GB1113829A - Pseudopederin derivative - Google Patents
Pseudopederin derivativeInfo
- Publication number
- GB1113829A GB1113829A GB2513866A GB2513866A GB1113829A GB 1113829 A GB1113829 A GB 1113829A GB 2513866 A GB2513866 A GB 2513866A GB 2513866 A GB2513866 A GB 2513866A GB 1113829 A GB1113829 A GB 1113829A
- Authority
- GB
- United Kingdom
- Prior art keywords
- palladium
- catalyst
- dihydrodesoxypseudopederin
- pseudopederin
- hydrogenation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NNNVJFAPLNIYPF-FQZCGRDXSA-N (2s)-n-[(s)-[(2s,4r,6r)-6-[(2s)-2,3-dimethoxypropyl]-4-hydroxy-5,5-dimethyloxan-2-yl]-methoxymethyl]-2-hydroxy-2-[(2r,5r,6r)-2-hydroxy-5,6-dimethyl-4-methylideneoxan-2-yl]acetamide Chemical class C1[C@@H](O)C(C)(C)[C@@H](C[C@@H](COC)OC)O[C@@H]1[C@H](OC)NC(=O)[C@@H](O)[C@]1(O)O[C@H](C)[C@H](C)C(=C)C1 NNNVJFAPLNIYPF-FQZCGRDXSA-N 0.000 title abstract 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 6
- 239000003054 catalyst Substances 0.000 abstract 4
- 238000005984 hydrogenation reaction Methods 0.000 abstract 4
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical class C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- MHRARRIFWSILEQ-UHFFFAOYSA-N Pederin Natural products COCC(CC1OC2C(NC(=O)C(O)C3(CC(=O)C(C)C(C)O3)OC)OCOC2C(OC)C1(C)C)OC MHRARRIFWSILEQ-UHFFFAOYSA-N 0.000 abstract 2
- RHUVSEWLTVNPLK-UHFFFAOYSA-N Pseudopederin Natural products COCC(CC1OC(C(NC(=O)C(O)C2(O)CC(=C)C(C)C(C)O2)OC)C(O)CC1(C)C)OC RHUVSEWLTVNPLK-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 229910052763 palladium Inorganic materials 0.000 abstract 2
- ZNEZZONMADKYTB-VRCUBXEUSA-N pederin Chemical compound C1[C@@H](O)C(C)(C)[C@@H](C[C@@H](COC)OC)O[C@@H]1[C@H](OC)NC(=O)[C@@H](O)[C@]1(OC)O[C@H](C)[C@H](C)C(=C)C1 ZNEZZONMADKYTB-VRCUBXEUSA-N 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 230000002927 anti-mitotic effect Effects 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1318365 | 1965-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1113829A true GB1113829A (en) | 1968-05-15 |
Family
ID=11144288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2513866A Expired GB1113829A (en) | 1965-06-11 | 1966-06-06 | Pseudopederin derivative |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR188E (enExample) |
| GB (1) | GB1113829A (enExample) |
-
0
- FR FR188D patent/FR188E/fr active Active
-
1966
- 1966-06-06 GB GB2513866A patent/GB1113829A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR188E (enExample) |
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