GB1115604A - Dibenzocycloheptatriene derivatives and their preparation - Google Patents
Dibenzocycloheptatriene derivatives and their preparationInfo
- Publication number
- GB1115604A GB1115604A GB27275/66A GB2727566A GB1115604A GB 1115604 A GB1115604 A GB 1115604A GB 27275/66 A GB27275/66 A GB 27275/66A GB 2727566 A GB2727566 A GB 2727566A GB 1115604 A GB1115604 A GB 1115604A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- radical
- alkyl
- compounds
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QPJORFLSOJAUNL-UHFFFAOYSA-N dibenzo[a,d][7]annulene Chemical class C1=CC2=CC=CC=C2CC2=CC=CC=C21 QPJORFLSOJAUNL-UHFFFAOYSA-N 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 10
- 239000002253 acid Substances 0.000 abstract 6
- 125000005843 halogen group Chemical group 0.000 abstract 6
- -1 4-R-substituted-piperidino, morpholino Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004414 alkyl thio group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 150000002576 ketones Chemical class 0.000 abstract 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001298 alcohols Chemical class 0.000 abstract 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 3
- 150000002148 esters Chemical group 0.000 abstract 3
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical class OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 abstract 3
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 3
- FESDHLLVLYZNFY-UHFFFAOYSA-N 2-benzylbenzoic acid Chemical compound OC(=O)C1=CC=CC=C1CC1=CC=CC=C1 FESDHLLVLYZNFY-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000001805 chlorine compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001590 oxidative effect Effects 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 238000006680 Reformatsky reaction Methods 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000002111 antiemetic agent Substances 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 235000019445 benzyl alcohol Nutrition 0.000 abstract 1
- 150000001661 cadmium Chemical class 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 239000008016 pharmaceutical coating Substances 0.000 abstract 1
- 229960003424 phenylacetic acid Drugs 0.000 abstract 1
- 239000003279 phenylacetic acid Substances 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR21444A FR1469469A (fr) | 1965-06-18 | 1965-06-18 | Nouveaux dérivés du dibenzocycloheptatriène et leur préparation |
| FR60266A FR90399E (fr) | 1965-06-18 | 1966-05-04 | Nouveaux dérivés du dibenzocycloheptatriène et leur préparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1115604A true GB1115604A (en) | 1968-05-29 |
Family
ID=26164182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27275/66A Expired GB1115604A (en) | 1965-06-18 | 1966-06-17 | Dibenzocycloheptatriene derivatives and their preparation |
Country Status (14)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4188485A (en) * | 1978-06-16 | 1980-02-12 | G. D. Searle & Co. | 1-[(10,11-Dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)methyl]-4-substituted piperidines and related compounds |
| JPS5649337A (en) * | 1979-09-29 | 1981-05-02 | Toa Eiyou Kagaku Kogyo Kk | Dibenzo a,d cycloheptene derivative and its preparation |
| WO1996031500A1 (en) * | 1995-04-07 | 1996-10-10 | Novo Nordisk A/S | Novel heterocyclic compounds |
-
1965
- 1965-06-18 FR FR21444A patent/FR1469469A/fr not_active Expired
- 1965-08-17 FR FR28552A patent/FR4787M/fr not_active Expired
-
1966
- 1966-05-04 FR FR60266A patent/FR90399E/fr not_active Expired
- 1966-06-10 NL NL6608103A patent/NL6608103A/xx unknown
- 1966-06-14 BR BR180379/66A patent/BR6680379D0/pt unknown
- 1966-06-14 AT AT566666A patent/AT268234B/de active
- 1966-06-15 US US557604A patent/US3567730A/en not_active Expired - Lifetime
