GB1124453A - N-pentanol piperazine and its acid addition salts and process for preparation thereof - Google Patents

N-pentanol piperazine and its acid addition salts and process for preparation thereof

Info

Publication number
GB1124453A
GB1124453A GB4509465A GB4509465A GB1124453A GB 1124453 A GB1124453 A GB 1124453A GB 4509465 A GB4509465 A GB 4509465A GB 4509465 A GB4509465 A GB 4509465A GB 1124453 A GB1124453 A GB 1124453A
Authority
GB
United Kingdom
Prior art keywords
piperazine
addition salts
acid addition
pentanol
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4509465A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA
Original Assignee
Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA filed Critical Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA
Publication of GB1124453A publication Critical patent/GB1124453A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The novel compounds N-(5-hydroxypentyl) piperazine and its acid addition salts with organic and inorganic acids are prepared by reaction of a tetrahydro pyran of formula <FORM:1124453/C2/1> wherein R is OH or di-(C1- 4) alkylamino and a piperazine which has a hydrogen atom attached to one nitrogen atom and is of one of the formulae <FORM:1124453/C2/2> and <FORM:1124453/C2/3> wherein A is benzoyl or carbethoxy and A1 is an inorganic acid followed by reduction of the N - (tetrahydropyranyl - 2) piperazine derivative so formed and elimination of A1 or replacement of A by H, by standard methods, followed by salt formation if desired.
GB4509465A 1964-10-26 1965-10-25 N-pentanol piperazine and its acid addition salts and process for preparation thereof Expired GB1124453A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR75992627 1964-10-26
FR75022035 1965-06-24

Publications (1)

Publication Number Publication Date
GB1124453A true GB1124453A (en) 1968-08-21

Family

ID=26235572

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4509465A Expired GB1124453A (en) 1964-10-26 1965-10-25 N-pentanol piperazine and its acid addition salts and process for preparation thereof

Country Status (2)

Country Link
FR (1) FR88351E (en)
GB (1) GB1124453A (en)

Also Published As

Publication number Publication date
FR88351E (en) 1967-01-27

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