GB1123954A - Aryl carbinols - Google Patents

Aryl carbinols

Info

Publication number
GB1123954A
GB1123954A GB21527/66A GB2152766A GB1123954A GB 1123954 A GB1123954 A GB 1123954A GB 21527/66 A GB21527/66 A GB 21527/66A GB 2152766 A GB2152766 A GB 2152766A GB 1123954 A GB1123954 A GB 1123954A
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
group
c6h5cr
r3ch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB21527/66A
Inventor
David Miller
Bryn Owen Hughes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB21527/66A priority Critical patent/GB1123954A/en
Priority to IL2791567A priority patent/IL27915A/en
Priority to FI131467A priority patent/FI44229C/en
Priority to DE19671618154 priority patent/DE1618154A1/en
Priority to NL6706503A priority patent/NL6706503A/xx
Priority to NO16808367A priority patent/NO116077B/no
Priority to AT441767A priority patent/AT273927B/en
Priority to DK252567A priority patent/DK121603B/en
Priority to CH676367A priority patent/CH475942A/en
Priority to FR106201A priority patent/FR6469M/fr
Priority to BE698465D priority patent/BE698465A/xx
Priority to ES340554A priority patent/ES340554A1/en
Publication of GB1123954A publication Critical patent/GB1123954A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Rotary Pumps (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds of the general Formula (I) C6H5CR(OH)CH2NR1R2 (wherein R is a propargyl group or a group R3CH: CH- or R3C : C-, in which R3 is a hydrogen atom or a C1- 6 alkyl group, and R1 and R2 are the same or different, and are each a hydrogen atom, a C1- 6 alkyl group or an aralkyl group) and their acid addition salts, are prepared by (a) reacting a compound of the Formula (II) C6H5CR(OH)CH2Cl with R1R2NH or (b) converting the compound of Formula (II) to an epoxide of the formula <FORM:1123954/C2/1> and treating the latter with R1R2NH, optionally followed in either case by partial hydrogenation of compounds in which R is R3C:C-, to give compounds in which R is R3CH:CH-, and/or salt formation. The preparation of starting materials of Formula (II) is described. The compounds of the invention are analgesics, and may be administered in the form of pharmaceutical preparations containing them together with a carrier.
GB21527/66A 1966-05-14 1966-05-14 Aryl carbinols Expired GB1123954A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB21527/66A GB1123954A (en) 1966-05-14 1966-05-14 Aryl carbinols
IL2791567A IL27915A (en) 1966-05-14 1967-05-04 Aminomethyl-phenyl-alkynyl (alkenyl)carbinol derivatives
FI131467A FI44229C (en) 1966-05-14 1967-05-08 Process for the preparation of analgesic beta-unsaturated-beta-hydroxy-beta-phenylethylamines and their acid addition salts
DE19671618154 DE1618154A1 (en) 1966-05-14 1967-05-09 Process for the preparation of aryl carbinols
NL6706503A NL6706503A (en) 1966-05-14 1967-05-09
NO16808367A NO116077B (en) 1966-05-14 1967-05-10
AT441767A AT273927B (en) 1966-05-14 1967-05-11 Process for the preparation of new 1-substituted 1-phenyl-2-aminoethanols and their acid addition salts
DK252567A DK121603B (en) 1966-05-14 1967-05-12 Analogous process for the preparation of arylcarbinols or acid addition salts thereof.
CH676367A CH475942A (en) 1966-05-14 1967-05-12 Process for the production of phenylcarbinols
FR106201A FR6469M (en) 1966-05-14 1967-05-12
BE698465D BE698465A (en) 1966-05-14 1967-05-12
ES340554A ES340554A1 (en) 1966-05-14 1967-05-13 Aryl carbinols

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB21527/66A GB1123954A (en) 1966-05-14 1966-05-14 Aryl carbinols

Publications (1)

Publication Number Publication Date
GB1123954A true GB1123954A (en) 1968-08-14

Family

ID=10164416

Family Applications (1)

Application Number Title Priority Date Filing Date
GB21527/66A Expired GB1123954A (en) 1966-05-14 1966-05-14 Aryl carbinols

Country Status (12)

Country Link
AT (1) AT273927B (en)
BE (1) BE698465A (en)
CH (1) CH475942A (en)
DE (1) DE1618154A1 (en)
DK (1) DK121603B (en)
ES (1) ES340554A1 (en)
FI (1) FI44229C (en)
FR (1) FR6469M (en)
GB (1) GB1123954A (en)
IL (1) IL27915A (en)
NL (1) NL6706503A (en)
NO (1) NO116077B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0097425A2 (en) * 1982-06-14 1984-01-04 Imperial Chemical Industries Plc Fungicidal or plant growth regulating triazolyl ethanols

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0097425A2 (en) * 1982-06-14 1984-01-04 Imperial Chemical Industries Plc Fungicidal or plant growth regulating triazolyl ethanols
EP0097425A3 (en) * 1982-06-14 1984-03-28 Imperial Chemical Industries Plc Fungicidal or plant growth regulating triazolyl ethanols

Also Published As

Publication number Publication date
DK121603B (en) 1971-11-08
CH475942A (en) 1969-07-31
NO116077B (en) 1969-01-27
FI44229C (en) 1971-10-11
DE1618154A1 (en) 1971-03-25
AT273927B (en) 1969-08-25
NL6706503A (en) 1967-11-15
FI44229B (en) 1971-06-30
FR6469M (en) 1968-11-18
IL27915A (en) 1971-01-28
ES340554A1 (en) 1968-06-01
BE698465A (en) 1967-11-13

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