- 1966-06-16 IL IL25976A patent/IL25976A/xx unknown
- 1966-06-16 DE DE19661593314 patent/DE1593314A1/de active Pending
- 1966-06-17 LU LU51347A patent/LU51347A1/xx unknown
- 1966-06-17 CH CH881066A patent/CH457416A/fr unknown
- 1966-06-17 NO NO163504A patent/NO123280B/no unknown
- 1966-06-17 DK DK314866AA patent/DK129195B/da unknown
- 1966-06-17 BE BE682740D patent/BE682740A/xx unknown
- 1966-06-17 SE SE08331/66A patent/SE330690B/xx unknown
- 1966-06-17 GB GB27275/66A patent/GB1115604A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AT268234B (de) | 1969-02-10 |
| BR6680379D0 (pt) | 1973-12-26 |
| DK129195B (da) | 1974-09-09 |
| LU51347A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1966-08-17 |
| NL6608103A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1966-12-19 |
| US3567730A (en) | 1971-03-02 |
| DE1593314A1 (de) | 1971-01-28 |
| CH457416A (fr) | 1968-06-15 |
| NO123280B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-10-25 |
| DK129195C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-01-27 |
| BE682740A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1966-12-19 |
| FR1469469A (fr) | 1967-02-17 |
| IL25976A (en) | 1970-04-20 |
| FR4787M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1967-01-30 |
| SE330690B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1970-11-30 |
| FR90399E (fr) | 1967-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL930018I1 (nl) | (Piperidinylalkyl) chinazolinederivaten,werkwijze voor hun bereiding en farmaceutische preparaten die ze bevatten | |
| ES370394A1 (es) | Procedimiento para la preparacion de nuevas 5-11-dihidro-6h-pirido (2,3-b) (1,4) benzodiazepin-6-ona y sus sales. | |
| GB904208A (en) | New phenthiazine derivatives and processes for their preparation | |
| GEP19960641B (en) | Process for production of [3h]-imidazo[5,1-d]-1,2,3,5-tetrazin-4-one derivatives | |
| WO1998009953A3 (de) | Azinyloxy- und phenoxy-diaryl-carbonsäure derivate, deren herstellung und deren verwendung als gemischte eta/etb endothelin-rezeptorantagonist | |
| GB959994A (en) | Basically substituted compounds and a process for their production | |
| ES247857A1 (es) | Un método para la preparacion de derivados de pirrolopirimidina | |
| IE860283L (en) | Alkene, alkyne or cycloalkylene derivatives | |
| ES486824A1 (es) | Procedimiento para la preparacion de nuevos derivados de 4- (naftilmetil) piperidinas | |
| ES479820A1 (es) | Procedimiento para la preparacion de isoquinoleinas. | |
| IE782084L (en) | Quinolylguanidine derivatives | |
| GB1115604A (en) | Dibenzocycloheptatriene derivatives and their preparation | |
| GB1481813A (en) | Substituted thiazolinylidenyl ketones and their pharmaceutical compositions | |
| GB991589A (en) | Novel [1,2-ª‡]imidazopyridines and a process for the manufacture thereof | |
| ES353213A1 (es) | Procedimiento para la produccion de derivados de dibenzo- tiazepina. | |
| GB1158279A (en) | Carbocyclic Ferrocenes | |
| GB1460761A (en) | Dihalogenophenol derivatives | |
| IE790163L (en) | Thieno-pyridines | |
| HUT59112A (en) | Process for producing triazolylcarboxylic acid thioamide derivatives and pharmaceutical compositions comprising same | |
| IE33462L (en) | Benzodioxole compounds | |
| ES8301933A1 (es) | "procedimiento para la preparacion de derivados de 4-(5)-alcohil-mercaptoimidazoles". | |
| GB1157246A (en) | Dibenzothiepin Derivatives and their preparation | |
| GB1116608A (en) | New dibenzocycloheptadiene derivatives | |
| HUP0100407A2 (hu) | Eljárás kinolin-karbamoil- és kinolin-tiokarbamoil-származékok előállítására és az eljárás intermedierjei | |
| ES392288A1 (es) | Procedimiento para la preparacion de derivados de nitrofu- rilamidina. |