US4049192A (en) * 1976-11-01 1977-09-20 Union Carbide Corporation Blood washing method using a saline wash solution of varying concentration for use with blood washing apparatus
US4135883A (en) * 1977-08-29 1979-01-23 Bio-Dynamics Inc. Blood analyzer system
US4435293A (en) * 1981-08-05 1984-03-06 Ortho Diagnostic Systems Inc. Particle washing system and method of use
US4648863A (en) * 1984-02-07 1987-03-10 Edmund Buhler Apparatus for the pure preparation of particles, biological cell systems and colloids
USRE33924E (en) * 1986-07-16 1992-05-12 Autologous Blood Corp. Apparatus and method for storing and processing blood
US4804363A (en) * 1986-07-16 1989-02-14 Autologous Blood Corporation Apparatus and method for storing and processing blood
US5704888A (en) * 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Intermittent collection of mononuclear cells in a centrifuge apparatus
US5704889A (en) * 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus
DE69819689T2 (en) 1997-02-14 2004-09-23 Dendreon Corp., Seattle METHOD AND DEVICE FOR WASHING CELLS
US20070118063A1 (en) * 2005-10-05 2007-05-24 Gambro, Inc Method and Apparatus for Leukoreduction of Red Blood Cells
US8016736B2 (en) * 2006-10-20 2011-09-13 Caridianbct Biotechnologies, Llc Methods for washing a red blood cell component and for removing prions therefrom
US20080147240A1 (en) * 2006-12-19 2008-06-19 Gambro Bct Inc. Apparatus for separating a composite liquid with process control on a centrifuge rotor
JP2010148450A (en) * 2008-12-25 2010-07-08 Olympus Corp Method for cleaning cell
US20100291534A1 (en) * 2009-05-12 2010-11-18 National Central University Methods and Systems for Isolating, Ex Vivo Expanding and Harvesting Hematopoietic Stem Cells
CN113444628B (en) * 2021-05-28 2022-04-15 电子科技大学 Tissue block cleaning device and cleaning method thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2775240A (en) * 1953-02-09 1956-12-25 Abbott Lab Gas valve
US2758597A (en) * 1955-01-24 1956-08-14 Cutter Lab Blood transfusion apparatus
US2834541A (en) * 1956-09-20 1958-05-13 Sorvall Inc Ivan Centrifuging apparatus and system
GB864410A (en) * 1958-04-15 1961-04-06 Sorvall Inc Ivan Continuous centrifuge
US3092106A (en) * 1958-08-04 1963-06-04 Cutter Lab Administration equipment
US3064646A (en) * 1958-10-15 1962-11-20 Galen L Miller Breathing apparatus
US3050238A (en) * 1959-03-02 1962-08-21 Dresser Ind Liquid feed arrangement for centrifugal devices
US3133880A (en) * 1959-12-21 1964-05-19 Vernon D Jarvis Centrifugal extractor
US3235173A (en) * 1960-07-28 1966-02-15 Unger Hans Peter Olof Agitating and/or fractioning centrifuge
US3185154A (en) * 1962-08-14 1965-05-25 Joseph F Caccavo Apparatus for collecting, separating, storing and dispensing whole blood
US3347454A (en) * 1964-05-13 1967-10-17 Baxter Laboratories Inc Method and apparatus for the centrifugal washing of particles in a closed system

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113000230A (en) * 2021-02-24 2021-06-22 安徽中科中佳科学仪器有限公司 Laboratory medical centrifuge of disinfection automatically cleaning disinfects

Also Published As

Publication number Publication date
DE1617782A1 (en) 1971-04-08
US3452924A (en) 1969-07-01
DE1617782B2 (en) 1973-02-22
DE1617782C3 (en) 1973-09-13

Similar Documents

Publication Publication Date Title
GB1128303A (en) Method of and apparatus for washing blood or other biological cells
AU691719B2 (en) Centrifuge with annular filter
US5824230A (en) Method and device for separating a component such as fibrin I from blood plasma
GB726596A (en) Improvements in or relating to centrifuges for separating, sludge containing liquids
GB1212414A (en) Flexible bag for particle washing purposes
SE8703562L (en) SETTING AND DEVICE CLEANING BLOOD CELLS
GB888304A (en) Improvements in high efficiency screen
US3474955A (en) Apparatus for extraction by centrifugation of the oil contained in an olive cake
KR910004881A (en) Apparatus for the production and distribution of dye solution in dyeing factories
CN109294869B (en) Bag filter, fat extraction system and operation method thereof
GB999938A (en) Apparatus for centrifugally separating suspended particles from gas
GB1028831A (en) Centrifuge for separating solids from liquids
GB756198A (en) Method and apparatus for separating mixtures of solid materials in a heavy medium
SE8306477D0 (en) CYCLE TYPE CLEANING DEVICE
GB1276884A (en) A centrifuge
SE8306892D0 (en) PROCEDURE AND APPARATUS FOR DIFFERENTIATION OF INGREDIENTS IN A MIXTURE
SU1123726A1 (en) Blood processing device
CN209108705U (en) A kind of bag filter and the filtration system using the filter
JPS55139851A (en) Centrifugal spiral separator
JPS57197004A (en) Bubble separating apparatus
KR101940773B1 (en) Kit for extracting device of regenerative cells
CN107383216B (en) Starch refining device with pre-concentration rotational flow system and production process thereof
GB832255A (en) Improvements in or relating to centrifugal separators
GB828361A (en) Apparatus for concentrating and feeding a liquid slurry of polymeric particles to a screw extruder
GB307933A (en) Improvements in or relating to the centrifugal cleaning of liquids