GB1114030A - 2-dimethylphenyl-benzofurans and compositions containing them - Google Patents

2-dimethylphenyl-benzofurans and compositions containing them

Info

Publication number
GB1114030A
GB1114030A GB20574/67A GB2057467A GB1114030A GB 1114030 A GB1114030 A GB 1114030A GB 20574/67 A GB20574/67 A GB 20574/67A GB 2057467 A GB2057467 A GB 2057467A GB 1114030 A GB1114030 A GB 1114030A
Authority
GB
United Kingdom
Prior art keywords
benzofuran
dimethylphenyl
acid
general formula
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20574/67A
Inventor
Rainer Klink
Karl-Heinz Baron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck KGaA
Original Assignee
E Merck AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E Merck AG filed Critical E Merck AG
Publication of GB1114030A publication Critical patent/GB1114030A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a process for the preparation of a 2-dimethyl phenyl benzofuran of the general formula <FORM:1114030/C2/1> by (1) heating a ketone of a general formula <FORM:1114030/C2/2> with an acid catalyst to effect rearrangement, e.g. polyphosphoric acid or (2) decarboxylating and dehydrating an acid of the general formula <FORM:1114030/C2/3> in which R1, R2 and R3 are hydrogen or one of them is a methyl group. Compounds claimed per se are 2-(2,4-dimethylphenyl)-benzofuran, 2 - (2,4 - dimethylphenyl) - 5 - methyl - benzofuran, 2 - (2,4 - dimethylphenyl) - 6 - methyl-benzofuran, 2 - (2,4 - dimethylphenyl) - 7 - methyl-benzofuran.ALSO:A cosmetic composition capable of absorbing ultra-violet radiation comprises one or more compounds of a general formula: <FORM:1114030/A5-A6/1> in which R1, R2 and R3 are hydrogen or one of them is a methyl group in association with a cosmetic carrier. Many carriers are specified. The compositions may also contain one or more other UV radiation absorbers, such as the sodium salt of 2 - phenylbenzimidazole - 5 - sulphonic acid, the sodium salt of 3,4 - dimethylphenylglyoxylic acid, 4 - phenylbenzophenone or 4 - phenyl - benzophenone - 2\sv - carboxylic acid isooctyl ester. Other additives, such as perfumes, preserving agents or physiologically acceptable dyes, may also be added. Examples are given of compositions in the form of oils, creams, milk, aerosol and lipsticks.
GB20574/67A 1966-05-20 1967-05-03 2-dimethylphenyl-benzofurans and compositions containing them Expired GB1114030A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEM0069570 1966-05-20

Publications (1)

Publication Number Publication Date
GB1114030A true GB1114030A (en) 1968-05-15

Family

ID=7313078

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20574/67A Expired GB1114030A (en) 1966-05-20 1967-05-03 2-dimethylphenyl-benzofurans and compositions containing them

Country Status (9)

Country Link
US (1) US3499914A (en)
BE (1) BE698629A (en)
CH (1) CH480074A (en)
DE (1) DE1642090A1 (en)
ES (1) ES340745A1 (en)
FR (1) FR1548293A (en)
GB (1) GB1114030A (en)
NL (1) NL6706409A (en)
SE (1) SE320387B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098882A (en) * 1974-09-26 1978-07-04 L'oreal Anti-solar composition

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787575A (en) * 1971-08-13 1973-02-14 Hoechst Ag BENZOFURANNE DERIVATIVES FOR USE AS OPTICAL BLASTERS
GB2097810B (en) * 1981-04-04 1984-11-28 Sevendart Ltd Apparatus for use in sunbathing
LU85544A1 (en) * 1984-09-19 1986-04-03 Cird AROMATIC HETEROCYCLIC DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THE THERAPEUTIC AND COSMETIC FIELDS
US4665112A (en) * 1986-01-02 1987-05-12 General Electric Company Ultraviolet radiation stabilized polyphenylene ether resins
US6764693B1 (en) 1992-12-11 2004-07-20 Amaox, Ltd. Free radical quenching composition and a method to increase intracellular and/or extracellular antioxidants
US5362481A (en) * 1993-03-05 1994-11-08 3V Inc. Benzofuran derivatives and the use thereof as stabilizers against UV radiations
US5468470A (en) * 1993-08-06 1995-11-21 3V Inc. Benzofuran derivatives and the use thereof as stabilizers against UV radiations
IT1278535B1 (en) * 1995-12-14 1997-11-24 3V Sigma Spa BENZOPHURAN DERIVATIVES AND THEIR USE AS PHOTOSTABILIZERS AND SUN FILTERS
CN104237150B (en) * 2014-10-13 2016-08-24 深圳市星源材质科技股份有限公司 The detection method of paraffin oil concentration in organic solvent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE676103C (en) * 1933-03-31 1939-05-25 I G Farbenindustrie Akt Ges Radiation protection agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098882A (en) * 1974-09-26 1978-07-04 L'oreal Anti-solar composition

Also Published As

Publication number Publication date
SE320387B (en) 1970-02-09
FR1548293A (en) 1968-12-06
BE698629A (en) 1967-11-20
ES340745A1 (en) 1968-09-16
CH480074A (en) 1969-10-31
DE1642090A1 (en) 1971-05-19
NL6706409A (en) 1967-11-21
US3499914A (en) 1970-03-10

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