GB1127672A - Benzenesulphonyl-ureas and process for their manufacture - Google Patents
Benzenesulphonyl-ureas and process for their manufactureInfo
- Publication number
- GB1127672A GB1127672A GB13149/66A GB1314966A GB1127672A GB 1127672 A GB1127672 A GB 1127672A GB 13149/66 A GB13149/66 A GB 13149/66A GB 1314966 A GB1314966 A GB 1314966A GB 1127672 A GB1127672 A GB 1127672A
- Authority
- GB
- United Kingdom
- Prior art keywords
- urea
- benzenesulphonyl
- alkyl
- cyclohexyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 10
- 235000013877 carbamide Nutrition 0.000 abstract 6
- -1 Benzene-sulphonyl ureas Chemical class 0.000 abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 239000004202 carbamide Chemical class 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000004820 halides Chemical class 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical class NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 abstract 2
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 abstract 1
- 101100037762 Caenorhabditis elegans rnh-2 gene Proteins 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- NNHSFBDNDJBVBD-UHFFFAOYSA-N benzenesulfinylurea Chemical class NC(=O)NS(=O)C1=CC=CC=C1 NNHSFBDNDJBVBD-UHFFFAOYSA-N 0.000 abstract 1
- CSKNSYBAZOQPLR-UHFFFAOYSA-N benzenesulfonyl chloride Chemical class ClS(=O)(=O)C1=CC=CC=C1 CSKNSYBAZOQPLR-UHFFFAOYSA-N 0.000 abstract 1
- PVMBGVAQRSHDBB-UHFFFAOYSA-N benzenesulfonylthiourea Chemical class NC(=S)NS(=O)(=O)C1=CC=CC=C1 PVMBGVAQRSHDBB-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- 229910000474 mercury oxide Inorganic materials 0.000 abstract 1
- UKWHYYKOEPRTIC-UHFFFAOYSA-N mercury(ii) oxide Chemical compound [Hg]=O UKWHYYKOEPRTIC-UHFFFAOYSA-N 0.000 abstract 1
- UJYAZVSPFMJCLW-UHFFFAOYSA-N n-(oxomethylidene)benzenesulfonamide Chemical class O=C=NS(=O)(=O)C1=CC=CC=C1 UJYAZVSPFMJCLW-UHFFFAOYSA-N 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- ZFLIKDUSUDBGCD-UHFFFAOYSA-N parabanic acid Chemical compound O=C1NC(=O)C(=O)N1 ZFLIKDUSUDBGCD-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- IGXIQOFPTUWHFL-UHFFFAOYSA-N phenylsulfanylurea Chemical class NC(=O)NSC1=CC=CC=C1 IGXIQOFPTUWHFL-UHFFFAOYSA-N 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
- 150000003672 ureas Chemical class 0.000 abstract 1
- 238000010792 warming Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Paper (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF0045611 | 1965-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1127672A true GB1127672A (en) | 1968-09-18 |
Family
ID=7100569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB13149/66A Expired GB1127672A (en) | 1965-03-24 | 1966-03-24 | Benzenesulphonyl-ureas and process for their manufacture |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3454636A (enExample) |
| JP (4) | JPS4939252B1 (enExample) |
| AT (5) | AT275545B (enExample) |
| BE (1) | BE678358A (enExample) |
| CH (2) | CH467756A (enExample) |
| DE (1) | DE1518816C3 (enExample) |
| FI (1) | FI45957C (enExample) |
| FR (2) | FR1552785A (enExample) |
| GB (1) | GB1127672A (enExample) |
| IL (1) | IL25351A (enExample) |
| NL (1) | NL6603879A (enExample) |
| NO (1) | NO123643B (enExample) |
| SE (1) | SE345262B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54135044U (enExample) * | 1978-03-11 | 1979-09-19 | ||
| JPS6184746U (enExample) * | 1984-11-07 | 1986-06-04 | ||
| DE19923086A1 (de) | 1999-05-20 | 2000-11-23 | Aventis Pharma Gmbh | Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10054481A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10054482A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1185180B (de) * | 1963-10-19 | 1965-01-14 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
-
1965
- 1965-03-24 DE DE1518816A patent/DE1518816C3/de not_active Expired
-
1966
- 1966-03-08 US US532567A patent/US3454636A/en not_active Expired - Lifetime
- 1966-03-09 IL IL25351A patent/IL25351A/en unknown
- 1966-03-21 CH CH1735568A patent/CH467756A/de unknown
- 1966-03-21 CH CH405566A patent/CH468357A/de unknown
- 1966-03-22 AT AT286468A patent/AT275545B/de active
- 1966-03-22 AT AT286668A patent/AT274837B/de active
- 1966-03-22 AT AT286368A patent/AT276427B/de active
- 1966-03-22 AT AT270966A patent/AT273987B/de active
- 1966-03-22 AT AT286568A patent/AT274836B/de active
- 1966-03-23 NO NO162257A patent/NO123643B/no unknown
- 1966-03-23 SE SE3812/66A patent/SE345262B/xx unknown
- 1966-03-23 FI FI660750A patent/FI45957C/fi active
- 1966-03-24 FR FR1552785D patent/FR1552785A/fr not_active Expired
- 1966-03-24 JP JP41018256A patent/JPS4939252B1/ja active Pending
- 1966-03-24 NL NL6603879A patent/NL6603879A/xx unknown
- 1966-03-24 BE BE678358D patent/BE678358A/xx unknown
- 1966-03-24 GB GB13149/66A patent/GB1127672A/en not_active Expired
- 1966-06-23 FR FR66654A patent/FR5625M/fr not_active Expired
-
1967
- 1967-08-22 JP JP42053925A patent/JPS4945392B1/ja active Pending
- 1967-08-22 JP JP42053924A patent/JPS4945391B1/ja active Pending
- 1967-08-22 JP JP42053923A patent/JPS4945390B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL25351A (en) | 1970-01-29 |
| JPS4939252B1 (enExample) | 1974-10-24 |
| AT276427B (de) | 1969-11-25 |
| JPS4945391B1 (enExample) | 1974-12-04 |
| FR5625M (enExample) | 1967-12-18 |
| CH468357A (de) | 1969-02-15 |
| NO123643B (enExample) | 1971-12-27 |
| FI45957C (fi) | 1972-11-10 |
| DE1518816C3 (de) | 1975-05-22 |
| BE678358A (enExample) | 1966-09-26 |
| AT274837B (de) | 1969-10-10 |
| NL6603879A (enExample) | 1966-09-26 |
| AT275545B (de) | 1969-10-27 |
| AT273987B (de) | 1969-09-10 |
| AT274836B (de) | 1969-10-10 |
| FR1552785A (enExample) | 1969-01-10 |
| DE1518816B2 (de) | 1974-09-19 |
| FI45957B (enExample) | 1972-07-31 |
| US3454636A (en) | 1969-07-08 |
| JPS4945390B1 (enExample) | 1974-12-04 |
| SE345262B (enExample) | 1972-05-23 |
| CH467756A (de) | 1969-01-31 |
| DE1518816A1 (de) | 1969-04-30 |
| JPS4945392B1 (enExample) | 1974-12-04 |
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