GB1123415A - Berbine derivatives and processes for the preparation thereof - Google Patents
Berbine derivatives and processes for the preparation thereofInfo
- Publication number
- GB1123415A GB1123415A GB23490/67A GB2349067A GB1123415A GB 1123415 A GB1123415 A GB 1123415A GB 23490/67 A GB23490/67 A GB 23490/67A GB 2349067 A GB2349067 A GB 2349067A GB 1123415 A GB1123415 A GB 1123415A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dimethoxyphenethyl
- cyclization
- nitro
- processes
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel compounds of the general formula <FORM:1123415/C2/1> in which X and Z each represent a hydrogen atom and Y represents two hydrogen atoms, or X and Z together represent a double bond and Y represents an oxygen atom are obtained by (a) cyclization of an ester of 2-carboxy-4-nitro-N-b -(31, 41-dimethoxyphenethyl)-phenylacetamide III e.g. with phosphorus oxychloride, or (b) by cyclization of 2-hydroxymethyl-4-nitro-N-b -(31,41 - dimethoxyphenethyl) - phenyl acetamide VII and reduction of the olefinic bond so formed. Reduction may be effected by means of an alkali metal borohydride. The starting compound VII may be obtained by reducing the ester of the acid of Formula III with an alkali metal borohydride.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR994859A FR1514084A (en) | 1964-11-13 | 1964-11-13 | Berbine derivatives and methods of preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1123415A true GB1123415A (en) | 1968-08-14 |
Family
ID=8842445
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23489/67A Expired GB1123414A (en) | 1964-11-13 | 1965-11-12 | Substituted phenylacetamides and processes for the preparation thereof |
| GB23490/67A Expired GB1123415A (en) | 1964-11-13 | 1965-11-12 | Berbine derivatives and processes for the preparation thereof |
| GB48157/65A Expired GB1123413A (en) | 1964-11-13 | 1965-11-12 | Berbine derivatives and processes for the preparation thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23489/67A Expired GB1123414A (en) | 1964-11-13 | 1965-11-12 | Substituted phenylacetamides and processes for the preparation thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB48157/65A Expired GB1123413A (en) | 1964-11-13 | 1965-11-12 | Berbine derivatives and processes for the preparation thereof |
Country Status (8)
| Country | Link |
|---|---|
| BR (1) | BR6574829D0 (en) |
| CH (1) | CH467264A (en) |
| DE (2) | DE1620172B1 (en) |
| FR (3) | FR1514084A (en) |
| GB (3) | GB1123414A (en) |
| IL (2) | IL32770A (en) |
| NL (4) | NL6514686A (en) |
| SE (2) | SE321685B (en) |
-
0
- NL NL129872D patent/NL129872C/xx active
-
1964
- 1964-11-13 FR FR994859A patent/FR1514084A/en not_active Expired
-
1965
- 1965-02-11 FR FR5222A patent/FR4125M/fr not_active Expired
- 1965-02-12 FR FR5388A patent/FR4043M/fr not_active Expired
- 1965-10-19 SE SE13526/65A patent/SE321685B/xx unknown
- 1965-10-19 SE SE10213/67A patent/SE353538B/xx unknown
- 1965-11-04 IL IL32770A patent/IL32770A/en unknown
- 1965-11-04 IL IL24573A patent/IL24573A/en unknown
- 1965-11-10 CH CH1547565A patent/CH467264A/en unknown
- 1965-11-12 BR BR174829/65A patent/BR6574829D0/en unknown
- 1965-11-12 NL NL6514686A patent/NL6514686A/xx unknown
- 1965-11-12 GB GB23489/67A patent/GB1123414A/en not_active Expired
- 1965-11-12 DE DE1965R0041972 patent/DE1620172B1/en active Pending
- 1965-11-12 GB GB23490/67A patent/GB1123415A/en not_active Expired
- 1965-11-12 DE DE19651620194 patent/DE1620194A1/en active Pending
- 1965-11-12 GB GB48157/65A patent/GB1123413A/en not_active Expired
-
1969
- 1969-02-28 NL NL6903198A patent/NL6903198A/xx unknown
- 1969-02-28 NL NL6903199A patent/NL6903199A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL32770A (en) | 1970-03-22 |
| DE1620195A1 (en) | 1970-06-04 |
| FR1514084A (en) | 1968-02-23 |
| NL129872C (en) | |
| CH467264A (en) | 1969-01-15 |
| IL24573A (en) | 1969-11-30 |
| NL6903199A (en) | 1969-05-27 |
| SE321685B (en) | 1970-03-16 |
| DE1620194A1 (en) | 1970-06-04 |
| FR4125M (en) | 1966-04-25 |
| BR6574829D0 (en) | 1973-12-26 |
| DE1620192A1 (en) | 1970-06-04 |
| NL6514686A (en) | 1966-05-16 |
| GB1123413A (en) | 1968-08-14 |
| NL6903198A (en) | 1969-05-27 |
| GB1123414A (en) | 1968-08-14 |
| FR4043M (en) | 1966-03-28 |
| SE353538B (en) | 1973-02-05 |
| DE1620172B1 (en) | 1972-04-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES422001A1 (en) | Imidazo {8 5,1-f{9 -as-triazines | |
| ES446677A1 (en) | Propylene oxide reaction products, process for their manufacture and their use | |
| ES418924A1 (en) | 9,11,15-Trihydroxy prost-5-enoic acid analogues | |
| JPS543087A (en) | Preparation of cephalosporin compound | |
| ES418114A1 (en) | 5-Methylthio-pyrimidine vasodilators | |
| ES424017A1 (en) | Halogen-containing phosphoric acid esters | |
| ES448607A1 (en) | Z-ethyl-3,6,6-trimethyl-2-cyclohexene-1-carboxylic acid esters | |
| ES400452A1 (en) | Plant growth regulant compositions containing 2-haloethanesulphinic acid compounds | |
| GB1123415A (en) | Berbine derivatives and processes for the preparation thereof | |
| ES449068A1 (en) | Isoxazole derivatives | |
| ES405555A1 (en) | 7-Alkoxycarbonyl-4-hydroxymethyl-1-phthalazone compounds | |
| ES402670A1 (en) | P-chlorobenzamidoacetohydroxamic acid | |
| ES422327A1 (en) | 2-oxo-2h-pyrimido(2,1-a)isoquinoline | |
| ES431287A1 (en) | 7-Trichloroacetamido-3-desacetoxy-cephalosporanic acid esters | |
| ES423950A1 (en) | 6-Substituted 3-carbethoxyhydrazinopyridazine | |
| ES392819A1 (en) | M-(amino-s-triazolyl)benzene-sulfonamides and their production | |
| GB1123104A (en) | 3-oxime-steroids and method of preparation | |
| ES456325A1 (en) | Quinoline carboxalic acid esters | |
| ES471125A1 (en) | 1-Substituted aminoindolines, process for their production and pharmaceutical compositions containing them. | |
| FR2118117A1 (en) | ||
| JPS5273825A (en) | Preparation of organic phosphorous compounds | |
| ES439431A1 (en) | Thieno-pyridine derivatives, process for their preparation and their applications | |
| GB1082547A (en) | Process for producing nitrosocyclohexane dimer | |
| GB1094810A (en) | Unsaturated 4,5-seco-steroid compounds, and processes for their preparation | |
| ES390754A1 (en) | 3-substituted-6-alkyl-2,3,6,9-tetrahydro-2,9-dioxothiazolo(5,4-f)-quinoline-8-carboxylic acids and methods for producing same |