GB1117626A - Substituted xylenediols - Google Patents
Substituted xylenediolsInfo
- Publication number
- GB1117626A GB1117626A GB3801566A GB3801566A GB1117626A GB 1117626 A GB1117626 A GB 1117626A GB 3801566 A GB3801566 A GB 3801566A GB 3801566 A GB3801566 A GB 3801566A GB 1117626 A GB1117626 A GB 1117626A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lithium
- alkyl
- radicals
- compounds
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel amino - alkyl - xylenediols have the formula <FORM:1117626/C2/1> where R is a di-C1- 6-alkylamino-C1- 6-alkyl, amino - C1- 6 - alkyl, C1- 6 - alkylamino - C1- 6 alkyl radical or a group comprising a heterocyclic ring linked through a nitrogen to a C1- 6 alkyl group; both the R1 radicals are the same and represent H, alkyl, aryl, aralkyl or heterocyclic radicals. The benzene nucleus may contain one or more C1- 6 alkyl, C1- 6 alkoxy, CF3 or halo radicals. The novel compounds in which both R1 radicals are hydrogen are obtained by treating a compound of the formula <FORM:1117626/C2/2> with an alkali metal aluminohydride reducing agent, at ambient temperatures in the presence of an inert organic solvent, and recovering the aminoalkyl xylenediol. The compounds in which both R1 radicals are other than hydrogen are obtained by treating the above starting materials with R1MgBr or R1Li in an inert solvent at a temperature of from ambient temperature to the reflux temperature of the solvent. Organolithium compounds, e.g. p-tolyl-lithium, p - chlorophenyl - lithium, p - fluorophenyl lithium, and m-trifluoromethylphenyl lithium, are obtained by reacting n-butyl-lithium with the correspondingly substituted bromobenzene. o-Tolyl lithium is obtained by heating o-bromotoluene in ether with a lithium dispersion. Pharmaceutical compositions, useful as anti-cholinergic, antipyretic, anti-inflammatory and central nervous system stimulant agents, comprise one of the above aminoalkyl xylene-diols together with a pharmaceutical diluent or carrier in unit dosage form such as a tablet, suspension, solution or suppository.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3801566A GB1117626A (en) | 1966-08-24 | 1966-08-24 | Substituted xylenediols |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3801566A GB1117626A (en) | 1966-08-24 | 1966-08-24 | Substituted xylenediols |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1117626A true GB1117626A (en) | 1968-06-19 |
Family
ID=10400600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3801566A Expired GB1117626A (en) | 1966-08-24 | 1966-08-24 | Substituted xylenediols |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1117626A (en) |
-
1966
- 1966-08-24 GB GB3801566A patent/GB1117626A/en not_active Expired
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